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Markers of endothelial dysfunction in children with idiopathic nephrotic syndrome.
Am J Nephrol. 2008; 28(2):197-202.AJ

Abstract

Endothelial function impairment may constitute a link between nephrotic syndrome and atherosclerosis. We assessed changes in plasma thrombomodulin, von Willebrand factor and plasminogen activator inhibitor-1 at different stages of idiopathic nephrotic syndrome in children and correlated them with clinical and biochemical parameters. The study group included 132 nephrotic children (aged 2-18 years) divided into four groups, i.e. in acute phase of the disease with proteinuria, during steroid-induced remission, steroid-free remission, and in long-term, steroid-free remission. Forty-one healthy children served as controls. Plasma thrombomodulin, plasminogen activator inhibitor-1 and von Willebrand factor activity were increased in children with early nephrotic relapse. They systematically decreased in later stages of the disease but the increase in von Willebrand factor persisted in drug-free remission. These disturbances were dependent on the degree of proteinuria and serum albumin concentration. The study revealed that nephrotic children show markers of endothelial dysfunction that are dependent on the disease activity. This leads to the hypothesis that children with severe clinical course of nephrotic syndrome may be at high risk of accelerated atherogenesis.

Authors+Show Affiliations

Department of Nephrology and Dialysis, Polish Mother's Memorial Hospital Research Institute, Łódź, Poland. mtkaczyk@uni.lodz.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17962717

Citation

Tkaczyk, Marcin, et al. "Markers of Endothelial Dysfunction in Children With Idiopathic Nephrotic Syndrome." American Journal of Nephrology, vol. 28, no. 2, 2008, pp. 197-202.
Tkaczyk M, Czupryniak A, Owczarek D, et al. Markers of endothelial dysfunction in children with idiopathic nephrotic syndrome. Am J Nephrol. 2008;28(2):197-202.
Tkaczyk, M., Czupryniak, A., Owczarek, D., Lukamowicz, J., & Nowicki, M. (2008). Markers of endothelial dysfunction in children with idiopathic nephrotic syndrome. American Journal of Nephrology, 28(2), 197-202.
Tkaczyk M, et al. Markers of Endothelial Dysfunction in Children With Idiopathic Nephrotic Syndrome. Am J Nephrol. 2008;28(2):197-202. PubMed PMID: 17962717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Markers of endothelial dysfunction in children with idiopathic nephrotic syndrome. AU - Tkaczyk,Marcin, AU - Czupryniak,Aneta, AU - Owczarek,Danuta, AU - Lukamowicz,Jolanta, AU - Nowicki,Michał, Y1 - 2007/10/24/ PY - 2007/07/10/received PY - 2007/08/27/accepted PY - 2007/10/27/pubmed PY - 2008/5/23/medline PY - 2007/10/27/entrez SP - 197 EP - 202 JF - American journal of nephrology JO - Am. J. Nephrol. VL - 28 IS - 2 N2 - Endothelial function impairment may constitute a link between nephrotic syndrome and atherosclerosis. We assessed changes in plasma thrombomodulin, von Willebrand factor and plasminogen activator inhibitor-1 at different stages of idiopathic nephrotic syndrome in children and correlated them with clinical and biochemical parameters. The study group included 132 nephrotic children (aged 2-18 years) divided into four groups, i.e. in acute phase of the disease with proteinuria, during steroid-induced remission, steroid-free remission, and in long-term, steroid-free remission. Forty-one healthy children served as controls. Plasma thrombomodulin, plasminogen activator inhibitor-1 and von Willebrand factor activity were increased in children with early nephrotic relapse. They systematically decreased in later stages of the disease but the increase in von Willebrand factor persisted in drug-free remission. These disturbances were dependent on the degree of proteinuria and serum albumin concentration. The study revealed that nephrotic children show markers of endothelial dysfunction that are dependent on the disease activity. This leads to the hypothesis that children with severe clinical course of nephrotic syndrome may be at high risk of accelerated atherogenesis. SN - 1421-9670 UR - https://www.unboundmedicine.com/medline/citation/17962717/Markers_of_endothelial_dysfunction_in_children_with_idiopathic_nephrotic_syndrome_ L2 - https://www.karger.com?DOI=10.1159/000110088 DB - PRIME DP - Unbound Medicine ER -