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HOXA7 in epithelial ovarian cancer: interrelationships between differentiation and clinical features.
Reprod Sci. 2007 Sep; 14(6):605-14.RS

Abstract

Interrelationships between HOXA7 expression and ovarian cancer progression are investigated by cDNA array and by immunohistochemistry of normal ovaries and 538 epithelial ovarian tumor microarrays. Outcomes of patients and HOXA7 expression were compared by Kaplan-Meier survival curves. HOXA7 mRNA expression was higher in carcinomas than in benign tumors. HOXA7 protein was absent in normal surface epithelium but appeared in metaplastic regions. All carcinomas stained for HOXA7 protein, with staining intensities unrelated to histotype, grade, or patient outcome. There were significant associations of strong HOXA7 staining of stroma and tumor nuclei with the clear cell histotype (stroma: P = .0022, nuclei: P = .0003) and of weak/absent staining with serous carcinomas. Tumor E-cadherin expression correlated significantly with HOX7 staining in stroma (P = .0002) but not within tumors. HOXA7 staining of tumor cell nuclei is correlated significantly with improved disease-specific survival (P = .0104), which is suggestive of the biological and potentially clinical importance of subcellular HOXA7 localization.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17959889

Citation

Ota, Takayo, et al. "HOXA7 in Epithelial Ovarian Cancer: Interrelationships Between Differentiation and Clinical Features." Reproductive Sciences (Thousand Oaks, Calif.), vol. 14, no. 6, 2007, pp. 605-14.
Ota T, Gilks CB, Longacre T, et al. HOXA7 in epithelial ovarian cancer: interrelationships between differentiation and clinical features. Reprod Sci. 2007;14(6):605-14.
Ota, T., Gilks, C. B., Longacre, T., Leung, P. C., & Auersperg, N. (2007). HOXA7 in epithelial ovarian cancer: interrelationships between differentiation and clinical features. Reproductive Sciences (Thousand Oaks, Calif.), 14(6), 605-14.
Ota T, et al. HOXA7 in Epithelial Ovarian Cancer: Interrelationships Between Differentiation and Clinical Features. Reprod Sci. 2007;14(6):605-14. PubMed PMID: 17959889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HOXA7 in epithelial ovarian cancer: interrelationships between differentiation and clinical features. AU - Ota,Takayo, AU - Gilks,C Blake, AU - Longacre,Teri, AU - Leung,Peter C K, AU - Auersperg,Nelly, PY - 2007/10/26/pubmed PY - 2007/12/6/medline PY - 2007/10/26/entrez SP - 605 EP - 14 JF - Reproductive sciences (Thousand Oaks, Calif.) JO - Reprod Sci VL - 14 IS - 6 N2 - Interrelationships between HOXA7 expression and ovarian cancer progression are investigated by cDNA array and by immunohistochemistry of normal ovaries and 538 epithelial ovarian tumor microarrays. Outcomes of patients and HOXA7 expression were compared by Kaplan-Meier survival curves. HOXA7 mRNA expression was higher in carcinomas than in benign tumors. HOXA7 protein was absent in normal surface epithelium but appeared in metaplastic regions. All carcinomas stained for HOXA7 protein, with staining intensities unrelated to histotype, grade, or patient outcome. There were significant associations of strong HOXA7 staining of stroma and tumor nuclei with the clear cell histotype (stroma: P = .0022, nuclei: P = .0003) and of weak/absent staining with serous carcinomas. Tumor E-cadherin expression correlated significantly with HOX7 staining in stroma (P = .0002) but not within tumors. HOXA7 staining of tumor cell nuclei is correlated significantly with improved disease-specific survival (P = .0104), which is suggestive of the biological and potentially clinical importance of subcellular HOXA7 localization. SN - 1933-7205 UR - https://www.unboundmedicine.com/medline/citation/17959889/HOXA7_in_epithelial_ovarian_cancer:_interrelationships_between_differentiation_and_clinical_features_ L2 - https://doi.org/10.1177/1933719107307781 DB - PRIME DP - Unbound Medicine ER -