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The endocannabinoid system in the processing of anxiety and fear and how CB1 receptors may modulate fear extinction.
Pharmacol Res. 2007 Nov; 56(5):367-81.PR

Abstract

The endocannabinoid system recently emerged as an important modulator of many neuronal functions. Among them, the control of anxiety and acquired fear represents nowadays one of the most interesting fields of research. Despite contrasting results obtained by the use of cannabinoid receptor agonists in experimental animals, there is growing evidence that the physiological activation of the endocannabinoid system plays a central role in the control of basal anxiety levels and in the modulation of fear responses. This review will summarise recent data on the role of the endocannabinoid system in most commonly used tests of anxiety and in the processing of acquired fear, with particular attention to its involvement in fear extinction. Finally, a neurobiological model possibly able to implement the role of the endocannabinoid system in these processes will be proposed.

Authors+Show Affiliations

Research Centre INSERM U862, AVENIR Team Molecular Mechanisms of Behavioural Adaptation, 146 rue Léo Saignat, 33700 Bordeaux, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17951068

Citation

Lafenêtre, Pauline, et al. "The Endocannabinoid System in the Processing of Anxiety and Fear and How CB1 Receptors May Modulate Fear Extinction." Pharmacological Research, vol. 56, no. 5, 2007, pp. 367-81.
Lafenêtre P, Chaouloff F, Marsicano G. The endocannabinoid system in the processing of anxiety and fear and how CB1 receptors may modulate fear extinction. Pharmacol Res. 2007;56(5):367-81.
Lafenêtre, P., Chaouloff, F., & Marsicano, G. (2007). The endocannabinoid system in the processing of anxiety and fear and how CB1 receptors may modulate fear extinction. Pharmacological Research, 56(5), 367-81.
Lafenêtre P, Chaouloff F, Marsicano G. The Endocannabinoid System in the Processing of Anxiety and Fear and How CB1 Receptors May Modulate Fear Extinction. Pharmacol Res. 2007;56(5):367-81. PubMed PMID: 17951068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The endocannabinoid system in the processing of anxiety and fear and how CB1 receptors may modulate fear extinction. AU - Lafenêtre,Pauline, AU - Chaouloff,Francis, AU - Marsicano,Giovanni, Y1 - 2007/09/08/ PY - 2007/06/18/received PY - 2007/08/13/revised PY - 2007/09/05/accepted PY - 2007/10/24/pubmed PY - 2008/4/9/medline PY - 2007/10/24/entrez SP - 367 EP - 81 JF - Pharmacological research JO - Pharmacol. Res. VL - 56 IS - 5 N2 - The endocannabinoid system recently emerged as an important modulator of many neuronal functions. Among them, the control of anxiety and acquired fear represents nowadays one of the most interesting fields of research. Despite contrasting results obtained by the use of cannabinoid receptor agonists in experimental animals, there is growing evidence that the physiological activation of the endocannabinoid system plays a central role in the control of basal anxiety levels and in the modulation of fear responses. This review will summarise recent data on the role of the endocannabinoid system in most commonly used tests of anxiety and in the processing of acquired fear, with particular attention to its involvement in fear extinction. Finally, a neurobiological model possibly able to implement the role of the endocannabinoid system in these processes will be proposed. SN - 1043-6618 UR - https://www.unboundmedicine.com/medline/citation/17951068/The_endocannabinoid_system_in_the_processing_of_anxiety_and_fear_and_how_CB1_receptors_may_modulate_fear_extinction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(07)00165-X DB - PRIME DP - Unbound Medicine ER -