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Targeted UVB phototherapy for psoriasis: a preliminary study.

Abstract

Excimer laser treatment for psoriasis has been associated with good results at a lower cumulative dose than narrowband ultraviolet (UV)B protocols. To examine the clinical performance of a new targeted UVB lamp (290-320 nm; BClear) in the treatment of plaque-type psoriasis, 28 consecutive patients attending a dermatology service were treated twice weekly with the UVB lamp for 6-18 sessions (median 10). UV doses were based on multiples of a predetermined minimal erythema dose (MED). MEDs ranged from 150 to 350 mJ/cm2; maximal dose was 8 MED. Mean cumulative fluence until remission was 12.63 J/cm2. The Psoriasis Severity Index (PSI) was measured every 2 weeks for 16 weeks. Mean PSI improvement during treatment peaked at 73% after 6 weeks, and declined to 63% at 16 weeks. At that point, 36% of the patients had a > 75% improvement in PSI, and 21% showed complete clearance. Targeted radiation with the UVB lamp is effective for the treatment of plaque-type psoriasis, requiring as few as six sessions and achieving moderately long remission. As treatment is selectively directed toward lesioned skin, normal surrounding skin is spared unnecessary radiation exposure.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Dermatological Laser Clinic, Herzliya Medical Center, Herzeliya, Israel. alapidot@netvision.net.il

    ,

    Source

    MeSH

    Adult
    Aged
    Erythema
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Psoriasis
    Radiation Injuries
    Radiotherapy Dosage
    Severity of Illness Index
    Treatment Outcome
    Ultraviolet Therapy

    Pub Type(s)

    Evaluation Studies
    Journal Article

    Language

    eng

    PubMed ID

    17953632

    Citation

    Lapidoth, M, et al. "Targeted UVB Phototherapy for Psoriasis: a Preliminary Study." Clinical and Experimental Dermatology, vol. 32, no. 6, 2007, pp. 642-5.
    Lapidoth M, Adatto M, David M. Targeted UVB phototherapy for psoriasis: a preliminary study. Clin Exp Dermatol. 2007;32(6):642-5.
    Lapidoth, M., Adatto, M., & David, M. (2007). Targeted UVB phototherapy for psoriasis: a preliminary study. Clinical and Experimental Dermatology, 32(6), pp. 642-5.
    Lapidoth M, Adatto M, David M. Targeted UVB Phototherapy for Psoriasis: a Preliminary Study. Clin Exp Dermatol. 2007;32(6):642-5. PubMed PMID: 17953632.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Targeted UVB phototherapy for psoriasis: a preliminary study. AU - Lapidoth,M, AU - Adatto,M, AU - David,M, PY - 2007/10/24/pubmed PY - 2008/4/4/medline PY - 2007/10/24/entrez SP - 642 EP - 5 JF - Clinical and experimental dermatology JO - Clin. Exp. Dermatol. VL - 32 IS - 6 N2 - Excimer laser treatment for psoriasis has been associated with good results at a lower cumulative dose than narrowband ultraviolet (UV)B protocols. To examine the clinical performance of a new targeted UVB lamp (290-320 nm; BClear) in the treatment of plaque-type psoriasis, 28 consecutive patients attending a dermatology service were treated twice weekly with the UVB lamp for 6-18 sessions (median 10). UV doses were based on multiples of a predetermined minimal erythema dose (MED). MEDs ranged from 150 to 350 mJ/cm2; maximal dose was 8 MED. Mean cumulative fluence until remission was 12.63 J/cm2. The Psoriasis Severity Index (PSI) was measured every 2 weeks for 16 weeks. Mean PSI improvement during treatment peaked at 73% after 6 weeks, and declined to 63% at 16 weeks. At that point, 36% of the patients had a > 75% improvement in PSI, and 21% showed complete clearance. Targeted radiation with the UVB lamp is effective for the treatment of plaque-type psoriasis, requiring as few as six sessions and achieving moderately long remission. As treatment is selectively directed toward lesioned skin, normal surrounding skin is spared unnecessary radiation exposure. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/17953632/Targeted_UVB_phototherapy_for_psoriasis:_a_preliminary_study_ L2 - https://doi.org/10.1111/j.1365-2230.2007.02469.x DB - PRIME DP - Unbound Medicine ER -