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Lipoprotein(a) levels are increased in healthy young subjects with parental history of premature myocardial infarction.
Nutr Metab Cardiovasc Dis. 2008 Sep; 18(7):492-6.NM

Abstract

BACKGROUND AND AIM

Most but not all studies in children, adolescents and young adults with a family history of coronary artery disease have reported an increase in lipoprotein(a) (Lp(a)) concentrations. The aim of this study was to assess if healthy children, adolescents and young adults with a parental history of premature myocardial infarction (PHPMI) have increased Lp(a) levels and are at higher risk of elevated (>30 mg/dl) Lp(a) concentrations.

METHODS AND RESULTS

One hundred fifty healthy children, adolescents and young adults with PHPMI (55% males; age 18+/-6.7 years) and 150 age- (+/-1 year) and gender-matched control subjects participated in the study. Concentrations of total plasma cholesterol, low-density lipoprotein (LDL)-cholesterol, high density lipoprotein (HDL)-cholesterol, apolipoprotein (Apo) A-I and B, triglycerides and Lp(a) were determined after fasting for 14 h. Participants with PHPMI had higher concentrations of LDL-cholesterol (107.9+/-31.1 vs. 99.2+/-28.7 mg/dl, p=0.01), Apo B (89.6+/-26.4 vs. 82.8+/-20.2 mg/dl, p=0.011) and Lp(a) (26.7+/-34.0 vs. 19.2+/-23.2 mg/dl, p=0.012) and lower HDL-cholesterol concentrations (47.9+/-11.3 vs. 50.7+/-13.9 mg/dl, p=0.038) than participants without PHPMI. Thirty percent of PHPMI positive subjects had elevated Lp(a) concentrations vs. 16.7% of PHPMI negative subjects (p=0.009; relative risk 2.14; 95% CI 1.23-3.73). In a conditional logistic regression analysis, Lp(a) concentration was significantly and independently associated with PHPMI.

CONCLUSIONS

Healthy young subjects with PHPMI have increased Lp(a) levels, a higher risk for elevated Lp(a) concentrations within an unfavourable lipid profile.

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Authors+Show Affiliations

Gaeta G
Division of Cardiology, A. Cardarelli Hospital, Naples, Italy. giovanni.gaeta@tin.it
Cuomo S
No affiliation info available
Capozzi G
No affiliation info available
Foglia MC
No affiliation info available
Barra S
No affiliation info available
Madrid A
No affiliation info available
Stornaiuolo V
No affiliation info available
Trevisan M
No affiliation info available

MeSH

AdolescentAdultApolipoprotein A-IApolipoproteinsApolipoproteins BBiomarkersCase-Control StudiesChildChild, PreschoolCholesterolCholesterol, HDLCholesterol, LDLFemaleHumansLipoprotein(a)Logistic ModelsMaleMyocardial InfarctionRisk AssessmentRisk FactorsTriglycerides

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17962002

Citation

Gaeta, Giovanni, et al. "Lipoprotein(a) Levels Are Increased in Healthy Young Subjects With Parental History of Premature Myocardial Infarction." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 18, no. 7, 2008, pp. 492-6.
Gaeta G, Cuomo S, Capozzi G, et al. Lipoprotein(a) levels are increased in healthy young subjects with parental history of premature myocardial infarction. Nutr Metab Cardiovasc Dis. 2008;18(7):492-6.
Gaeta, G., Cuomo, S., Capozzi, G., Foglia, M. C., Barra, S., Madrid, A., Stornaiuolo, V., & Trevisan, M. (2008). Lipoprotein(a) levels are increased in healthy young subjects with parental history of premature myocardial infarction. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 18(7), 492-6.
Gaeta G, et al. Lipoprotein(a) Levels Are Increased in Healthy Young Subjects With Parental History of Premature Myocardial Infarction. Nutr Metab Cardiovasc Dis. 2008;18(7):492-6. PubMed PMID: 17962002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipoprotein(a) levels are increased in healthy young subjects with parental history of premature myocardial infarction. AU - Gaeta,Giovanni, AU - Cuomo,Sergio, AU - Capozzi,Giovanbattista, AU - Foglia,Maria C, AU - Barra,Silvia, AU - Madrid,Alfredo, AU - Stornaiuolo,Vincenzo, AU - Trevisan,Maurizio, Y1 - 2007/10/24/ PY - 2006/12/21/received PY - 2007/03/20/revised PY - 2007/03/30/accepted PY - 2007/10/27/pubmed PY - 2008/10/10/medline PY - 2007/10/27/entrez SP - 492 EP - 6 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 18 IS - 7 N2 - BACKGROUND AND AIM: Most but not all studies in children, adolescents and young adults with a family history of coronary artery disease have reported an increase in lipoprotein(a) (Lp(a)) concentrations. The aim of this study was to assess if healthy children, adolescents and young adults with a parental history of premature myocardial infarction (PHPMI) have increased Lp(a) levels and are at higher risk of elevated (>30 mg/dl) Lp(a) concentrations. METHODS AND RESULTS: One hundred fifty healthy children, adolescents and young adults with PHPMI (55% males; age 18+/-6.7 years) and 150 age- (+/-1 year) and gender-matched control subjects participated in the study. Concentrations of total plasma cholesterol, low-density lipoprotein (LDL)-cholesterol, high density lipoprotein (HDL)-cholesterol, apolipoprotein (Apo) A-I and B, triglycerides and Lp(a) were determined after fasting for 14 h. Participants with PHPMI had higher concentrations of LDL-cholesterol (107.9+/-31.1 vs. 99.2+/-28.7 mg/dl, p=0.01), Apo B (89.6+/-26.4 vs. 82.8+/-20.2 mg/dl, p=0.011) and Lp(a) (26.7+/-34.0 vs. 19.2+/-23.2 mg/dl, p=0.012) and lower HDL-cholesterol concentrations (47.9+/-11.3 vs. 50.7+/-13.9 mg/dl, p=0.038) than participants without PHPMI. Thirty percent of PHPMI positive subjects had elevated Lp(a) concentrations vs. 16.7% of PHPMI negative subjects (p=0.009; relative risk 2.14; 95% CI 1.23-3.73). In a conditional logistic regression analysis, Lp(a) concentration was significantly and independently associated with PHPMI. CONCLUSIONS: Healthy young subjects with PHPMI have increased Lp(a) levels, a higher risk for elevated Lp(a) concentrations within an unfavourable lipid profile. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/17962002/Lipoprotein_a__levels_are_increased_in_healthy_young_subjects_with_parental_history_of_premature_myocardial_infarction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(07)00106-8 DB - PRIME DP - Unbound Medicine ER -