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Gabapentin effectiveness on the sensation of subjective idiopathic tinnitus: a pilot study.
Eur Arch Otorhinolaryngol. 2008 May; 265(5):525-30.EA

Abstract

This prospective, placebo-controlled, double-blind clinical trial evaluated the effectiveness of gabapentin in decreasing subjective features of idiopathic subjective tinnitus in the patients. Pure-tone audiograms, laboratory test and personal histories were used to exclude any particular etiology of tinnitus. Participants were restricted to those with moderate to severe idiopathic subjective tinnitus for at least 6 months. A total of 30 participants received gabapentin in a graduated ascending dose series extending over 4 weeks (peak dose of 900 mg/day). There was not a significant subjective improvement in tinnitus annoyance for the patients (37%) versus controls (42%). Comparison between the results before and after intervention for patients and controls according to subjective response, tinnitus questionnaire, tinnitus severity index and the loudness perception by the patient showed no significant differences (P > 0.05). There is insufficient evidence to support the effectiveness of gabapentin in the treatment of tinnitus up to now.

Authors+Show Affiliations

Otorhinolaryngology-Head and Neck Surgery Department, Imam Reza Educational Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. mehbakhsh@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17960408

Citation

Bakhshaee, Mehdi, et al. "Gabapentin Effectiveness On the Sensation of Subjective Idiopathic Tinnitus: a Pilot Study." European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, vol. 265, no. 5, 2008, pp. 525-30.
Bakhshaee M, Ghasemi M, Azarpazhooh M, et al. Gabapentin effectiveness on the sensation of subjective idiopathic tinnitus: a pilot study. Eur Arch Otorhinolaryngol. 2008;265(5):525-30.
Bakhshaee, M., Ghasemi, M., Azarpazhooh, M., Khadivi, E., Rezaei, S., Shakeri, M., & Tale, M. (2008). Gabapentin effectiveness on the sensation of subjective idiopathic tinnitus: a pilot study. European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 265(5), 525-30.
Bakhshaee M, et al. Gabapentin Effectiveness On the Sensation of Subjective Idiopathic Tinnitus: a Pilot Study. Eur Arch Otorhinolaryngol. 2008;265(5):525-30. PubMed PMID: 17960408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gabapentin effectiveness on the sensation of subjective idiopathic tinnitus: a pilot study. AU - Bakhshaee,Mehdi, AU - Ghasemi,Mohammadmehdi, AU - Azarpazhooh,Mahmoodreza, AU - Khadivi,Ehsan, AU - Rezaei,Saman, AU - Shakeri,Mohammadtaghi, AU - Tale,Mohammadreza, Y1 - 2007/10/25/ PY - 2007/06/10/received PY - 2007/10/09/accepted PY - 2007/10/26/pubmed PY - 2008/8/30/medline PY - 2007/10/26/entrez SP - 525 EP - 30 JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JO - Eur Arch Otorhinolaryngol VL - 265 IS - 5 N2 - This prospective, placebo-controlled, double-blind clinical trial evaluated the effectiveness of gabapentin in decreasing subjective features of idiopathic subjective tinnitus in the patients. Pure-tone audiograms, laboratory test and personal histories were used to exclude any particular etiology of tinnitus. Participants were restricted to those with moderate to severe idiopathic subjective tinnitus for at least 6 months. A total of 30 participants received gabapentin in a graduated ascending dose series extending over 4 weeks (peak dose of 900 mg/day). There was not a significant subjective improvement in tinnitus annoyance for the patients (37%) versus controls (42%). Comparison between the results before and after intervention for patients and controls according to subjective response, tinnitus questionnaire, tinnitus severity index and the loudness perception by the patient showed no significant differences (P > 0.05). There is insufficient evidence to support the effectiveness of gabapentin in the treatment of tinnitus up to now. SN - 0937-4477 UR - https://www.unboundmedicine.com/medline/citation/17960408/Gabapentin_effectiveness_on_the_sensation_of_subjective_idiopathic_tinnitus:_a_pilot_study_ L2 - https://dx.doi.org/10.1007/s00405-007-0504-9 DB - PRIME DP - Unbound Medicine ER -