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Neural correlates of working memory performance in adolescents and young adults with dyslexia.
Neuropsychologia. 2008 Jan 31; 46(2):640-8.N

Abstract

Behavioral studies indicate deficits in phonological working memory (WM) and executive functioning in dyslexics. However, little is known about the underlying functional neuroanatomy. In the present study, neural correlates of WM in adolescents and young adults with dyslexia were investigated using event-related functional magnetic resonance imaging (fMRI) and a parametric verbal WM task which required the manipulation of verbal material. Dyslexics were not significantly slower than controls; however, they were less accurate with the highest WM demand. The functional analysis excluded incorrectly performed and omitted trials, thus controlling for potential activation confounds. Compared with control subjects, both increased and decreased activation of the prefrontal cortex were found in the dyslexic group. Dyslexics showed significantly more activation than controls with increasing WM demand in the left superior frontal gyrus (BA 8), as well as in the inferior frontal gyrus including Broca's area (BA 44) and its right homologue. Less activation was found in the middle frontal gyrus (BA 6) and in the superior parietal cortex (BA 7). A positive correlation between activation of prefrontal regions and verbal WM performance (as measured by digit span backwards) was found only in the dyslexic group. Accuracy deficits at the highest cognitive demand during the verbal WM task and the digit span backwards suggest that manipulation rather than maintenance is selectively impaired in dyslexics. The fMRI data provide further evidence for functional differences in cortical regions associated with language processing and executive function in subjects with dyslexia.

Authors+Show Affiliations

Department of Psychiatry, University of Ulm, Leimgrubenweg 12-14, 89075 Ulm, Germany. nenad.vasic@uni-ulm.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17950764

Citation

Vasic, Nenad, et al. "Neural Correlates of Working Memory Performance in Adolescents and Young Adults With Dyslexia." Neuropsychologia, vol. 46, no. 2, 2008, pp. 640-8.
Vasic N, Lohr C, Steinbrink C, et al. Neural correlates of working memory performance in adolescents and young adults with dyslexia. Neuropsychologia. 2008;46(2):640-8.
Vasic, N., Lohr, C., Steinbrink, C., Martin, C., & Wolf, R. C. (2008). Neural correlates of working memory performance in adolescents and young adults with dyslexia. Neuropsychologia, 46(2), 640-8.
Vasic N, et al. Neural Correlates of Working Memory Performance in Adolescents and Young Adults With Dyslexia. Neuropsychologia. 2008 Jan 31;46(2):640-8. PubMed PMID: 17950764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neural correlates of working memory performance in adolescents and young adults with dyslexia. AU - Vasic,Nenad, AU - Lohr,Christina, AU - Steinbrink,Claudia, AU - Martin,Claudia, AU - Wolf,Robert Christian, Y1 - 2007/09/12/ PY - 2007/02/28/received PY - 2007/09/04/revised PY - 2007/09/06/accepted PY - 2007/10/24/pubmed PY - 2008/5/3/medline PY - 2007/10/24/entrez SP - 640 EP - 8 JF - Neuropsychologia JO - Neuropsychologia VL - 46 IS - 2 N2 - Behavioral studies indicate deficits in phonological working memory (WM) and executive functioning in dyslexics. However, little is known about the underlying functional neuroanatomy. In the present study, neural correlates of WM in adolescents and young adults with dyslexia were investigated using event-related functional magnetic resonance imaging (fMRI) and a parametric verbal WM task which required the manipulation of verbal material. Dyslexics were not significantly slower than controls; however, they were less accurate with the highest WM demand. The functional analysis excluded incorrectly performed and omitted trials, thus controlling for potential activation confounds. Compared with control subjects, both increased and decreased activation of the prefrontal cortex were found in the dyslexic group. Dyslexics showed significantly more activation than controls with increasing WM demand in the left superior frontal gyrus (BA 8), as well as in the inferior frontal gyrus including Broca's area (BA 44) and its right homologue. Less activation was found in the middle frontal gyrus (BA 6) and in the superior parietal cortex (BA 7). A positive correlation between activation of prefrontal regions and verbal WM performance (as measured by digit span backwards) was found only in the dyslexic group. Accuracy deficits at the highest cognitive demand during the verbal WM task and the digit span backwards suggest that manipulation rather than maintenance is selectively impaired in dyslexics. The fMRI data provide further evidence for functional differences in cortical regions associated with language processing and executive function in subjects with dyslexia. SN - 0028-3932 UR - https://www.unboundmedicine.com/medline/citation/17950764/Neural_correlates_of_working_memory_performance_in_adolescents_and_young_adults_with_dyslexia_ DB - PRIME DP - Unbound Medicine ER -