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The effect of low dose omega-3 on plasma lipids in hemodialysis patients.
Saudi J Kidney Dis Transpl. 2007 Nov; 18(4):571-6.SJ

Abstract

Hemodialysis (HD) patients have a high incidence of cardiovascular disease and increased premature mortality. N-3 polyunsaturated fatty acids (PUFAs) are known to decrease plasma triglyceride (TG) levels and have a cardio-protective effect in subjects with normal renal function. The aim of this study was to investigate the effect of Omega-3 on plasma lipid levels in patients on HD. We included 33 patients on HD with serum TG higher than 200 mg/dl and total cholesterol higher than 220 mg/dl, in the study and randomly assigned them to treatment with 2 gm pearls of Omega-3 per day, given in two equal doses or a control group who did not receive this drug. The study was conducted for a period of 12 weeks. Patients were evaluated by measurement of fasting plasma lipid levels before and after the use of Omega-3. There was a significant (28%) increase in high-density lipoprotein levels (P %) decrease in serum TG levels (P < 0.02) in the group that received Omega-3 supplement. There were no changes in total cholesterol or low-density lipoprotein levels in either group. Our study suggests that supplementation with low-dose Omega-3 has a favorable effect on plasma lipid levels in patients on HD.

Authors+Show Affiliations

Mazandaran University of Medical Science, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17951945

Citation

Taziki, O, et al. "The Effect of Low Dose Omega-3 On Plasma Lipids in Hemodialysis Patients." Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol. 18, no. 4, 2007, pp. 571-6.
Taziki O, Lessan-Pezeshki M, Akha O, et al. The effect of low dose omega-3 on plasma lipids in hemodialysis patients. Saudi J Kidney Dis Transpl. 2007;18(4):571-6.
Taziki, O., Lessan-Pezeshki, M., Akha, O., & Vasheghani, F. (2007). The effect of low dose omega-3 on plasma lipids in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 18(4), 571-6.
Taziki O, et al. The Effect of Low Dose Omega-3 On Plasma Lipids in Hemodialysis Patients. Saudi J Kidney Dis Transpl. 2007;18(4):571-6. PubMed PMID: 17951945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of low dose omega-3 on plasma lipids in hemodialysis patients. AU - Taziki,O, AU - Lessan-Pezeshki,M, AU - Akha,O, AU - Vasheghani,F, PY - 2007/10/24/pubmed PY - 2008/4/16/medline PY - 2007/10/24/entrez SP - 571 EP - 6 JF - Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia JO - Saudi J Kidney Dis Transpl VL - 18 IS - 4 N2 - Hemodialysis (HD) patients have a high incidence of cardiovascular disease and increased premature mortality. N-3 polyunsaturated fatty acids (PUFAs) are known to decrease plasma triglyceride (TG) levels and have a cardio-protective effect in subjects with normal renal function. The aim of this study was to investigate the effect of Omega-3 on plasma lipid levels in patients on HD. We included 33 patients on HD with serum TG higher than 200 mg/dl and total cholesterol higher than 220 mg/dl, in the study and randomly assigned them to treatment with 2 gm pearls of Omega-3 per day, given in two equal doses or a control group who did not receive this drug. The study was conducted for a period of 12 weeks. Patients were evaluated by measurement of fasting plasma lipid levels before and after the use of Omega-3. There was a significant (28%) increase in high-density lipoprotein levels (P %) decrease in serum TG levels (P < 0.02) in the group that received Omega-3 supplement. There were no changes in total cholesterol or low-density lipoprotein levels in either group. Our study suggests that supplementation with low-dose Omega-3 has a favorable effect on plasma lipid levels in patients on HD. SN - 1319-2442 UR - https://www.unboundmedicine.com/medline/citation/17951945/The_effect_of_low_dose_omega_3_on_plasma_lipids_in_hemodialysis_patients_ L2 - http://www.sjkdt.org/article.asp?issn=1319-2442;year=2007;volume=18;issue=4;spage=571;epage=576;aulast=Taziki DB - PRIME DP - Unbound Medicine ER -