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A case of non-SIADH-induced hyponatremia in depression after treatment with reboxetine.
World J Biol Psychiatry 2009; 10(4 Pt 2):609-11WJ

Abstract

Hyponatremia is a well-known side effect of antidepressant treatment with serotonin reuptake inhibitors (SSRI) or combined serotonin and noradrenaline reuptake inhibitors (SNRI), and is linked to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in most cases. In contrast, only very few data are available on hyponatremia following treatment with selective noradrenaline reuptake inhibitors (NaRI). In this report, we describe the case of a patient who developed severe hyponatremia after treatment with reboxetine. However, extensive laboratory testing did not reveal inappropriate secretion of ADH, suggesting that SIADH did not account for hyponatremia in our case. Proposing further examination of the underlying pathomechanism of hyponatremia as a side effect of NaRIs, we discuss the importance of careful monitoring of serum sodium levels in patients treated with NaRIs.

Authors+Show Affiliations

University of Muenster, Department of Psychiatry, Muenster, Germany. katja.koelkebeck@ukmuenster.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17965988

Citation

Koelkebeck, Katja, et al. "A Case of non-SIADH-induced Hyponatremia in Depression After Treatment With Reboxetine." The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry, vol. 10, no. 4 Pt 2, 2009, pp. 609-11.
Koelkebeck K, Domschke K, Zwanzger P, et al. A case of non-SIADH-induced hyponatremia in depression after treatment with reboxetine. World J Biol Psychiatry. 2009;10(4 Pt 2):609-11.
Koelkebeck, K., Domschke, K., Zwanzger, P., Hetzel, G., Lang, D., & Arolt, V. (2009). A case of non-SIADH-induced hyponatremia in depression after treatment with reboxetine. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry, 10(4 Pt 2), pp. 609-11.
Koelkebeck K, et al. A Case of non-SIADH-induced Hyponatremia in Depression After Treatment With Reboxetine. World J Biol Psychiatry. 2009;10(4 Pt 2):609-11. PubMed PMID: 17965988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of non-SIADH-induced hyponatremia in depression after treatment with reboxetine. AU - Koelkebeck,Katja, AU - Domschke,Katharina, AU - Zwanzger,Peter, AU - Hetzel,Guenter, AU - Lang,Detlef, AU - Arolt,Volker, PY - 2007/10/30/pubmed PY - 2010/3/2/medline PY - 2007/10/30/entrez SP - 609 EP - 11 JF - The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry JO - World J. Biol. Psychiatry VL - 10 IS - 4 Pt 2 N2 - Hyponatremia is a well-known side effect of antidepressant treatment with serotonin reuptake inhibitors (SSRI) or combined serotonin and noradrenaline reuptake inhibitors (SNRI), and is linked to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in most cases. In contrast, only very few data are available on hyponatremia following treatment with selective noradrenaline reuptake inhibitors (NaRI). In this report, we describe the case of a patient who developed severe hyponatremia after treatment with reboxetine. However, extensive laboratory testing did not reveal inappropriate secretion of ADH, suggesting that SIADH did not account for hyponatremia in our case. Proposing further examination of the underlying pathomechanism of hyponatremia as a side effect of NaRIs, we discuss the importance of careful monitoring of serum sodium levels in patients treated with NaRIs. SN - 1814-1412 UR - https://www.unboundmedicine.com/medline/citation/17965988/A_case_of_non_SIADH_induced_hyponatremia_in_depression_after_treatment_with_reboxetine_ L2 - http://www.tandfonline.com/doi/full/10.1080/15622970701687311 DB - PRIME DP - Unbound Medicine ER -