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The endocannabinoid system and Alzheimer's disease.
Mol Neurobiol. 2007 Aug; 36(1):75-81.MN

Abstract

The importance of the role of the endocannabinoid system (ECS) in neurodegenerative diseases has grown during the past few years. Mostly because of the high density and wide distribution of cannabinoid receptors of the CB(1) type in the central nervous system (CNS), much research focused on the function(s) that these receptors might play in pathophysiological conditions. Our current understanding, however, points to much diverse roles for this system. In particular, other elements of the ECS, such as the fatty acid amide hydrolase (FAAH) or the CB(2) cannabinoid receptor are now considered as promising pharmacological targets for some diseases and new cannabinoids have been incorporated as therapeutic tools. Although still preliminary, recent reports suggest that the modulation of the ECS may constitute a novel approach for the treatment of Alzheimer's disease (AD). Data obtained in vitro, as well as in animal models for this disease and in human samples seem to corroborate the notion that the activation of the ECS, through the use of agonists or by enhancing the endogenous cannabinoid tone, may induce beneficial effects on the evolution of this disease.

Authors+Show Affiliations

Laboratorio de Apoyo a la Investigación, Fundación Hospital Alcorcón, C/ Budapest 1, 28922 Alcorcón, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17952652

Citation

Benito, Cristina, et al. "The Endocannabinoid System and Alzheimer's Disease." Molecular Neurobiology, vol. 36, no. 1, 2007, pp. 75-81.
Benito C, Núñez E, Pazos MR, et al. The endocannabinoid system and Alzheimer's disease. Mol Neurobiol. 2007;36(1):75-81.
Benito, C., Núñez, E., Pazos, M. R., Tolón, R. M., & Romero, J. (2007). The endocannabinoid system and Alzheimer's disease. Molecular Neurobiology, 36(1), 75-81.
Benito C, et al. The Endocannabinoid System and Alzheimer's Disease. Mol Neurobiol. 2007;36(1):75-81. PubMed PMID: 17952652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The endocannabinoid system and Alzheimer's disease. AU - Benito,Cristina, AU - Núñez,Estefanía, AU - Pazos,María Ruth, AU - Tolón,Rosa María, AU - Romero,Julián, Y1 - 2007/09/05/ PY - 2007/01/31/received PY - 2007/06/21/accepted PY - 2007/10/24/pubmed PY - 2007/12/19/medline PY - 2007/10/24/entrez SP - 75 EP - 81 JF - Molecular neurobiology JO - Mol. Neurobiol. VL - 36 IS - 1 N2 - The importance of the role of the endocannabinoid system (ECS) in neurodegenerative diseases has grown during the past few years. Mostly because of the high density and wide distribution of cannabinoid receptors of the CB(1) type in the central nervous system (CNS), much research focused on the function(s) that these receptors might play in pathophysiological conditions. Our current understanding, however, points to much diverse roles for this system. In particular, other elements of the ECS, such as the fatty acid amide hydrolase (FAAH) or the CB(2) cannabinoid receptor are now considered as promising pharmacological targets for some diseases and new cannabinoids have been incorporated as therapeutic tools. Although still preliminary, recent reports suggest that the modulation of the ECS may constitute a novel approach for the treatment of Alzheimer's disease (AD). Data obtained in vitro, as well as in animal models for this disease and in human samples seem to corroborate the notion that the activation of the ECS, through the use of agonists or by enhancing the endogenous cannabinoid tone, may induce beneficial effects on the evolution of this disease. SN - 0893-7648 UR - https://www.unboundmedicine.com/medline/citation/17952652/The_endocannabinoid_system_and_Alzheimer's_disease_ L2 - https://dx.doi.org/10.1007/s12035-007-8006-8 DB - PRIME DP - Unbound Medicine ER -