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Critical evaluation of the variants influencing the clinical response of vitiligo: study of 60 cases treated with ultraviolet B narrow-band phototherapy.
J Eur Acad Dermatol Venereol. 2007 Nov; 21(10):1369-74.JE

Abstract

BACKGROUND

The treatment of vitiligo is still a challenge, but ultraviolet B narrow-band (UVB-NB) therapy has been recently reported to be an effective and safe therapeutic option in patients with vitiligo.

OBJECTIVE

The purpose of this study is a critical evaluation of the variants (body sites, age, duration of the disease, and duration of the therapy) influencing the clinical response to UVB-NB therapy.

METHODS

Sixty patients (23 male and 37 female), aged 6 to 70 years, with vitiligo, were treated with UVB-NB therapy over a maximum period of 2 years. The evaluation of the percentage of repigmentation was done through photographs.

RESULTS

The lesions located on the face obtained a complete repigmentation in 68% of the patients, on the neck in 57.89%, and on the trunk in 50% within the first year of the therapy. In young patients vs. adults patients, the lesions located on the neck obtained a complete repigmentation in 83.33% vs. 46.15%, on the upper limbs in 28.57% vs. 9.52%, and on the lower limbs in 25% vs. 16.67%. In patients with vitiligo of recent onset, the lesions located on the neck obtained a complete repigmentation in 83.33%, on the upper limbs in 33.33%, and on the lower limbs in 28.57%. Hands did not give a positive response in either groups.

CONCLUSION

This study shows that certain body sites respond better than others to the UVB-NB therapy; patients, aged less than 20 years, with recent vitiligo, achieve more repigmentation; the duration of the therapy can influence the response of the lesions over hands and lower limbs, showing only mild repigmentation.

Authors+Show Affiliations

Department of Human and Hereditary Pathology, Institute of Dermatology, University of Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy. vbrazzelli@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17958843

Citation

Brazzelli, V, et al. "Critical Evaluation of the Variants Influencing the Clinical Response of Vitiligo: Study of 60 Cases Treated With Ultraviolet B Narrow-band Phototherapy." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 21, no. 10, 2007, pp. 1369-74.
Brazzelli V, Antoninetti M, Palazzini S, et al. Critical evaluation of the variants influencing the clinical response of vitiligo: study of 60 cases treated with ultraviolet B narrow-band phototherapy. J Eur Acad Dermatol Venereol. 2007;21(10):1369-74.
Brazzelli, V., Antoninetti, M., Palazzini, S., Barbagallo, T., De Silvestri, A., & Borroni, G. (2007). Critical evaluation of the variants influencing the clinical response of vitiligo: study of 60 cases treated with ultraviolet B narrow-band phototherapy. Journal of the European Academy of Dermatology and Venereology : JEADV, 21(10), 1369-74.
Brazzelli V, et al. Critical Evaluation of the Variants Influencing the Clinical Response of Vitiligo: Study of 60 Cases Treated With Ultraviolet B Narrow-band Phototherapy. J Eur Acad Dermatol Venereol. 2007;21(10):1369-74. PubMed PMID: 17958843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Critical evaluation of the variants influencing the clinical response of vitiligo: study of 60 cases treated with ultraviolet B narrow-band phototherapy. AU - Brazzelli,V, AU - Antoninetti,M, AU - Palazzini,S, AU - Barbagallo,T, AU - De Silvestri,A, AU - Borroni,G, PY - 2007/10/26/pubmed PY - 2008/3/18/medline PY - 2007/10/26/entrez SP - 1369 EP - 74 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 21 IS - 10 N2 - BACKGROUND: The treatment of vitiligo is still a challenge, but ultraviolet B narrow-band (UVB-NB) therapy has been recently reported to be an effective and safe therapeutic option in patients with vitiligo. OBJECTIVE: The purpose of this study is a critical evaluation of the variants (body sites, age, duration of the disease, and duration of the therapy) influencing the clinical response to UVB-NB therapy. METHODS: Sixty patients (23 male and 37 female), aged 6 to 70 years, with vitiligo, were treated with UVB-NB therapy over a maximum period of 2 years. The evaluation of the percentage of repigmentation was done through photographs. RESULTS: The lesions located on the face obtained a complete repigmentation in 68% of the patients, on the neck in 57.89%, and on the trunk in 50% within the first year of the therapy. In young patients vs. adults patients, the lesions located on the neck obtained a complete repigmentation in 83.33% vs. 46.15%, on the upper limbs in 28.57% vs. 9.52%, and on the lower limbs in 25% vs. 16.67%. In patients with vitiligo of recent onset, the lesions located on the neck obtained a complete repigmentation in 83.33%, on the upper limbs in 33.33%, and on the lower limbs in 28.57%. Hands did not give a positive response in either groups. CONCLUSION: This study shows that certain body sites respond better than others to the UVB-NB therapy; patients, aged less than 20 years, with recent vitiligo, achieve more repigmentation; the duration of the therapy can influence the response of the lesions over hands and lower limbs, showing only mild repigmentation. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/17958843/Critical_evaluation_of_the_variants_influencing_the_clinical_response_of_vitiligo:_study_of_60_cases_treated_with_ultraviolet_B_narrow_band_phototherapy_ L2 - https://doi.org/10.1111/j.1468-3083.2007.02278.x DB - PRIME DP - Unbound Medicine ER -