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Usefulness of fasting blood glucose to predict vascular outcomes among individuals without diabetes mellitus (from the Northern Manhattan Study).
Am J Cardiol 2007; 100(9):1404-9AJ

Abstract

It is still controversial whether fasting blood glucose (FBG) is associated with the risk of vascular outcomes among nondiabetic subjects. We sought to determine whether FBG is associated with vascular outcomes and whether this association differs among various racial or ethnic groups. In the Northern Manhattan Study, a total of 2,372 subjects (mean age 68.8 +/- 10.7 years, 36% men) without a history of diabetes mellitus, stroke, or myocardial infarction (MI) were followed for an average of 7.5 years for ischemic stroke, MI, and combined vascular events defined as either ischemic stroke, MI, or vascular death. Cox proportional-hazards models were used to calculate hazard ratios and 95% confidence intervals (CIs) of FBG-associated risk for vascular outcomes after adjusting for age, gender, race/ethnicity, education, body mass index, hypertension, current smoking, previous coronary artery disease, low-density lipoprotein cholesterol, alcohol intake, and physical activity. The incidences of MI, ischemic stroke, and combined vascular events were 5.5, 6.3, and 20.0 per 1,000 person-years, respectively. Each SD increase of FBG (27 mg/dl) was associated with statistically significantly increased risks of combined vascular events (hazard ratio 1.20, 95% CI 1.09 to 1.31) and MI (hazard ratio 1.21, 95% CI 1.02 to 1.44), but the effect was weaker, evident for ischemic stroke (hazard ratio 1.13, 95% CI 0.95 to 1.34). FBG was significantly associated with incident ischemic stroke among African-American subjects (hazard ratio 1.38, 95% CI 1.09 to 1.74) and incident MI among Hispanic subjects (hazard ratio 1.24, 95% CI 0.99 to 1.55). In conclusion, FBG was an independent predictor for vascular outcomes among individuals without history of diabetes from this multiethnic cohort. The effects were more apparent for MI than for ischemic stroke; however, FBG was a strong predictor of ischemic stroke among African-American subjects.

Authors+Show Affiliations

Center for Behavioral Cardiovascular Health, Division of General Medicine, Columbia University Medical Center, New York, NY, USA. kellz@jichi.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17950798

Citation

Eguchi, Kazuo, et al. "Usefulness of Fasting Blood Glucose to Predict Vascular Outcomes Among Individuals Without Diabetes Mellitus (from the Northern Manhattan Study)." The American Journal of Cardiology, vol. 100, no. 9, 2007, pp. 1404-9.
Eguchi K, Boden-Albala B, Jin Z, et al. Usefulness of fasting blood glucose to predict vascular outcomes among individuals without diabetes mellitus (from the Northern Manhattan Study). Am J Cardiol. 2007;100(9):1404-9.
Eguchi, K., Boden-Albala, B., Jin, Z., Di Tullio, M. R., Rundek, T., Rodriguez, C. J., ... Sacco, R. L. (2007). Usefulness of fasting blood glucose to predict vascular outcomes among individuals without diabetes mellitus (from the Northern Manhattan Study). The American Journal of Cardiology, 100(9), pp. 1404-9.
Eguchi K, et al. Usefulness of Fasting Blood Glucose to Predict Vascular Outcomes Among Individuals Without Diabetes Mellitus (from the Northern Manhattan Study). Am J Cardiol. 2007 Nov 1;100(9):1404-9. PubMed PMID: 17950798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of fasting blood glucose to predict vascular outcomes among individuals without diabetes mellitus (from the Northern Manhattan Study). AU - Eguchi,Kazuo, AU - Boden-Albala,Bernadette, AU - Jin,Zhezhen, AU - Di Tullio,Marco R, AU - Rundek,Tatjana, AU - Rodriguez,Carlos J, AU - Homma,Shunichi, AU - Sacco,Ralph L, Y1 - 2007/08/17/ PY - 2007/04/11/received PY - 2007/06/05/revised PY - 2007/06/05/accepted PY - 2007/10/24/pubmed PY - 2007/12/21/medline PY - 2007/10/24/entrez SP - 1404 EP - 9 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 100 IS - 9 N2 - It is still controversial whether fasting blood glucose (FBG) is associated with the risk of vascular outcomes among nondiabetic subjects. We sought to determine whether FBG is associated with vascular outcomes and whether this association differs among various racial or ethnic groups. In the Northern Manhattan Study, a total of 2,372 subjects (mean age 68.8 +/- 10.7 years, 36% men) without a history of diabetes mellitus, stroke, or myocardial infarction (MI) were followed for an average of 7.5 years for ischemic stroke, MI, and combined vascular events defined as either ischemic stroke, MI, or vascular death. Cox proportional-hazards models were used to calculate hazard ratios and 95% confidence intervals (CIs) of FBG-associated risk for vascular outcomes after adjusting for age, gender, race/ethnicity, education, body mass index, hypertension, current smoking, previous coronary artery disease, low-density lipoprotein cholesterol, alcohol intake, and physical activity. The incidences of MI, ischemic stroke, and combined vascular events were 5.5, 6.3, and 20.0 per 1,000 person-years, respectively. Each SD increase of FBG (27 mg/dl) was associated with statistically significantly increased risks of combined vascular events (hazard ratio 1.20, 95% CI 1.09 to 1.31) and MI (hazard ratio 1.21, 95% CI 1.02 to 1.44), but the effect was weaker, evident for ischemic stroke (hazard ratio 1.13, 95% CI 0.95 to 1.34). FBG was significantly associated with incident ischemic stroke among African-American subjects (hazard ratio 1.38, 95% CI 1.09 to 1.74) and incident MI among Hispanic subjects (hazard ratio 1.24, 95% CI 0.99 to 1.55). In conclusion, FBG was an independent predictor for vascular outcomes among individuals without history of diabetes from this multiethnic cohort. The effects were more apparent for MI than for ischemic stroke; however, FBG was a strong predictor of ischemic stroke among African-American subjects. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/17950798/Usefulness_of_fasting_blood_glucose_to_predict_vascular_outcomes_among_individuals_without_diabetes_mellitus__from_the_Northern_Manhattan_Study__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(07)01459-2 DB - PRIME DP - Unbound Medicine ER -