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Candida spp. colonization and serum anticandidal antibody levels in patients with chronic urticaria.
Clin Exp Dermatol. 2007 Nov; 32(6):740-3.CE

Abstract

BACKGROUND

The role of Candida infections in the pathogenesis of chronic urticaria (CU) is debatable. Objective. In this study, we investigated the role of Candida spp. colonization and infection in patients with CU.

METHODS

In total, 38 patients with CU and a control group of 42 healthy individuals consented for inclusion in the study. Stool and oral specimens from all participants were cultured and evaluated quantitatively. Candida albicans ELISA IgG/IgM/IgA test kits were used for the detection of antibodies against C. albicans in the sera of patients and controls.

RESULTS

Yeasts were isolated from the stools of 60.5% of the patients and 50.0% of the controls (P = 0.78, Student's t-test) and from oral specimens in 47.4% and 42.9% (P = 0.85, Student's t-test), respectively. Colony counts in the positive specimens of both groups were not significantly different. IgG, IgM and IgA antibodies were positive in 36.8%, 23.8% and 5.3% of the patients and in 42.9%, 19.1% and 4.8% of the controls, respectively. The qualitative and quantitative results of the antibodies were not significantly different between the two groups (chi2 test).

CONCLUSION

Intestinal and oral colonization of Candida spp. and serological evidence of Candida infections were not significantly different between patients with CU and controls. Claims of triggering of CU by Candida spp. should be explored in studies that measure allergic reactivity to Candida, and also in those that include eradication therapy.

Authors+Show Affiliations

Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey. cem.ergon@deu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17953642

Citation

Ergon, M C., et al. "Candida Spp. Colonization and Serum Anticandidal Antibody Levels in Patients With Chronic Urticaria." Clinical and Experimental Dermatology, vol. 32, no. 6, 2007, pp. 740-3.
Ergon MC, iĺknur T, Yućesoy M, et al. Candida spp. colonization and serum anticandidal antibody levels in patients with chronic urticaria. Clin Exp Dermatol. 2007;32(6):740-3.
Ergon, M. C., iĺknur, T., Yućesoy, M., & Oźkan, S. (2007). Candida spp. colonization and serum anticandidal antibody levels in patients with chronic urticaria. Clinical and Experimental Dermatology, 32(6), 740-3.
Ergon MC, et al. Candida Spp. Colonization and Serum Anticandidal Antibody Levels in Patients With Chronic Urticaria. Clin Exp Dermatol. 2007;32(6):740-3. PubMed PMID: 17953642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Candida spp. colonization and serum anticandidal antibody levels in patients with chronic urticaria. AU - Ergon,M C, AU - iĺknur,T, AU - Yućesoy,M, AU - Oźkan,S, PY - 2007/10/24/pubmed PY - 2008/4/4/medline PY - 2007/10/24/entrez SP - 740 EP - 3 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 32 IS - 6 N2 - BACKGROUND: The role of Candida infections in the pathogenesis of chronic urticaria (CU) is debatable. Objective. In this study, we investigated the role of Candida spp. colonization and infection in patients with CU. METHODS: In total, 38 patients with CU and a control group of 42 healthy individuals consented for inclusion in the study. Stool and oral specimens from all participants were cultured and evaluated quantitatively. Candida albicans ELISA IgG/IgM/IgA test kits were used for the detection of antibodies against C. albicans in the sera of patients and controls. RESULTS: Yeasts were isolated from the stools of 60.5% of the patients and 50.0% of the controls (P = 0.78, Student's t-test) and from oral specimens in 47.4% and 42.9% (P = 0.85, Student's t-test), respectively. Colony counts in the positive specimens of both groups were not significantly different. IgG, IgM and IgA antibodies were positive in 36.8%, 23.8% and 5.3% of the patients and in 42.9%, 19.1% and 4.8% of the controls, respectively. The qualitative and quantitative results of the antibodies were not significantly different between the two groups (chi2 test). CONCLUSION: Intestinal and oral colonization of Candida spp. and serological evidence of Candida infections were not significantly different between patients with CU and controls. Claims of triggering of CU by Candida spp. should be explored in studies that measure allergic reactivity to Candida, and also in those that include eradication therapy. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/17953642/Candida_spp__colonization_and_serum_anticandidal_antibody_levels_in_patients_with_chronic_urticaria_ L2 - https://doi.org/10.1111/j.1365-2230.2007.02512.x DB - PRIME DP - Unbound Medicine ER -