Tags

Type your tag names separated by a space and hit enter

Hypersensitivity to aeroallergens in adult patients with atopic dermatitis develops due to the different immunological mechanisms.
Eur J Dermatol. 2007 Nov-Dec; 17(6):520-4.EJ

Abstract

Atopic dermatitis (AD) is a disease with a complex pathomechanism, it is very difficult to establish the exact factors which can either trigger or exacerbate the disease. Knowledge of the mechanisms involved in AD development can be increased by, among others, applying new diagnostic tests and careful assessment of the results obtained. The aim of this study was to determine the allergic mechanisms of hypersensitivity to selected aeroallergens in patients with AD. The study comprised 109 AD patients. In all the patients the total IgE level was measured and atopy patch tests and skin prick tests were performed. We also assessed the presence of specific IgE against house dust mite, birch-tree, mixed grass pollen and cat dander. The highest incidence of positive results was found for house dust mite allergens, irrespective of the test employed. Analysing hypersensitivity to all the examined allergens we revealed the presence of allergic mechanisms in 85.3% of the patients. In 30.2% of the examined individuals we proved a type I immunological response, in 45.9% -- both types I and IV in 9.2% -- only type IV in one patient. In 14.7% of the patients the results of all the tests performed were negative. Analysing hypersensitivity to particular aeroallergens, negative test results to house dust mite were observed in 25.8% of the patients. The percentage of positive results for birch pollen, grass pollen and cat dander were 45.0, 44.1 and 53.2, respectively. Analysis of the results showed that allergic reactions to the same aeroallergens may develop via different mechanisms. We also revealed that the coexistence of various mechanisms involved in the development of hypersensitivity to a particular aeroallergen may occur in individual patients.

Authors+Show Affiliations

Department of Dermatology, Central Clinical Hospital of Military Institute of Medicine, ul Szaserów 128, 00-909, Warsaw, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17951133

Citation

Samochocki, Zbigniew, et al. "Hypersensitivity to Aeroallergens in Adult Patients With Atopic Dermatitis Develops Due to the Different Immunological Mechanisms." European Journal of Dermatology : EJD, vol. 17, no. 6, 2007, pp. 520-4.
Samochocki Z, Owczarek W, Rujna P, et al. Hypersensitivity to aeroallergens in adult patients with atopic dermatitis develops due to the different immunological mechanisms. Eur J Dermatol. 2007;17(6):520-4.
Samochocki, Z., Owczarek, W., Rujna, P., & Raczka, A. (2007). Hypersensitivity to aeroallergens in adult patients with atopic dermatitis develops due to the different immunological mechanisms. European Journal of Dermatology : EJD, 17(6), 520-4.
Samochocki Z, et al. Hypersensitivity to Aeroallergens in Adult Patients With Atopic Dermatitis Develops Due to the Different Immunological Mechanisms. Eur J Dermatol. 2007 Nov-Dec;17(6):520-4. PubMed PMID: 17951133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypersensitivity to aeroallergens in adult patients with atopic dermatitis develops due to the different immunological mechanisms. AU - Samochocki,Zbigniew, AU - Owczarek,Witold, AU - Rujna,Paweł, AU - Raczka,Alicja, Y1 - 2007/10/19/ PY - 2007/07/04/accepted PY - 2007/10/24/pubmed PY - 2008/2/15/medline PY - 2007/10/24/entrez SP - 520 EP - 4 JF - European journal of dermatology : EJD JO - Eur J Dermatol VL - 17 IS - 6 N2 - Atopic dermatitis (AD) is a disease with a complex pathomechanism, it is very difficult to establish the exact factors which can either trigger or exacerbate the disease. Knowledge of the mechanisms involved in AD development can be increased by, among others, applying new diagnostic tests and careful assessment of the results obtained. The aim of this study was to determine the allergic mechanisms of hypersensitivity to selected aeroallergens in patients with AD. The study comprised 109 AD patients. In all the patients the total IgE level was measured and atopy patch tests and skin prick tests were performed. We also assessed the presence of specific IgE against house dust mite, birch-tree, mixed grass pollen and cat dander. The highest incidence of positive results was found for house dust mite allergens, irrespective of the test employed. Analysing hypersensitivity to all the examined allergens we revealed the presence of allergic mechanisms in 85.3% of the patients. In 30.2% of the examined individuals we proved a type I immunological response, in 45.9% -- both types I and IV in 9.2% -- only type IV in one patient. In 14.7% of the patients the results of all the tests performed were negative. Analysing hypersensitivity to particular aeroallergens, negative test results to house dust mite were observed in 25.8% of the patients. The percentage of positive results for birch pollen, grass pollen and cat dander were 45.0, 44.1 and 53.2, respectively. Analysis of the results showed that allergic reactions to the same aeroallergens may develop via different mechanisms. We also revealed that the coexistence of various mechanisms involved in the development of hypersensitivity to a particular aeroallergen may occur in individual patients. SN - 1167-1122 UR - https://www.unboundmedicine.com/medline/citation/17951133/Hypersensitivity_to_aeroallergens_in_adult_patients_with_atopic_dermatitis_develops_due_to_the_different_immunological_mechanisms_ DB - PRIME DP - Unbound Medicine ER -