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Biotransformation of green tea polyphenols and the biological activities of those metabolites.
Mol Pharm. 2007 Nov-Dec; 4(6):819-25.MP

Abstract

Green tea (Camellia sinensis, Theaceae) and its major polyphenol constituents, the catechins, have been reported to have many health benefits including the prevention of cancer and heart disease. Many mechanisms of action have been proposed based on in vitro models; however, the importance of most of these mechanisms remains to be determined in vivo. The bioavailability and biotransformation of tea catechins play a key role in determining the importance of various mechanisms in vivo. Likewise, the biological activity and bioavailability of tea catechin metabolites, an understudied area, are important in understanding the potential beneficial effects of tea. In this article, we review the data available on the biotransformation of the tea catechins and the limited data set available on the biological activities of the catechin metabolites. Careful interpretation of available data, carefully designed animal experiments, and integration of bioavailability and biological activity data are needed if the disease preventive activity of tea is to be understood. We hope this article will spark research efforts on some of the important questions regarding tea polyphenol bioavailability, biotransformation, and the biological activities of tea catechin metabolites.

Authors+Show Affiliations

Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA. joshua_lambert@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17963356

Citation

Lambert, Joshua D., et al. "Biotransformation of Green Tea Polyphenols and the Biological Activities of Those Metabolites." Molecular Pharmaceutics, vol. 4, no. 6, 2007, pp. 819-25.
Lambert JD, Sang S, Yang CS. Biotransformation of green tea polyphenols and the biological activities of those metabolites. Mol Pharm. 2007;4(6):819-25.
Lambert, J. D., Sang, S., & Yang, C. S. (2007). Biotransformation of green tea polyphenols and the biological activities of those metabolites. Molecular Pharmaceutics, 4(6), 819-25.
Lambert JD, Sang S, Yang CS. Biotransformation of Green Tea Polyphenols and the Biological Activities of Those Metabolites. Mol Pharm. 2007 Nov-Dec;4(6):819-25. PubMed PMID: 17963356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biotransformation of green tea polyphenols and the biological activities of those metabolites. AU - Lambert,Joshua D, AU - Sang,Shengmin, AU - Yang,Chung S, Y1 - 2007/10/27/ PY - 2007/10/30/pubmed PY - 2008/2/13/medline PY - 2007/10/30/entrez SP - 819 EP - 25 JF - Molecular pharmaceutics JO - Mol Pharm VL - 4 IS - 6 N2 - Green tea (Camellia sinensis, Theaceae) and its major polyphenol constituents, the catechins, have been reported to have many health benefits including the prevention of cancer and heart disease. Many mechanisms of action have been proposed based on in vitro models; however, the importance of most of these mechanisms remains to be determined in vivo. The bioavailability and biotransformation of tea catechins play a key role in determining the importance of various mechanisms in vivo. Likewise, the biological activity and bioavailability of tea catechin metabolites, an understudied area, are important in understanding the potential beneficial effects of tea. In this article, we review the data available on the biotransformation of the tea catechins and the limited data set available on the biological activities of the catechin metabolites. Careful interpretation of available data, carefully designed animal experiments, and integration of bioavailability and biological activity data are needed if the disease preventive activity of tea is to be understood. We hope this article will spark research efforts on some of the important questions regarding tea polyphenol bioavailability, biotransformation, and the biological activities of tea catechin metabolites. SN - 1543-8384 UR - https://www.unboundmedicine.com/medline/citation/17963356/Biotransformation_of_green_tea_polyphenols_and_the_biological_activities_of_those_metabolites_ L2 - https://doi.org/10.1021/mp700075m DB - PRIME DP - Unbound Medicine ER -