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The endocannabinoid system and extinction learning.
Mol Neurobiol. 2007 Aug; 36(1):92-101.MN

Abstract

The endocannabinoid system has emerged as a versatile neuromodulatory system, implicated in a plethora of physiological and pathophysiological processes. Cannabinoid receptor type 1 (CB1 receptor) and endocannabinoids are widely distributed in the brain. Their roles in learning and memory have been well documented, using rodents in various memory tests. Depending on the test, the endocannabinoid system is required in the acquisition and/or extinction of memory. In particular, the activation of CB1 receptor-mediated signaling is centrally involved in the facilitation of behavioral adaptation after the acquisition of aversive memories. As several human psychiatric disorders, such as phobia, generalized anxiety disorders, and posttraumatic stress disorder (PTSD) appear to involve aberrant memory processing and impaired adaptation to changed environmental conditions, the hope has been fuelled that the endocannabinoid system might be a valuable therapeutic target for the treatment of these disorders. This review summarizes the current data on the role of the endocannabinoid system in the modulation of extinction learning.

Authors+Show Affiliations

Department of Physiological Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 6, D-55099 Mainz, Germany. blutz@uni-mainz.de

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17952654

Citation

Lutz, Beat. "The Endocannabinoid System and Extinction Learning." Molecular Neurobiology, vol. 36, no. 1, 2007, pp. 92-101.
Lutz B. The endocannabinoid system and extinction learning. Mol Neurobiol. 2007;36(1):92-101.
Lutz, B. (2007). The endocannabinoid system and extinction learning. Molecular Neurobiology, 36(1), 92-101.
Lutz B. The Endocannabinoid System and Extinction Learning. Mol Neurobiol. 2007;36(1):92-101. PubMed PMID: 17952654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The endocannabinoid system and extinction learning. A1 - Lutz,Beat, Y1 - 2007/08/17/ PY - 2007/02/02/received PY - 2007/07/20/accepted PY - 2007/10/24/pubmed PY - 2007/12/19/medline PY - 2007/10/24/entrez SP - 92 EP - 101 JF - Molecular neurobiology JO - Mol. Neurobiol. VL - 36 IS - 1 N2 - The endocannabinoid system has emerged as a versatile neuromodulatory system, implicated in a plethora of physiological and pathophysiological processes. Cannabinoid receptor type 1 (CB1 receptor) and endocannabinoids are widely distributed in the brain. Their roles in learning and memory have been well documented, using rodents in various memory tests. Depending on the test, the endocannabinoid system is required in the acquisition and/or extinction of memory. In particular, the activation of CB1 receptor-mediated signaling is centrally involved in the facilitation of behavioral adaptation after the acquisition of aversive memories. As several human psychiatric disorders, such as phobia, generalized anxiety disorders, and posttraumatic stress disorder (PTSD) appear to involve aberrant memory processing and impaired adaptation to changed environmental conditions, the hope has been fuelled that the endocannabinoid system might be a valuable therapeutic target for the treatment of these disorders. This review summarizes the current data on the role of the endocannabinoid system in the modulation of extinction learning. SN - 0893-7648 UR - https://www.unboundmedicine.com/medline/citation/17952654/The_endocannabinoid_system_and_extinction_learning_ L2 - https://dx.doi.org/10.1007/s12035-007-8004-x DB - PRIME DP - Unbound Medicine ER -