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In vitro antimicrobial activity of a novel propolis formulation (Actichelated propolis).
J Appl Microbiol. 2007 Nov; 103(5):1914-21.JA

Abstract

AIMS

This study compared in vitro activities of Actichelated propolis (a multicomposite material obtained with mechano-chemichal activation) and of a hydroalcoholic extract of propolis.

METHODS AND RESULTS

Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), determined by means of microdilution broth method, against five strains of Staphylococcus aureus, Streptococcus pyogenes, Haemophilus influenzae, Enterococcus spp., Escherichia coli, Proteus mirabilis and Pseudomonas aeruginosa, showed a greater potency of Actichelated propolis (MIC range: 0.016-4 mg flavonoids ml(-1)) in respect to the hydroalcoholic extract (MIC range: 0.08-21.4 mg flavonoids ml(-1)). Concentrations of Actichelated propolis active against adenovirus, influenza virus, parainfluenza virus and herpes virus type 1 were at least 10 times lower than those of the hydroalcoholic extract. Preincubation of Strep. pyogenes and H. influenzae with subinhibitory concentrations of Actichelated propolis (1/4 and 1/8 x MIC) significantly reduced the number of bacteria that adhered to human buccal cells.

CONCLUSIONS

Actichelated propolis has proven to possess antibacterial and antiviral activity higher than a hydroalcoholic extract, being also able to interfere on bacterial adhesion to human oral cells.

SIGNIFICANCE AND IMPACT OF THE STUDY

This new formulation of propolis showing better antimicrobial and physical characteristics could improve the application of propolis in respiratory tract infections.

Authors+Show Affiliations

Dept of Preclinical Science LITA Vialba, University of Milan, Milano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17953601

Citation

Drago, L, et al. "In Vitro Antimicrobial Activity of a Novel Propolis Formulation (Actichelated Propolis)." Journal of Applied Microbiology, vol. 103, no. 5, 2007, pp. 1914-21.
Drago L, De Vecchi E, Nicola L, et al. In vitro antimicrobial activity of a novel propolis formulation (Actichelated propolis). J Appl Microbiol. 2007;103(5):1914-21.
Drago, L., De Vecchi, E., Nicola, L., & Gismondo, M. R. (2007). In vitro antimicrobial activity of a novel propolis formulation (Actichelated propolis). Journal of Applied Microbiology, 103(5), 1914-21.
Drago L, et al. In Vitro Antimicrobial Activity of a Novel Propolis Formulation (Actichelated Propolis). J Appl Microbiol. 2007;103(5):1914-21. PubMed PMID: 17953601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro antimicrobial activity of a novel propolis formulation (Actichelated propolis). AU - Drago,L, AU - De Vecchi,E, AU - Nicola,L, AU - Gismondo,M R, PY - 2007/10/24/pubmed PY - 2008/4/4/medline PY - 2007/10/24/entrez SP - 1914 EP - 21 JF - Journal of applied microbiology JO - J. Appl. Microbiol. VL - 103 IS - 5 N2 - AIMS: This study compared in vitro activities of Actichelated propolis (a multicomposite material obtained with mechano-chemichal activation) and of a hydroalcoholic extract of propolis. METHODS AND RESULTS: Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), determined by means of microdilution broth method, against five strains of Staphylococcus aureus, Streptococcus pyogenes, Haemophilus influenzae, Enterococcus spp., Escherichia coli, Proteus mirabilis and Pseudomonas aeruginosa, showed a greater potency of Actichelated propolis (MIC range: 0.016-4 mg flavonoids ml(-1)) in respect to the hydroalcoholic extract (MIC range: 0.08-21.4 mg flavonoids ml(-1)). Concentrations of Actichelated propolis active against adenovirus, influenza virus, parainfluenza virus and herpes virus type 1 were at least 10 times lower than those of the hydroalcoholic extract. Preincubation of Strep. pyogenes and H. influenzae with subinhibitory concentrations of Actichelated propolis (1/4 and 1/8 x MIC) significantly reduced the number of bacteria that adhered to human buccal cells. CONCLUSIONS: Actichelated propolis has proven to possess antibacterial and antiviral activity higher than a hydroalcoholic extract, being also able to interfere on bacterial adhesion to human oral cells. SIGNIFICANCE AND IMPACT OF THE STUDY: This new formulation of propolis showing better antimicrobial and physical characteristics could improve the application of propolis in respiratory tract infections. SN - 1364-5072 UR - https://www.unboundmedicine.com/medline/citation/17953601/In_vitro_antimicrobial_activity_of_a_novel_propolis_formulation__Actichelated_propolis__ L2 - https://doi.org/10.1111/j.1365-2672.2007.03421.x DB - PRIME DP - Unbound Medicine ER -