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[Inhibiting effects of GW2974 on DMBA-induced hamster buccal pouch carcinogenesis].
Zhonghua Kou Qiang Yi Xue Za Zhi. 2007 Jul; 42(7):432-5.ZK

Abstract

OBJECTIVE

To evaluate the inhibiting effects of GW2974, a tyrosine kinase inhibitors, on dimethyl-benzanthracene (DMBA)-induced Syrian golden hamster buccal pouch carcinogenesis.

METHODS

Ninety hamsters were painted with 0.5% DMBA in the left buccal pouches three times a week for 6 weeks, which were then divided into 3 groups: low-concentration, high-concentration and positive control groups. Positive control group received no further treatment. Ten hamsters served as negative control. The two treated groups were topically painted with GW2974 (4 mmol/L) and GW2974 (8 mmol/L) three times a week, respectively. Tissue samples of the left cheek pouch were obtained at 24 th week. The average number, average volume and burden of tumor, incidence of tumor and the pathological changes of each group were recorded.

RESULTS

After GW2974 (4 mmol/L and 8 mmol/L) was applied topically, tumor incidence decreased from 80.0% (24/30) to 43.3% (13/30, P < 0.01) and 36.7% (11/30, P < 0.01) respectively, the average number of tumors decreased from 1.00 +/- 0.87 to 0.47 +/- 0.82 (P < 0.05) and 0.37 +/- 0.62 (P < 0.05), the average volume and burden of tumors also declined, tumor incidence decreased from 70.0% (21/30) to 40.0% (12/30, P < 0.05) and 33.3% (10/30, P < 0.01), the number of tumors declined from 1.83 +/- 1.91 to 0.67 +/- 0.99 (P < 0.05) and 0.43 +/- 0.68 (P < 0.01).

CONCLUSIONS

Topical application of GW2974 could significantly inhibit hamster buccal pouch carcinogenesis, which suggests that GW2974 may have a major impact in chemoprevention and treatment of oral cancer.

Authors+Show Affiliations

Department of Oral Medicine, Faculty of Stomatology, Capital University of Medical Sciences, Beijing 100050, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17961367

Citation

Li, Ping, et al. "[Inhibiting Effects of GW2974 On DMBA-induced Hamster Buccal Pouch Carcinogenesis]." Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology, vol. 42, no. 7, 2007, pp. 432-5.
Li P, Ge HB, Sun Z. [Inhibiting effects of GW2974 on DMBA-induced hamster buccal pouch carcinogenesis]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2007;42(7):432-5.
Li, P., Ge, H. B., & Sun, Z. (2007). [Inhibiting effects of GW2974 on DMBA-induced hamster buccal pouch carcinogenesis]. Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology, 42(7), 432-5.
Li P, Ge HB, Sun Z. [Inhibiting Effects of GW2974 On DMBA-induced Hamster Buccal Pouch Carcinogenesis]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2007;42(7):432-5. PubMed PMID: 17961367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Inhibiting effects of GW2974 on DMBA-induced hamster buccal pouch carcinogenesis]. AU - Li,Ping, AU - Ge,Hua-Bing, AU - Sun,Zheng, PY - 2007/10/27/pubmed PY - 2010/6/30/medline PY - 2007/10/27/entrez SP - 432 EP - 5 JF - Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology JO - Zhonghua Kou Qiang Yi Xue Za Zhi VL - 42 IS - 7 N2 - OBJECTIVE: To evaluate the inhibiting effects of GW2974, a tyrosine kinase inhibitors, on dimethyl-benzanthracene (DMBA)-induced Syrian golden hamster buccal pouch carcinogenesis. METHODS: Ninety hamsters were painted with 0.5% DMBA in the left buccal pouches three times a week for 6 weeks, which were then divided into 3 groups: low-concentration, high-concentration and positive control groups. Positive control group received no further treatment. Ten hamsters served as negative control. The two treated groups were topically painted with GW2974 (4 mmol/L) and GW2974 (8 mmol/L) three times a week, respectively. Tissue samples of the left cheek pouch were obtained at 24 th week. The average number, average volume and burden of tumor, incidence of tumor and the pathological changes of each group were recorded. RESULTS: After GW2974 (4 mmol/L and 8 mmol/L) was applied topically, tumor incidence decreased from 80.0% (24/30) to 43.3% (13/30, P < 0.01) and 36.7% (11/30, P < 0.01) respectively, the average number of tumors decreased from 1.00 +/- 0.87 to 0.47 +/- 0.82 (P < 0.05) and 0.37 +/- 0.62 (P < 0.05), the average volume and burden of tumors also declined, tumor incidence decreased from 70.0% (21/30) to 40.0% (12/30, P < 0.05) and 33.3% (10/30, P < 0.01), the number of tumors declined from 1.83 +/- 1.91 to 0.67 +/- 0.99 (P < 0.05) and 0.43 +/- 0.68 (P < 0.01). CONCLUSIONS: Topical application of GW2974 could significantly inhibit hamster buccal pouch carcinogenesis, which suggests that GW2974 may have a major impact in chemoprevention and treatment of oral cancer. SN - 1002-0098 UR - https://www.unboundmedicine.com/medline/citation/17961367/[Inhibiting_effects_of_GW2974_on_DMBA_induced_hamster_buccal_pouch_carcinogenesis]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=1002-0098&amp;year=2007&amp;vol=42&amp;issue=7&amp;fpage=432 DB - PRIME DP - Unbound Medicine ER -