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Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat.

Abstract

The definitive anxiolytic effects of Passiflora incarnata are unknown. We studied the potential anxiolytic effects of chrysin, a Passiflora extract, and the purported modulation of the benzodiazepine receptor on the GABA(A) receptor in laboratory rats. We hypothesized that chrysin decreases anxiety via interaction with the GABA(A) receptor in laboratory rats as measured by elevated plus-maze (EPM), corticosterone, and catecholamine assays. We randomized 44 male Sprague-Dawley rats in a double-blind, placebo-controlled, between-subjects experimental design. Each animal received an intraperitoneal injection of (1) vehicle (DMSO 4%), (2) chrysin, 2 mg/kg, (3) midazolam, 1.5 mg/kg, or (4) flumazenil, 3 mg/kg and chrysin, 2 mg/kg. The EPM was used to evaluate the behavioral component of anxiolysis, and catecholamine and corticosterone assays were examined to measure the neurohormonal effects of anxiety. No statistical difference was found among groups in catecholamine and corticosterone levels. Midazolam significantly decreased anxiety compared with control and flumazenil plus chrysin groups (P <.05); there was no significant difference compared with the chrysin group. These data suggest that chrysin may have anxiolytic properties similar to midazolam but to a lesser magnitude at the 2 mg/kg dose used in this study.

Authors+Show Affiliations

,

US Army Graduate Program in Anesthesia Nursing, Dwight David Eisenhower Army Medical Center, Augusta, Georgia, USA.

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Source

AANA journal 75:5 2007 Oct pg 333-7

MeSH

Analysis of Variance
Animals
Anti-Anxiety Agents
Anxiety
Behavior, Animal
Catecholamines
Corticosterone
Dimethyl Sulfoxide
Disease Models, Animal
Double-Blind Method
Drug Evaluation, Preclinical
Flavonoids
Flumazenil
Male
Maze Learning
Midazolam
Passiflora
Phytotherapy
Plant Extracts
Random Allocation
Rats
Rats, Sprague-Dawley
Receptors, GABA-A

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17966676

Citation

Brown, Eric 'Walter', et al. "Evaluation of the Anxiolytic Effects of Chrysin, a Passiflora Incarnata Extract, in the Laboratory Rat." AANA Journal, vol. 75, no. 5, 2007, pp. 333-7.
Brown E', Hurd NS, McCall S, et al. Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. AANA J. 2007;75(5):333-7.
Brown, E. '., Hurd, N. S., McCall, S., & Ceremuga, T. E. (2007). Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. AANA Journal, 75(5), pp. 333-7.
Brown E', et al. Evaluation of the Anxiolytic Effects of Chrysin, a Passiflora Incarnata Extract, in the Laboratory Rat. AANA J. 2007;75(5):333-7. PubMed PMID: 17966676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. AU - Brown,Eric 'Walter', AU - Hurd,Neil S, AU - McCall,Suzanne, AU - Ceremuga,Thomas E, PY - 2007/10/31/pubmed PY - 2007/12/7/medline PY - 2007/10/31/entrez SP - 333 EP - 7 JF - AANA journal JO - AANA J VL - 75 IS - 5 N2 - The definitive anxiolytic effects of Passiflora incarnata are unknown. We studied the potential anxiolytic effects of chrysin, a Passiflora extract, and the purported modulation of the benzodiazepine receptor on the GABA(A) receptor in laboratory rats. We hypothesized that chrysin decreases anxiety via interaction with the GABA(A) receptor in laboratory rats as measured by elevated plus-maze (EPM), corticosterone, and catecholamine assays. We randomized 44 male Sprague-Dawley rats in a double-blind, placebo-controlled, between-subjects experimental design. Each animal received an intraperitoneal injection of (1) vehicle (DMSO 4%), (2) chrysin, 2 mg/kg, (3) midazolam, 1.5 mg/kg, or (4) flumazenil, 3 mg/kg and chrysin, 2 mg/kg. The EPM was used to evaluate the behavioral component of anxiolysis, and catecholamine and corticosterone assays were examined to measure the neurohormonal effects of anxiety. No statistical difference was found among groups in catecholamine and corticosterone levels. Midazolam significantly decreased anxiety compared with control and flumazenil plus chrysin groups (P <.05); there was no significant difference compared with the chrysin group. These data suggest that chrysin may have anxiolytic properties similar to midazolam but to a lesser magnitude at the 2 mg/kg dose used in this study. SN - 0094-6354 UR - https://www.unboundmedicine.com/medline/citation/17966676/Evaluation_of_the_anxiolytic_effects_of_chrysin_a_Passiflora_incarnata_extract_in_the_laboratory_rat_ L2 - https://medlineplus.gov/anxiety.html DB - PRIME DP - Unbound Medicine ER -