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Randomized controlled trial comparing superovulation with letrozole versus recombinant follicle-stimulating hormone combined with intrauterine insemination for couples with unexplained infertility who had failed clomiphene citrate stimulation and intrauterine insemination.
Fertil Steril. 2008 Sep; 90(3):678-83.FS

Abstract

OBJECTIVE

To compare the efficacy of letrozole to recombinant FSH for ovarian stimulation combined with IUI in a group of patients that had failed to conceive after clomiphene citrate (CC) and IUI.

DESIGN

Prospective randomized trial with human subjects.

SETTING

University-based fertility center.

PATIENT(S)

Fifty couples with unexplained infertility that failed to conceive after three cycles of CC combined to IUI.

INTERVENTION(S)

Couples were randomized to undergo superovulation either with letrozole or with recombinant FSH combined to IUI.

MAIN OUTCOME MEASURE(S)

Clinical pregnancy per cycle of treatment and clinical pregnancy per couple.

RESULT(S)

Pregnancy rate (PR) per cycle was 8.9% in the letrozole group as compared with 14% in the gonadotropin IUI group. This resulted in a cumulative PR per couple of 24% versus 36% and a take home baby rate of 20% versus 28%. Endometrial thickness was significantly lower in the letrozole group (7.1 +/- 2.3 vs 8.6 +/- 1.8).

CONCLUSION(S)

Ovarian stimulation with letrozole is associated with acceptable PRs compared with gonadotropin with significant less cost, risks, and patient inconvenience.

Authors+Show Affiliations

Aretaieion University Hospital, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17961561

Citation

Gregoriou, Odysseas, et al. "Randomized Controlled Trial Comparing Superovulation With Letrozole Versus Recombinant Follicle-stimulating Hormone Combined With Intrauterine Insemination for Couples With Unexplained Infertility Who Had Failed Clomiphene Citrate Stimulation and Intrauterine Insemination." Fertility and Sterility, vol. 90, no. 3, 2008, pp. 678-83.
Gregoriou O, Vlahos NF, Konidaris S, et al. Randomized controlled trial comparing superovulation with letrozole versus recombinant follicle-stimulating hormone combined with intrauterine insemination for couples with unexplained infertility who had failed clomiphene citrate stimulation and intrauterine insemination. Fertil Steril. 2008;90(3):678-83.
Gregoriou, O., Vlahos, N. F., Konidaris, S., Papadias, K., Botsis, D., & Creatsas, G. K. (2008). Randomized controlled trial comparing superovulation with letrozole versus recombinant follicle-stimulating hormone combined with intrauterine insemination for couples with unexplained infertility who had failed clomiphene citrate stimulation and intrauterine insemination. Fertility and Sterility, 90(3), 678-83.
Gregoriou O, et al. Randomized Controlled Trial Comparing Superovulation With Letrozole Versus Recombinant Follicle-stimulating Hormone Combined With Intrauterine Insemination for Couples With Unexplained Infertility Who Had Failed Clomiphene Citrate Stimulation and Intrauterine Insemination. Fertil Steril. 2008;90(3):678-83. PubMed PMID: 17961561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized controlled trial comparing superovulation with letrozole versus recombinant follicle-stimulating hormone combined with intrauterine insemination for couples with unexplained infertility who had failed clomiphene citrate stimulation and intrauterine insemination. AU - Gregoriou,Odysseas, AU - Vlahos,Nikos F, AU - Konidaris,Socrates, AU - Papadias,Konstantinos, AU - Botsis,Dimitrios, AU - Creatsas,George K, Y1 - 2007/10/25/ PY - 2007/04/03/received PY - 2007/06/22/revised PY - 2007/06/28/accepted PY - 2007/10/27/pubmed PY - 2008/11/13/medline PY - 2007/10/27/entrez SP - 678 EP - 83 JF - Fertility and sterility JO - Fertil. Steril. VL - 90 IS - 3 N2 - OBJECTIVE: To compare the efficacy of letrozole to recombinant FSH for ovarian stimulation combined with IUI in a group of patients that had failed to conceive after clomiphene citrate (CC) and IUI. DESIGN: Prospective randomized trial with human subjects. SETTING: University-based fertility center. PATIENT(S): Fifty couples with unexplained infertility that failed to conceive after three cycles of CC combined to IUI. INTERVENTION(S): Couples were randomized to undergo superovulation either with letrozole or with recombinant FSH combined to IUI. MAIN OUTCOME MEASURE(S): Clinical pregnancy per cycle of treatment and clinical pregnancy per couple. RESULT(S): Pregnancy rate (PR) per cycle was 8.9% in the letrozole group as compared with 14% in the gonadotropin IUI group. This resulted in a cumulative PR per couple of 24% versus 36% and a take home baby rate of 20% versus 28%. Endometrial thickness was significantly lower in the letrozole group (7.1 +/- 2.3 vs 8.6 +/- 1.8). CONCLUSION(S): Ovarian stimulation with letrozole is associated with acceptable PRs compared with gonadotropin with significant less cost, risks, and patient inconvenience. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17961561/Randomized_controlled_trial_comparing_superovulation_with_letrozole_versus_recombinant_follicle_stimulating_hormone_combined_with_intrauterine_insemination_for_couples_with_unexplained_infertility_who_had_failed_clomiphene_citrate_stimulation_and_intrauterine_insemination_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)01541-5 DB - PRIME DP - Unbound Medicine ER -