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Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17.
Pulm Pharmacol Ther. 2008; 21(2):356-9.PP

Abstract

We examined the sensitivity of the cough reflex to inhaled citric acid in guinea pigs that had been actively sensitized with the protein fraction of Aspergillus restrictus strain A-17. The number of coughs elicited by an aerosol of 5% citric acid was significantly increased in the sensitized group compared to the non-sensitized group. The number of citric-acid-induced coughs in sensitized guinea pigs was dose-dependently and significantly reduced to the level in non-sensitized guinea pigs when animals were pretreated with fexofenadine, a selective histamine H1 receptor antagonist, 60min before citric acid inhalation. The bronchial responsiveness to inhaled methacholine or histamine in the sensitized group was not significantly heightened compared to the non-sensitized group. These results suggest that active sensitization with the protein fraction of A. restrictus by itself, that is without subsequent allergen challenge, enhances the excitability of cough receptors to tussive stimuli, and the physiologic features of this animal model are consistent with those of atopic cough.

Authors+Show Affiliations

Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo 142-8501, Japan. kamei@hoshi.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17951087

Citation

Kamei, Junzo, et al. "Atopic Cough-like Cough Hypersensitivity Caused By Active Sensitization With Protein Fraction of Aspergillus Restrictus Strain A-17." Pulmonary Pharmacology & Therapeutics, vol. 21, no. 2, 2008, pp. 356-9.
Kamei J, Takahashi Y, Itabashi T, et al. Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17. Pulm Pharmacol Ther. 2008;21(2):356-9.
Kamei, J., Takahashi, Y., Itabashi, T., Hayashi, S., & Kawai, K. (2008). Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17. Pulmonary Pharmacology & Therapeutics, 21(2), 356-9.
Kamei J, et al. Atopic Cough-like Cough Hypersensitivity Caused By Active Sensitization With Protein Fraction of Aspergillus Restrictus Strain A-17. Pulm Pharmacol Ther. 2008;21(2):356-9. PubMed PMID: 17951087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17. AU - Kamei,Junzo, AU - Takahashi,Yoshiki, AU - Itabashi,Takeshi, AU - Hayashi,Shunsuke, AU - Kawai,Ken-ichi, Y1 - 2007/09/21/ PY - 2007/06/13/received PY - 2007/08/28/revised PY - 2007/09/14/accepted PY - 2007/10/24/pubmed PY - 2008/8/2/medline PY - 2007/10/24/entrez SP - 356 EP - 9 JF - Pulmonary pharmacology & therapeutics JO - Pulm Pharmacol Ther VL - 21 IS - 2 N2 - We examined the sensitivity of the cough reflex to inhaled citric acid in guinea pigs that had been actively sensitized with the protein fraction of Aspergillus restrictus strain A-17. The number of coughs elicited by an aerosol of 5% citric acid was significantly increased in the sensitized group compared to the non-sensitized group. The number of citric-acid-induced coughs in sensitized guinea pigs was dose-dependently and significantly reduced to the level in non-sensitized guinea pigs when animals were pretreated with fexofenadine, a selective histamine H1 receptor antagonist, 60min before citric acid inhalation. The bronchial responsiveness to inhaled methacholine or histamine in the sensitized group was not significantly heightened compared to the non-sensitized group. These results suggest that active sensitization with the protein fraction of A. restrictus by itself, that is without subsequent allergen challenge, enhances the excitability of cough receptors to tussive stimuli, and the physiologic features of this animal model are consistent with those of atopic cough. SN - 1094-5539 UR - https://www.unboundmedicine.com/medline/citation/17951087/Atopic_cough_like_cough_hypersensitivity_caused_by_active_sensitization_with_protein_fraction_of_Aspergillus_restrictus_strain_A_17_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1094-5539(07)00090-9 DB - PRIME DP - Unbound Medicine ER -