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Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovary syndrome. A prospective comparative study.
Saudi Med J. 2007 Nov; 28(11):1694-9.SM

Abstract

OBJECTIVE

To compare the clinical results and reproductive outcome in obese women with polycystic ovary syndrome (PCOS) following dietary intervention or treatment with metformin.

METHODS

Forty-six patients with PCOS were studied prospectively in Prince Rashed Hospital, Irbid, Jordan, between January 2003 and April 2005. The women were randomly divided into 2 groups: Group 1 (n=24) was prescribed with 1200-1400 kcal/day diet (25% proteins, 25% fat, and 50% carbohydrates plus 25-30 gm of fiber per week). Group 2 (n=22) was assigned to take 850 mg of metformin twice in a continuous manner. Both treatments continued for 6 months. Clinical and biochemical data, before and after both treatments along with the reproductive outcome were compared between the 2 groups.

RESULTS

There were no significant differences between the 2 groups in terms of age, body mass index (BMI) and duration of infertility. Both groups had a significant improvement after treatment in the menstrual cyclicity (66.7% and 68.2% versus 12.5% and 18.2%) and significant reduction in BMI (mean of 27.4 and 27.8 versus 32.2 and 31.9), luteinizing hormone levels (7.9+/-1.7 and 6.9+/-1.8 versus 11.8+/-2.2 and 11.5+/-1.8), and androgen (testosterone, androstenedione, dehydroepiandrosterone sulfate) concentration. The clinical, biochemical, and reproductive outcome including menstrual cycle pattern, ovulation, and pregnancy rates were similar in both groups after treatment.

CONCLUSION

Amelioration of hyperinsulinemia and hyperandrogenemia with dietary intervention or metformin treatment improves significantly the clinical features and reproductive function in overweight PCOS women.

Authors+Show Affiliations

Department of Obstetrics & Gynecology, Royal Medical Services, Irbid, Aidoun, PO Box 97, Jordan. hqublan@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17965792

Citation

Qublan, Hussein S., et al. "Dietary Intervention Versus Metformin to Improve the Reproductive Outcome in Women With Polycystic Ovary Syndrome. a Prospective Comparative Study." Saudi Medical Journal, vol. 28, no. 11, 2007, pp. 1694-9.
Qublan HS, Yannakoula EK, Al-Qudah MA, et al. Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovary syndrome. A prospective comparative study. Saudi Med J. 2007;28(11):1694-9.
Qublan, H. S., Yannakoula, E. K., Al-Qudah, M. A., & El-Uri, F. I. (2007). Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovary syndrome. A prospective comparative study. Saudi Medical Journal, 28(11), 1694-9.
Qublan HS, et al. Dietary Intervention Versus Metformin to Improve the Reproductive Outcome in Women With Polycystic Ovary Syndrome. a Prospective Comparative Study. Saudi Med J. 2007;28(11):1694-9. PubMed PMID: 17965792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovary syndrome. A prospective comparative study. AU - Qublan,Hussein S, AU - Yannakoula,Eleni K, AU - Al-Qudah,Mohamad A, AU - El-Uri,Fahmi I, PY - 2007/10/30/pubmed PY - 2008/2/22/medline PY - 2007/10/30/entrez SP - 1694 EP - 9 JF - Saudi medical journal JO - Saudi Med J VL - 28 IS - 11 N2 - OBJECTIVE: To compare the clinical results and reproductive outcome in obese women with polycystic ovary syndrome (PCOS) following dietary intervention or treatment with metformin. METHODS: Forty-six patients with PCOS were studied prospectively in Prince Rashed Hospital, Irbid, Jordan, between January 2003 and April 2005. The women were randomly divided into 2 groups: Group 1 (n=24) was prescribed with 1200-1400 kcal/day diet (25% proteins, 25% fat, and 50% carbohydrates plus 25-30 gm of fiber per week). Group 2 (n=22) was assigned to take 850 mg of metformin twice in a continuous manner. Both treatments continued for 6 months. Clinical and biochemical data, before and after both treatments along with the reproductive outcome were compared between the 2 groups. RESULTS: There were no significant differences between the 2 groups in terms of age, body mass index (BMI) and duration of infertility. Both groups had a significant improvement after treatment in the menstrual cyclicity (66.7% and 68.2% versus 12.5% and 18.2%) and significant reduction in BMI (mean of 27.4 and 27.8 versus 32.2 and 31.9), luteinizing hormone levels (7.9+/-1.7 and 6.9+/-1.8 versus 11.8+/-2.2 and 11.5+/-1.8), and androgen (testosterone, androstenedione, dehydroepiandrosterone sulfate) concentration. The clinical, biochemical, and reproductive outcome including menstrual cycle pattern, ovulation, and pregnancy rates were similar in both groups after treatment. CONCLUSION: Amelioration of hyperinsulinemia and hyperandrogenemia with dietary intervention or metformin treatment improves significantly the clinical features and reproductive function in overweight PCOS women. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/17965792/Dietary_intervention_versus_metformin_to_improve_the_reproductive_outcome_in_women_with_polycystic_ovary_syndrome__A_prospective_comparative_study_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -