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Inhibitory effect of cranberry polyphenol on biofilm formation and cysteine proteases of Porphyromonas gingivalis.
J Periodontal Res. 2007 Dec; 42(6):589-92.JP

Abstract

BACKGROUND AND OBJECTIVE

The purpose of this study was to investigate the effects of cranberry polyphenol fraction on biofilm formation and activities of Arg-gingipain and Lys-gingipain in Porphyromonas gingivalis.

MATERIAL AND METHODS

The polyphenol fraction was prepared by using a glass column packed with Amberlite XAD 7HP and 70% aqueous ethanol as an elution solvent.

RESULTS

Synergistic biofilm formation by P. gingivalis and Fusobacterium nucleatum was significantly inhibited by the polyphenol fraction at a concentration of 250 microg/mL compared with untreated controls (p < 0.01). Arg-gingipain and Lys-gingipain activities in P. gingivalis ATCC 33277 and FDC 381 were inhibited significantly at a polyphenol fraction concentration of > or = 1 microg/mL (p < 0.05).

CONCLUSION

These findings indicate that the polyphenol fraction inhibits biofilm formation and the Arg-gingipain and Lys-gingipain activities of P. gingivalis.

Authors+Show Affiliations

Department of Microbiology, Tokyo Dental College, Mihama-ku, Chiba, Japan. aya manak@tdc.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17956474

Citation

Yamanaka, A, et al. "Inhibitory Effect of Cranberry Polyphenol On Biofilm Formation and Cysteine Proteases of Porphyromonas Gingivalis." Journal of Periodontal Research, vol. 42, no. 6, 2007, pp. 589-92.
Yamanaka A, Kouchi T, Kasai K, et al. Inhibitory effect of cranberry polyphenol on biofilm formation and cysteine proteases of Porphyromonas gingivalis. J Periodontal Res. 2007;42(6):589-92.
Yamanaka, A., Kouchi, T., Kasai, K., Kato, T., Ishihara, K., & Okuda, K. (2007). Inhibitory effect of cranberry polyphenol on biofilm formation and cysteine proteases of Porphyromonas gingivalis. Journal of Periodontal Research, 42(6), 589-92.
Yamanaka A, et al. Inhibitory Effect of Cranberry Polyphenol On Biofilm Formation and Cysteine Proteases of Porphyromonas Gingivalis. J Periodontal Res. 2007;42(6):589-92. PubMed PMID: 17956474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of cranberry polyphenol on biofilm formation and cysteine proteases of Porphyromonas gingivalis. AU - Yamanaka,A, AU - Kouchi,T, AU - Kasai,K, AU - Kato,T, AU - Ishihara,K, AU - Okuda,K, PY - 2007/10/25/pubmed PY - 2008/1/3/medline PY - 2007/10/25/entrez SP - 589 EP - 92 JF - Journal of periodontal research JO - J Periodontal Res VL - 42 IS - 6 N2 - BACKGROUND AND OBJECTIVE: The purpose of this study was to investigate the effects of cranberry polyphenol fraction on biofilm formation and activities of Arg-gingipain and Lys-gingipain in Porphyromonas gingivalis. MATERIAL AND METHODS: The polyphenol fraction was prepared by using a glass column packed with Amberlite XAD 7HP and 70% aqueous ethanol as an elution solvent. RESULTS: Synergistic biofilm formation by P. gingivalis and Fusobacterium nucleatum was significantly inhibited by the polyphenol fraction at a concentration of 250 microg/mL compared with untreated controls (p < 0.01). Arg-gingipain and Lys-gingipain activities in P. gingivalis ATCC 33277 and FDC 381 were inhibited significantly at a polyphenol fraction concentration of > or = 1 microg/mL (p < 0.05). CONCLUSION: These findings indicate that the polyphenol fraction inhibits biofilm formation and the Arg-gingipain and Lys-gingipain activities of P. gingivalis. SN - 0022-3484 UR - https://www.unboundmedicine.com/medline/citation/17956474/Inhibitory_effect_of_cranberry_polyphenol_on_biofilm_formation_and_cysteine_proteases_of_Porphyromonas_gingivalis_ L2 - https://doi.org/10.1111/j.1600-0765.2007.00982.x DB - PRIME DP - Unbound Medicine ER -