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Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization.
Ophthalmology. 2008 Jun; 115(6):1046-1052.e2.O

Abstract

PURPOSE

To investigate the association of cardiovascular risk factors and inflammatory markers with neovascular age-related macular degeneration (AMD).

DESIGN

Cross-sectional case-control study.

PARTICIPANTS

Of the 410 of the >/=65-year-old community sample invited to attend, 205 participated (50% response rate). Of the 215 clinic attendees who were invited to participate, 212 agreed to take part (98% response rate). A diagnosis of neovascular AMD in at least one eye was made in 193 clinic attendees and 2 of the community sample.

METHODS

Clinic and community participants underwent a detailed ophthalmic examination with fundus imaging, were interviewed for assessment of putative risk factors, and provided a blood sample. Analysis included levels of serum lipids, intercellular adhesion molecule 1 (ICAM), vascular cellular adhesion molecule (VCAM), and C-reactive protein (CRP). All participants were classified by fundus image grading on the basis of the eye with more severe AMD features.

MAIN OUTCOME MEASURE

Neovascular AMD.

RESULTS

There were 195 participants with choroidal neovascularization in at least one eye, 97 nonneovascular AMD participants, and 115 controls (no drusen or pigmentary irregularities in either eye). In confounder-adjusted logistic regression, a history of cardiovascular disease was strongly associated with neovascular AMD (odds ratio [OR], 7.53; 95% confidence interval [CI], 2.78-20.41). Cigarette smoking (OR, 3.71; 95% CI, 1.25-11.06), being in the highest quartile of body mass index (OR, 3.82; 95% CI, 1.22-12.01), stage 2 hypertension (OR, 3.21; 95% CI, 1.14-8.98), and being in the highest quartile of serum cholesterol (OR, 4.66; 95% CI, 1.35-16.13) were positively associated with neovascular AMD. There was no association between AMD status and serum CRP, ICAM, or VCAM.

CONCLUSIONS

Our results suggest that cardiovascular disease plays an etiological role in the development of choroidal neovascularization in a proportion of older adults and highlight the importance of control of blood pressure and cholesterol, avoidance of smoking, and maintenance of a normal body weight.

Authors+Show Affiliations

Centre for Vision Sciences, Belfast, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17953990

Citation

Hogg, Ruth E., et al. "Cardiovascular Disease and Hypertension Are Strong Risk Factors for Choroidal Neovascularization." Ophthalmology, vol. 115, no. 6, 2008, pp. 1046-1052.e2.
Hogg RE, Woodside JV, Gilchrist SE, et al. Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization. Ophthalmology. 2008;115(6):1046-1052.e2.
Hogg, R. E., Woodside, J. V., Gilchrist, S. E., Graydon, R., Fletcher, A. E., Chan, W., Knox, A., Cartmill, B., & Chakravarthy, U. (2008). Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization. Ophthalmology, 115(6), 1046-e2.
Hogg RE, et al. Cardiovascular Disease and Hypertension Are Strong Risk Factors for Choroidal Neovascularization. Ophthalmology. 2008;115(6):1046-1052.e2. PubMed PMID: 17953990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization. AU - Hogg,Ruth E, AU - Woodside,Jayne V, AU - Gilchrist,Sarah E C M, AU - Graydon,Ryan, AU - Fletcher,Astrid E, AU - Chan,Wing, AU - Knox,Angela, AU - Cartmill,Barry, AU - Chakravarthy,Usha, Y1 - 2007/10/22/ PY - 2006/12/07/received PY - 2007/06/06/revised PY - 2007/07/27/accepted PY - 2007/10/24/pubmed PY - 2008/6/13/medline PY - 2007/10/24/entrez SP - 1046 EP - 1052.e2 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 6 N2 - PURPOSE: To investigate the association of cardiovascular risk factors and inflammatory markers with neovascular age-related macular degeneration (AMD). DESIGN: Cross-sectional case-control study. PARTICIPANTS: Of the 410 of the >/=65-year-old community sample invited to attend, 205 participated (50% response rate). Of the 215 clinic attendees who were invited to participate, 212 agreed to take part (98% response rate). A diagnosis of neovascular AMD in at least one eye was made in 193 clinic attendees and 2 of the community sample. METHODS: Clinic and community participants underwent a detailed ophthalmic examination with fundus imaging, were interviewed for assessment of putative risk factors, and provided a blood sample. Analysis included levels of serum lipids, intercellular adhesion molecule 1 (ICAM), vascular cellular adhesion molecule (VCAM), and C-reactive protein (CRP). All participants were classified by fundus image grading on the basis of the eye with more severe AMD features. MAIN OUTCOME MEASURE: Neovascular AMD. RESULTS: There were 195 participants with choroidal neovascularization in at least one eye, 97 nonneovascular AMD participants, and 115 controls (no drusen or pigmentary irregularities in either eye). In confounder-adjusted logistic regression, a history of cardiovascular disease was strongly associated with neovascular AMD (odds ratio [OR], 7.53; 95% confidence interval [CI], 2.78-20.41). Cigarette smoking (OR, 3.71; 95% CI, 1.25-11.06), being in the highest quartile of body mass index (OR, 3.82; 95% CI, 1.22-12.01), stage 2 hypertension (OR, 3.21; 95% CI, 1.14-8.98), and being in the highest quartile of serum cholesterol (OR, 4.66; 95% CI, 1.35-16.13) were positively associated with neovascular AMD. There was no association between AMD status and serum CRP, ICAM, or VCAM. CONCLUSIONS: Our results suggest that cardiovascular disease plays an etiological role in the development of choroidal neovascularization in a proportion of older adults and highlight the importance of control of blood pressure and cholesterol, avoidance of smoking, and maintenance of a normal body weight. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17953990/Cardiovascular_disease_and_hypertension_are_strong_risk_factors_for_choroidal_neovascularization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)00847-0 DB - PRIME DP - Unbound Medicine ER -