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Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry.
Rapid Commun Mass Spectrom. 2007; 21(22):3716-20.RC

Abstract

A simple method for the simultaneous identification and quantification of four 2,5-methylenedioxy derivatives of 4-thioamphetamine (ALEPH series) in plasma samples was developed. The method consists of solid-phase extraction (SPE) using a Bond Elut C(18) cartridge and capillary electrophoresis coupled with electrospray ionisation mass spectrometry (CE/ESI-MS). The SPE method used required only simple steps and provided a clean extract from which identification of each drug was feasible, even at low concentrations. The method was validated according to international guidelines. The calibration curves were linear over the concentration range of 50 to 1000 ng/mL for all drugs with correlation coefficients that exceeded 0.998. The lower limits of detection of the drugs were 23-43 ng/mL. The absolute recoveries for the drugs were 64-92% and 75-96% at concentrations of 100 and 500 ng/mL, respectively. The validation data (precision, accuracy, and recovery) show the reproducibility and selectivity of the method. This clean and simple method allows the routine detection of designer drugs such as thioamphetamines which may become a serious problem in the control of illegal drugs.

Authors+Show Affiliations

Dipartimento Farmaco Chimico Tossicologico, Università degli Studi di Sassari, Via Muroni 23, 07100 Sassari, Italy. gboatto@uniss.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

17955568

Citation

Boatto, Gianpiero, et al. "Simultaneous Determination of New Thioamphetamine Designer Drugs in Plasma By Capillary Electrophoresis Coupled With Mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 21, no. 22, 2007, pp. 3716-20.
Boatto G, Nieddu M, Pirisi MA, et al. Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry. Rapid Commun Mass Spectrom. 2007;21(22):3716-20.
Boatto, G., Nieddu, M., Pirisi, M. A., & Dessì, G. (2007). Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 21(22), 3716-20.
Boatto G, et al. Simultaneous Determination of New Thioamphetamine Designer Drugs in Plasma By Capillary Electrophoresis Coupled With Mass Spectrometry. Rapid Commun Mass Spectrom. 2007;21(22):3716-20. PubMed PMID: 17955568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry. AU - Boatto,Gianpiero, AU - Nieddu,Maria, AU - Pirisi,Maria Antonietta, AU - Dessì,Giuseppina, PY - 2007/10/24/pubmed PY - 2007/12/19/medline PY - 2007/10/24/entrez SP - 3716 EP - 20 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 21 IS - 22 N2 - A simple method for the simultaneous identification and quantification of four 2,5-methylenedioxy derivatives of 4-thioamphetamine (ALEPH series) in plasma samples was developed. The method consists of solid-phase extraction (SPE) using a Bond Elut C(18) cartridge and capillary electrophoresis coupled with electrospray ionisation mass spectrometry (CE/ESI-MS). The SPE method used required only simple steps and provided a clean extract from which identification of each drug was feasible, even at low concentrations. The method was validated according to international guidelines. The calibration curves were linear over the concentration range of 50 to 1000 ng/mL for all drugs with correlation coefficients that exceeded 0.998. The lower limits of detection of the drugs were 23-43 ng/mL. The absolute recoveries for the drugs were 64-92% and 75-96% at concentrations of 100 and 500 ng/mL, respectively. The validation data (precision, accuracy, and recovery) show the reproducibility and selectivity of the method. This clean and simple method allows the routine detection of designer drugs such as thioamphetamines which may become a serious problem in the control of illegal drugs. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/17955568/Simultaneous_determination_of_new_thioamphetamine_designer_drugs_in_plasma_by_capillary_electrophoresis_coupled_with_mass_spectrometry_ L2 - https://doi.org/10.1002/rcm.3273 DB - PRIME DP - Unbound Medicine ER -