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Antimutagenic potential of the Thai herb, Mucuna collettii Lace.
J Ethnopharmacol. 2008 Jan 04; 115(1):96-103.JE

Abstract

Mucuna collettii Lace is a Thai herb with a long record of consumption among mature Thai males for the promotion of sexual potency. The mutagenic and antimutagenic potentials of Mucuna collettii extract were carried out by using the Ames test pre-incubation method in the presence and absence of S9 mixture. Salmonella typhimurium strains TA 98 and TA 100 were applied as the tester strains. Prior to mutagenic and antimutagenic tests, the survival of the tester strains was performed by treating with the plant extract. Results showed Mucuna collettii extract exhibited strong cytotoxic effects in a dose-dependent manner. Toxicity of the plant was confirmed in mice in which negative adverse effect was found in kidney, uterus, ovary, and testis. Mucuna collettii extract in the presence and absence of S9 mixture was negative for mutagenic Ames test. Mucuna collettii extract in the presence and absence of S9 mixture was positive for antimutagenic Ames test towards either one or both of the tested mutagens: 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide (AF-2) and benzo(a)pyrene. The antimutagenic activity of the plant extract was confirmed in rec-assays. Micronucleus test demonstrated that Mucuna collettii extract at high dose and a long incubation time could induce micronucleus formation in tested animals, but less than the response of the positive control. The overall mutagenic and antimutagenic assays are further evidences for the antimutagenic potential of Mucuna collettii.

Authors+Show Affiliations

Department of Biology, Faculty of Science, Chulalongkorn University, Phyathai Road, Patumwan, Bangkok 10330, Thailand. cwichai@sc.chula.ac.thNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17964098

Citation

Cherdshewasart, Wichai, et al. "Antimutagenic Potential of the Thai Herb, Mucuna Collettii Lace." Journal of Ethnopharmacology, vol. 115, no. 1, 2008, pp. 96-103.
Cherdshewasart W, Sutjit W, Pulcharoen K, et al. Antimutagenic potential of the Thai herb, Mucuna collettii Lace. J Ethnopharmacol. 2008;115(1):96-103.
Cherdshewasart, W., Sutjit, W., Pulcharoen, K., Panriansaen, R., & Chulasiri, M. (2008). Antimutagenic potential of the Thai herb, Mucuna collettii Lace. Journal of Ethnopharmacology, 115(1), 96-103.
Cherdshewasart W, et al. Antimutagenic Potential of the Thai Herb, Mucuna Collettii Lace. J Ethnopharmacol. 2008 Jan 4;115(1):96-103. PubMed PMID: 17964098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimutagenic potential of the Thai herb, Mucuna collettii Lace. AU - Cherdshewasart,Wichai, AU - Sutjit,Wandee, AU - Pulcharoen,Kade, AU - Panriansaen,Rattana, AU - Chulasiri,Malyn, Y1 - 2007/09/18/ PY - 2007/02/22/received PY - 2007/08/24/revised PY - 2007/09/12/accepted PY - 2007/10/30/pubmed PY - 2008/4/23/medline PY - 2007/10/30/entrez SP - 96 EP - 103 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 115 IS - 1 N2 - Mucuna collettii Lace is a Thai herb with a long record of consumption among mature Thai males for the promotion of sexual potency. The mutagenic and antimutagenic potentials of Mucuna collettii extract were carried out by using the Ames test pre-incubation method in the presence and absence of S9 mixture. Salmonella typhimurium strains TA 98 and TA 100 were applied as the tester strains. Prior to mutagenic and antimutagenic tests, the survival of the tester strains was performed by treating with the plant extract. Results showed Mucuna collettii extract exhibited strong cytotoxic effects in a dose-dependent manner. Toxicity of the plant was confirmed in mice in which negative adverse effect was found in kidney, uterus, ovary, and testis. Mucuna collettii extract in the presence and absence of S9 mixture was negative for mutagenic Ames test. Mucuna collettii extract in the presence and absence of S9 mixture was positive for antimutagenic Ames test towards either one or both of the tested mutagens: 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide (AF-2) and benzo(a)pyrene. The antimutagenic activity of the plant extract was confirmed in rec-assays. Micronucleus test demonstrated that Mucuna collettii extract at high dose and a long incubation time could induce micronucleus formation in tested animals, but less than the response of the positive control. The overall mutagenic and antimutagenic assays are further evidences for the antimutagenic potential of Mucuna collettii. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17964098/Antimutagenic_potential_of_the_Thai_herb_Mucuna_collettii_Lace_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00487-4 DB - PRIME DP - Unbound Medicine ER -