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Targeted UVB phototherapy for psoriasis: a preliminary study.
Clin Exp Dermatol. 2007 Nov; 32(6):642-5.CE

Abstract

Excimer laser treatment for psoriasis has been associated with good results at a lower cumulative dose than narrowband ultraviolet (UV)B protocols. To examine the clinical performance of a new targeted UVB lamp (290-320 nm; BClear) in the treatment of plaque-type psoriasis, 28 consecutive patients attending a dermatology service were treated twice weekly with the UVB lamp for 6-18 sessions (median 10). UV doses were based on multiples of a predetermined minimal erythema dose (MED). MEDs ranged from 150 to 350 mJ/cm2; maximal dose was 8 MED. Mean cumulative fluence until remission was 12.63 J/cm2. The Psoriasis Severity Index (PSI) was measured every 2 weeks for 16 weeks. Mean PSI improvement during treatment peaked at 73% after 6 weeks, and declined to 63% at 16 weeks. At that point, 36% of the patients had a > 75% improvement in PSI, and 21% showed complete clearance. Targeted radiation with the UVB lamp is effective for the treatment of plaque-type psoriasis, requiring as few as six sessions and achieving moderately long remission. As treatment is selectively directed toward lesioned skin, normal surrounding skin is spared unnecessary radiation exposure.

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Authors+Show Affiliations

Lapidoth M
Dermatological Laser Clinic, Herzliya Medical Center, Herzeliya, Israel. alapidot@netvision.net.il
Adatto M
No affiliation info available
David M
No affiliation info available

MeSH

AdultAgedErythemaFemaleFollow-Up StudiesHumansMaleMiddle AgedPsoriasisRadiation InjuriesRadiotherapy DosageSeverity of Illness IndexTreatment OutcomeUltraviolet Therapy

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

17953632

Citation

Lapidoth, M, et al. "Targeted UVB Phototherapy for Psoriasis: a Preliminary Study." Clinical and Experimental Dermatology, vol. 32, no. 6, 2007, pp. 642-5.
Lapidoth M, Adatto M, David M. Targeted UVB phototherapy for psoriasis: a preliminary study. Clin Exp Dermatol. 2007;32(6):642-5.
Lapidoth, M., Adatto, M., & David, M. (2007). Targeted UVB phototherapy for psoriasis: a preliminary study. Clinical and Experimental Dermatology, 32(6), 642-5.
Lapidoth M, Adatto M, David M. Targeted UVB Phototherapy for Psoriasis: a Preliminary Study. Clin Exp Dermatol. 2007;32(6):642-5. PubMed PMID: 17953632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Targeted UVB phototherapy for psoriasis: a preliminary study. AU - Lapidoth,M, AU - Adatto,M, AU - David,M, PY - 2007/10/24/pubmed PY - 2008/4/4/medline PY - 2007/10/24/entrez SP - 642 EP - 5 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 32 IS - 6 N2 - Excimer laser treatment for psoriasis has been associated with good results at a lower cumulative dose than narrowband ultraviolet (UV)B protocols. To examine the clinical performance of a new targeted UVB lamp (290-320 nm; BClear) in the treatment of plaque-type psoriasis, 28 consecutive patients attending a dermatology service were treated twice weekly with the UVB lamp for 6-18 sessions (median 10). UV doses were based on multiples of a predetermined minimal erythema dose (MED). MEDs ranged from 150 to 350 mJ/cm2; maximal dose was 8 MED. Mean cumulative fluence until remission was 12.63 J/cm2. The Psoriasis Severity Index (PSI) was measured every 2 weeks for 16 weeks. Mean PSI improvement during treatment peaked at 73% after 6 weeks, and declined to 63% at 16 weeks. At that point, 36% of the patients had a > 75% improvement in PSI, and 21% showed complete clearance. Targeted radiation with the UVB lamp is effective for the treatment of plaque-type psoriasis, requiring as few as six sessions and achieving moderately long remission. As treatment is selectively directed toward lesioned skin, normal surrounding skin is spared unnecessary radiation exposure. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/17953632/Targeted_UVB_phototherapy_for_psoriasis:_a_preliminary_study_ L2 - https://doi.org/10.1111/j.1365-2230.2007.02469.x DB - PRIME DP - Unbound Medicine ER -