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Uterine receptivity: alterations associated with benign gynecological disease.
Semin Reprod Med 2007; 25(6):461-75SR

Abstract

The role of the endometrium is to establish and maintain pregnancy. Endometrial receptivity is established during the mid-secretory phase, between cycle day (CD) 20 to 24, or 6 to 10 days after ovulation. In some cases of infertility or recurrent pregnancy loss, implantation failure is due to a lack of expression of specific critical participating proteins such as cell adhesion molecules. Numerous cell adhesion molecules (including integrins, selectins, and cadherins) are expressed by the endometrium and appear to be necessary for the successful interaction of the embryo with the endometrium. One of the best-characterized cell adhesion molecules are the integrins. Integrins are transmembrane glycoproteins that belong to a large family comprising alpha and beta subunits, and are present on virtually all cells in the body. Women with various benign gynecologic disorders, including endometriosis, polycystic ovarian syndrome, hydrosalpinges, and luteal phase defect, appear to exhibit decreased uterine receptivity and abnormal expression of endometrial biomarkers. This review addresses proposed mechanisms of implantation and endocrine and paracrine signals responsible for the establishment of endometrial receptivity as well has the possible mechanisms of dysfunction in certain types of infertility in women with benign gynecologic disease.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

17960531

Citation

Donaghay, Melissa, and Bruce A. Lessey. "Uterine Receptivity: Alterations Associated With Benign Gynecological Disease." Seminars in Reproductive Medicine, vol. 25, no. 6, 2007, pp. 461-75.
Donaghay M, Lessey BA. Uterine receptivity: alterations associated with benign gynecological disease. Semin Reprod Med. 2007;25(6):461-75.
Donaghay, M., & Lessey, B. A. (2007). Uterine receptivity: alterations associated with benign gynecological disease. Seminars in Reproductive Medicine, 25(6), pp. 461-75.
Donaghay M, Lessey BA. Uterine Receptivity: Alterations Associated With Benign Gynecological Disease. Semin Reprod Med. 2007;25(6):461-75. PubMed PMID: 17960531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uterine receptivity: alterations associated with benign gynecological disease. AU - Donaghay,Melissa, AU - Lessey,Bruce A, PY - 2007/10/26/pubmed PY - 2007/12/20/medline PY - 2007/10/26/entrez SP - 461 EP - 75 JF - Seminars in reproductive medicine JO - Semin. Reprod. Med. VL - 25 IS - 6 N2 - The role of the endometrium is to establish and maintain pregnancy. Endometrial receptivity is established during the mid-secretory phase, between cycle day (CD) 20 to 24, or 6 to 10 days after ovulation. In some cases of infertility or recurrent pregnancy loss, implantation failure is due to a lack of expression of specific critical participating proteins such as cell adhesion molecules. Numerous cell adhesion molecules (including integrins, selectins, and cadherins) are expressed by the endometrium and appear to be necessary for the successful interaction of the embryo with the endometrium. One of the best-characterized cell adhesion molecules are the integrins. Integrins are transmembrane glycoproteins that belong to a large family comprising alpha and beta subunits, and are present on virtually all cells in the body. Women with various benign gynecologic disorders, including endometriosis, polycystic ovarian syndrome, hydrosalpinges, and luteal phase defect, appear to exhibit decreased uterine receptivity and abnormal expression of endometrial biomarkers. This review addresses proposed mechanisms of implantation and endocrine and paracrine signals responsible for the establishment of endometrial receptivity as well has the possible mechanisms of dysfunction in certain types of infertility in women with benign gynecologic disease. SN - 1526-8004 UR - https://www.unboundmedicine.com/medline/citation/17960531/Uterine_receptivity:_alterations_associated_with_benign_gynecological_disease_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-991044 DB - PRIME DP - Unbound Medicine ER -