Tags

Type your tag names separated by a space and hit enter

[Anti-tumor constituents from Paris polyphylla var. yunnanensis].
Zhongguo Zhong Yao Za Zhi. 2007 Jul; 32(14):1425-8.ZZ

Abstract

OBJECTIVE

To study the anti-tumor active constituents from the rhizome of Paris polyphylla var. yunnanensis.

METHOD

The compounds were isolated by column chromatography with silica gel, and purified by Sephadex LH-20 columu chromafography and reverse-phase preparative, HPLC. The structures were identified by spectroscopic methods. The anti-tumor experiment in vitro, the MTT, was used to screen constituents of P. polyphalla var. yunnanensis.

RESULT

Six compounds were obtained and their structures were identified as diosgenin-3-O-alpha-L-arabinofuranosyl (1-->4) -beta-D-glycopyranoside (1), pennogenin-3-O-alpha-L-arabino-furanosyl (1-->4)-beta-D-glycopyranoside (2), isorhamn etin-3-O-beta-D-glycopyranoside (3), ethyl-alpha-D-fructofuranoside (4), pennogenin-3-O-alpha-L-rhamnopyranosyl (1-->4)-[alpha-L-rhamnopyranosyl (1-->2)]-beta-D-glycopyranoside (5) and pennogenin-3-O-alpha-L-rhamnopyranosyl (1-->4)-alpha-L-rhamnopyranosyl (1-->4)-[alpha-L-rhamnopyranosyl (1-->2)]-beta-D-glycopyranoside (6).

CONCLUSION

Compounds 1-4 were isolated from this plant for the first time, compounds 3 and 4 was firstly isolated from genus Paris, compound 5 was firstly isolated from the rhizome of this plant. The pharmacological results showed that compounds 1-3, 5 and 6 showed certain inhibition, especially, the activities of compound 5 and 6 were the most significant.

Authors+Show Affiliations

College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17966357

Citation

Wang, Yu, et al. "[Anti-tumor Constituents From Paris Polyphylla Var. Yunnanensis]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 32, no. 14, 2007, pp. 1425-8.
Wang Y, Zhang YJ, Gao WY, et al. [Anti-tumor constituents from Paris polyphylla var. yunnanensis]. Zhongguo Zhong Yao Za Zhi. 2007;32(14):1425-8.
Wang, Y., Zhang, Y. J., Gao, W. Y., & Yan, L. L. (2007). [Anti-tumor constituents from Paris polyphylla var. yunnanensis]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 32(14), 1425-8.
Wang Y, et al. [Anti-tumor Constituents From Paris Polyphylla Var. Yunnanensis]. Zhongguo Zhong Yao Za Zhi. 2007;32(14):1425-8. PubMed PMID: 17966357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Anti-tumor constituents from Paris polyphylla var. yunnanensis]. AU - Wang,Yu, AU - Zhang,Yan-jun, AU - Gao,Wen-yuan, AU - Yan,Lu-lu, PY - 2007/10/31/pubmed PY - 2008/1/8/medline PY - 2007/10/31/entrez SP - 1425 EP - 8 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 32 IS - 14 N2 - OBJECTIVE: To study the anti-tumor active constituents from the rhizome of Paris polyphylla var. yunnanensis. METHOD: The compounds were isolated by column chromatography with silica gel, and purified by Sephadex LH-20 columu chromafography and reverse-phase preparative, HPLC. The structures were identified by spectroscopic methods. The anti-tumor experiment in vitro, the MTT, was used to screen constituents of P. polyphalla var. yunnanensis. RESULT: Six compounds were obtained and their structures were identified as diosgenin-3-O-alpha-L-arabinofuranosyl (1-->4) -beta-D-glycopyranoside (1), pennogenin-3-O-alpha-L-arabino-furanosyl (1-->4)-beta-D-glycopyranoside (2), isorhamn etin-3-O-beta-D-glycopyranoside (3), ethyl-alpha-D-fructofuranoside (4), pennogenin-3-O-alpha-L-rhamnopyranosyl (1-->4)-[alpha-L-rhamnopyranosyl (1-->2)]-beta-D-glycopyranoside (5) and pennogenin-3-O-alpha-L-rhamnopyranosyl (1-->4)-alpha-L-rhamnopyranosyl (1-->4)-[alpha-L-rhamnopyranosyl (1-->2)]-beta-D-glycopyranoside (6). CONCLUSION: Compounds 1-4 were isolated from this plant for the first time, compounds 3 and 4 was firstly isolated from genus Paris, compound 5 was firstly isolated from the rhizome of this plant. The pharmacological results showed that compounds 1-3, 5 and 6 showed certain inhibition, especially, the activities of compound 5 and 6 were the most significant. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/17966357/[Anti_tumor_constituents_from_Paris_polyphylla_var__yunnanensis]_ DB - PRIME DP - Unbound Medicine ER -