Tags

Type your tag names separated by a space and hit enter

Endoscopic tri-modal imaging for detection of early neoplasia in Barrett's oesophagus: a multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system.
Gut. 2008 Feb; 57(2):167-72.Gut

Abstract

OBJECTIVE

To investigate the diagnostic potential of endoscopic tri-modal imaging and the relative contribution of each imaging modality (i.e. high-resolution endoscopy (HRE), autofluorescence imaging (AFI) and narrow-band imaging (NBI)) for the detection of early neoplasia in Barrett's oesophagus.

DESIGN

Prospective multi-centre study.

SETTING

Tertiary referral centres.

PATIENTS

84 Patients with Barrett's oesophagus.

INTERVENTIONS

The Barrett's oesophagus was inspected with HRE followed by AFI. All lesions detected with HRE and/or AFI were subsequently inspected in detail by NBI for the presence of abnormal mucosal and/or microvascular patterns. Biopsies were obtained from all suspicious lesions for blinded histopathological assessment followed by random biopsies.

MAIN OUTCOME MEASURES

(1) Number of patients with early neoplasia diagnosed by HRE and AFI; (2) number of lesions with early neoplasia detected with HRE and AFI; and (3) reduction of false positive AFI findings after NBI.

RESULTS

Per patient analysis: AFI identified all 16 patients with early neoplasia identified with HRE and detected an additional 11 patients with early neoplasia that were not identified with HRE. In three patients no abnormalities were seen but random biopsies revealed HGIN. After HRE inspection, AFI detected an additional 102 lesions; 19 contained HGIN/EC (false positive rate of AFI after HRE: 81%). Detailed inspection with NBI reduced this false positive rate to 26%.

CONCLUSIONS

In this international multi-centre study, the addition of AFI to HRE increased the detection of both the number of patients and the number of lesions with early neoplasia in patients with Barrett's oesophagus. The false positive rate of AFI was reduced after detailed inspection with NBI.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Academic Medical Centre, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17965067

Citation

Curvers, W L., et al. "Endoscopic Tri-modal Imaging for Detection of Early Neoplasia in Barrett's Oesophagus: a Multi-centre Feasibility Study Using High-resolution Endoscopy, Autofluorescence Imaging and Narrow Band Imaging Incorporated in One Endoscopy System." Gut, vol. 57, no. 2, 2008, pp. 167-72.
Curvers WL, Singh R, Song LM, et al. Endoscopic tri-modal imaging for detection of early neoplasia in Barrett's oesophagus: a multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system. Gut. 2008;57(2):167-72.
Curvers, W. L., Singh, R., Song, L. M., Wolfsen, H. C., Ragunath, K., Wang, K., Wallace, M. B., Fockens, P., & Bergman, J. J. (2008). Endoscopic tri-modal imaging for detection of early neoplasia in Barrett's oesophagus: a multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system. Gut, 57(2), 167-72.
Curvers WL, et al. Endoscopic Tri-modal Imaging for Detection of Early Neoplasia in Barrett's Oesophagus: a Multi-centre Feasibility Study Using High-resolution Endoscopy, Autofluorescence Imaging and Narrow Band Imaging Incorporated in One Endoscopy System. Gut. 2008;57(2):167-72. PubMed PMID: 17965067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endoscopic tri-modal imaging for detection of early neoplasia in Barrett's oesophagus: a multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system. AU - Curvers,W L, AU - Singh,R, AU - Song,L-M Wong-Kee, AU - Wolfsen,H C, AU - Ragunath,K, AU - Wang,K, AU - Wallace,M B, AU - Fockens,P, AU - Bergman,J J G H M, Y1 - 2007/10/26/ PY - 2007/10/30/pubmed PY - 2008/2/13/medline PY - 2007/10/30/entrez SP - 167 EP - 72 JF - Gut JO - Gut VL - 57 IS - 2 N2 - OBJECTIVE: To investigate the diagnostic potential of endoscopic tri-modal imaging and the relative contribution of each imaging modality (i.e. high-resolution endoscopy (HRE), autofluorescence imaging (AFI) and narrow-band imaging (NBI)) for the detection of early neoplasia in Barrett's oesophagus. DESIGN: Prospective multi-centre study. SETTING: Tertiary referral centres. PATIENTS: 84 Patients with Barrett's oesophagus. INTERVENTIONS: The Barrett's oesophagus was inspected with HRE followed by AFI. All lesions detected with HRE and/or AFI were subsequently inspected in detail by NBI for the presence of abnormal mucosal and/or microvascular patterns. Biopsies were obtained from all suspicious lesions for blinded histopathological assessment followed by random biopsies. MAIN OUTCOME MEASURES: (1) Number of patients with early neoplasia diagnosed by HRE and AFI; (2) number of lesions with early neoplasia detected with HRE and AFI; and (3) reduction of false positive AFI findings after NBI. RESULTS: Per patient analysis: AFI identified all 16 patients with early neoplasia identified with HRE and detected an additional 11 patients with early neoplasia that were not identified with HRE. In three patients no abnormalities were seen but random biopsies revealed HGIN. After HRE inspection, AFI detected an additional 102 lesions; 19 contained HGIN/EC (false positive rate of AFI after HRE: 81%). Detailed inspection with NBI reduced this false positive rate to 26%. CONCLUSIONS: In this international multi-centre study, the addition of AFI to HRE increased the detection of both the number of patients and the number of lesions with early neoplasia in patients with Barrett's oesophagus. The false positive rate of AFI was reduced after detailed inspection with NBI. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/17965067/Endoscopic_tri_modal_imaging_for_detection_of_early_neoplasia_in_Barrett's_oesophagus:_a_multi_centre_feasibility_study_using_high_resolution_endoscopy_autofluorescence_imaging_and_narrow_band_imaging_incorporated_in_one_endoscopy_system_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=17965067 DB - PRIME DP - Unbound Medicine ER -