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The effects of atropine on changes in the sleep patterns induced by psychological stress in rats.
Eur J Pharmacol. 2008 Jan 28; 579(1-3):153-9.EJ

Abstract

The present study was designed to investigate the acute effects of psychological stress on the sleep patterns of rats and the potential mechanisms underlying these effects. Psychological stress was induced using a communication box. In a preliminary study, sleep recording was performed for 6 h immediately after 1-h stress in rats. The results showed that psychological stress significantly enhanced the total amount of rapid eye movement (REM) sleep by prolonging the average duration of REM sleep episodes during first 3 h of sleep, whereas the total amount of non-rapid eye movement sleep was not influenced. In a second study, three doses of atropine (3, 10, or 30 nmol) were intracerebroventricularly microinjected into the rats. Total REM sleep was inhibited by the highest dose of atropine during the first 3 h of sleep in the stressed group but not in the control group; the inhibition of total REM sleep was due to a reduction in the average duration of REM sleep episodes. These results suggest that the increase in total REM sleep induced by stress was related to the activation of cholinergic neurons. In addition, plasma corticosterone--an index of hypothalamic-pituitary-adrenal (HPA) axis activity in response to stress--was examined after psychological stress. The concentration of corticosterone did not change significantly. Therefore, the abnormal sleep patterns could not be simply attributed to the HPA axis. These results indicate that the changes in sleep patterns induced by stress were related to cholinergic neurons, but not the HPA axis.

Authors+Show Affiliations

Department of Clinical Pharmacology and Pharmacy, Brain Science, Ehime University Graduate School of Medicine, Shitsukawa Toon, Ehime, 791-0295, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17961548

Citation

Cui, Ranji, et al. "The Effects of Atropine On Changes in the Sleep Patterns Induced By Psychological Stress in Rats." European Journal of Pharmacology, vol. 579, no. 1-3, 2008, pp. 153-9.
Cui R, Suemaru K, Li B, et al. The effects of atropine on changes in the sleep patterns induced by psychological stress in rats. Eur J Pharmacol. 2008;579(1-3):153-9.
Cui, R., Suemaru, K., Li, B., & Araki, H. (2008). The effects of atropine on changes in the sleep patterns induced by psychological stress in rats. European Journal of Pharmacology, 579(1-3), 153-9.
Cui R, et al. The Effects of Atropine On Changes in the Sleep Patterns Induced By Psychological Stress in Rats. Eur J Pharmacol. 2008 Jan 28;579(1-3):153-9. PubMed PMID: 17961548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of atropine on changes in the sleep patterns induced by psychological stress in rats. AU - Cui,Ranji, AU - Suemaru,Katsuya, AU - Li,Bingjin, AU - Araki,Hiroaki, Y1 - 2007/10/06/ PY - 2007/05/28/received PY - 2007/09/24/revised PY - 2007/09/27/accepted PY - 2007/10/27/pubmed PY - 2008/4/16/medline PY - 2007/10/27/entrez SP - 153 EP - 9 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 579 IS - 1-3 N2 - The present study was designed to investigate the acute effects of psychological stress on the sleep patterns of rats and the potential mechanisms underlying these effects. Psychological stress was induced using a communication box. In a preliminary study, sleep recording was performed for 6 h immediately after 1-h stress in rats. The results showed that psychological stress significantly enhanced the total amount of rapid eye movement (REM) sleep by prolonging the average duration of REM sleep episodes during first 3 h of sleep, whereas the total amount of non-rapid eye movement sleep was not influenced. In a second study, three doses of atropine (3, 10, or 30 nmol) were intracerebroventricularly microinjected into the rats. Total REM sleep was inhibited by the highest dose of atropine during the first 3 h of sleep in the stressed group but not in the control group; the inhibition of total REM sleep was due to a reduction in the average duration of REM sleep episodes. These results suggest that the increase in total REM sleep induced by stress was related to the activation of cholinergic neurons. In addition, plasma corticosterone--an index of hypothalamic-pituitary-adrenal (HPA) axis activity in response to stress--was examined after psychological stress. The concentration of corticosterone did not change significantly. Therefore, the abnormal sleep patterns could not be simply attributed to the HPA axis. These results indicate that the changes in sleep patterns induced by stress were related to cholinergic neurons, but not the HPA axis. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17961548/The_effects_of_atropine_on_changes_in_the_sleep_patterns_induced_by_psychological_stress_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)01063-1 DB - PRIME DP - Unbound Medicine ER -