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The effect of fish and omega-3 LCPUFA intake on low birth weight in Indian pregnant women.
Eur J Clin Nutr. 2009 Mar; 63(3):340-6.EJ

Abstract

BACKGROUND

Inadequate consumption of fish could be a risk factor for low birth weight (LBW). This study assessed fish intake and omega-3 LCPUFA intake and status for their association with LBW in a cohort of urban, south Indian pregnant women.

SUBJECTS/METHODS

In a prospective cohort study, data on maternal fish intake and omega-3 LCPUFA intake and status of 676 women were obtained at baseline (first trimester), the second and third trimesters of pregnancy. Infant birth weight was measured immediately following hospital delivery. The dropout rate was 7.6%.

RESULTS

Fifty-six percent of the study women consumed fish with low daily median intakes (3.4, 4.1 and 3.8 g day(-1) at the three trimesters, respectively). Consequently, the median intakes of EPA and DHA during pregnancy were also low at 2.1 and 10.1 mg day(-1), respectively. EPA and DHA intakes were associated with their status in erythrocyte membrane phospholipids during pregnancy (r=0.40 and 0.36, r=0.34 and 0.32 and r=0.37 and 0.41, at the three trimesters, respectively, all P<0.001). Women who did not eat fish during the third trimester had a significantly higher risk of LBW (OR: 2.49, P=0.019). Similarly, low EPA intake during the third trimester had an association with a higher risk of LBW (OR: 2.75, P=0.011).

CONCLUSIONS

Among low fish-eating pregnant women, fish intake in the third trimester was closely associated with birth weight. Supplementation with omega-3 LCPUFA during pregnancy may have important implications for fetal development in India.

Authors+Show Affiliations

Division of Nutrition, Maternal and Child Health Unit, St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, India. sumithra@iphcr.res.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17957193

Citation

Muthayya, S, et al. "The Effect of Fish and Omega-3 LCPUFA Intake On Low Birth Weight in Indian Pregnant Women." European Journal of Clinical Nutrition, vol. 63, no. 3, 2009, pp. 340-6.
Muthayya S, Dwarkanath P, Thomas T, et al. The effect of fish and omega-3 LCPUFA intake on low birth weight in Indian pregnant women. Eur J Clin Nutr. 2009;63(3):340-6.
Muthayya, S., Dwarkanath, P., Thomas, T., Ramprakash, S., Mehra, R., Mhaskar, A., Mhaskar, R., Thomas, A., Bhat, S., Vaz, M., & Kurpad, A. V. (2009). The effect of fish and omega-3 LCPUFA intake on low birth weight in Indian pregnant women. European Journal of Clinical Nutrition, 63(3), 340-6.
Muthayya S, et al. The Effect of Fish and Omega-3 LCPUFA Intake On Low Birth Weight in Indian Pregnant Women. Eur J Clin Nutr. 2009;63(3):340-6. PubMed PMID: 17957193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of fish and omega-3 LCPUFA intake on low birth weight in Indian pregnant women. AU - Muthayya,S, AU - Dwarkanath,P, AU - Thomas,T, AU - Ramprakash,S, AU - Mehra,R, AU - Mhaskar,A, AU - Mhaskar,R, AU - Thomas,A, AU - Bhat,S, AU - Vaz,M, AU - Kurpad,A V, Y1 - 2007/10/24/ PY - 2007/10/25/pubmed PY - 2009/5/6/medline PY - 2007/10/25/entrez SP - 340 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 63 IS - 3 N2 - BACKGROUND: Inadequate consumption of fish could be a risk factor for low birth weight (LBW). This study assessed fish intake and omega-3 LCPUFA intake and status for their association with LBW in a cohort of urban, south Indian pregnant women. SUBJECTS/METHODS: In a prospective cohort study, data on maternal fish intake and omega-3 LCPUFA intake and status of 676 women were obtained at baseline (first trimester), the second and third trimesters of pregnancy. Infant birth weight was measured immediately following hospital delivery. The dropout rate was 7.6%. RESULTS: Fifty-six percent of the study women consumed fish with low daily median intakes (3.4, 4.1 and 3.8 g day(-1) at the three trimesters, respectively). Consequently, the median intakes of EPA and DHA during pregnancy were also low at 2.1 and 10.1 mg day(-1), respectively. EPA and DHA intakes were associated with their status in erythrocyte membrane phospholipids during pregnancy (r=0.40 and 0.36, r=0.34 and 0.32 and r=0.37 and 0.41, at the three trimesters, respectively, all P<0.001). Women who did not eat fish during the third trimester had a significantly higher risk of LBW (OR: 2.49, P=0.019). Similarly, low EPA intake during the third trimester had an association with a higher risk of LBW (OR: 2.75, P=0.011). CONCLUSIONS: Among low fish-eating pregnant women, fish intake in the third trimester was closely associated with birth weight. Supplementation with omega-3 LCPUFA during pregnancy may have important implications for fetal development in India. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/17957193/The_effect_of_fish_and_omega_3_LCPUFA_intake_on_low_birth_weight_in_Indian_pregnant_women_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602933 DB - PRIME DP - Unbound Medicine ER -