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[The relationship between aldehyde dehydrogenase-2 gene polymorphisms and efficacy of nitroglycerin].
Zhonghua Nei Ke Za Zhi. 2007 Aug; 46(8):629-32.ZN

Abstract

OBJECTIVE

To investigate the association among aldehyde dehydrogenase-2 (ALDH2) gene polymorphisms, alcohol flushing and efficacy of nitroglycerin (GTN) in patients with coronary heart disease.

METHODS

One hundred and forty two patients with coronary heart disease, who were confirmed by coronary angiography and consistent with the criteria of selection were enrolled in this study. The patients were divided into two groups according to flushing or not after drinking wine: non-flushing group (n = 88) and flushing group (n = 54). The genotypes of ALDH2 were determined with polymerase chain reaction and direct sequencing. The efficacy of nitroglycerin on angina pectoris attacks for all the patients were obtained by observation and inquiry. Basal clinical data and nitroglycerin efficacy between the two groups were compared.

RESULTS

The rate of efficacious response to GTN and ALDH2*1 genotype in non-flushing group were significantly higher than those in the flushing group (89.8% vs 37.0%, P < 0.01; 93.2% vs 44.4%, P < 0.01). The number of patients with angina pectoris attacks ameliorated by GTN in 5 minutes in the non-flushing group were remarkably higher than that in the flushing group (67.1% vs 20.4%, P < 0.01). The rate of efficacious response to GTN was significantly higher in the patients with ALDH2*1 genotype than the patients with ALDH2*2 genotype (81.1% vs 36.1%, P < 0.01) and the efficacious response to GTN in 5 minutes was higher in the patients with ALDH2*1 genotype than those with ALDH2*2 genotype (57.5% vs 11.1%, P < 0.01).

CONCLUSIONS

There is relationship among ALDH2 gene polymorphisms, alcohol flushing and efficacy of nitroglycerin. The rate of efficacious response to GTN is significantly higher in non-flushing patients; this may be explained by the effect of gene polymorphisms.

Authors+Show Affiliations

Department of Emergency, Qilu Hospital of Shandong University, Jinan 250012, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

17967228

Citation

Zhang, He, et al. "[The Relationship Between Aldehyde Dehydrogenase-2 Gene Polymorphisms and Efficacy of Nitroglycerin]." Zhonghua Nei Ke Za Zhi, vol. 46, no. 8, 2007, pp. 629-32.
Zhang H, Chen YG, Xu F, et al. [The relationship between aldehyde dehydrogenase-2 gene polymorphisms and efficacy of nitroglycerin]. Zhonghua Nei Ke Za Zhi. 2007;46(8):629-32.
Zhang, H., Chen, Y. G., Xu, F., Xue, L., Jiang, C. X., & Zhang, Y. (2007). [The relationship between aldehyde dehydrogenase-2 gene polymorphisms and efficacy of nitroglycerin]. Zhonghua Nei Ke Za Zhi, 46(8), 629-32.
Zhang H, et al. [The Relationship Between Aldehyde Dehydrogenase-2 Gene Polymorphisms and Efficacy of Nitroglycerin]. Zhonghua Nei Ke Za Zhi. 2007;46(8):629-32. PubMed PMID: 17967228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The relationship between aldehyde dehydrogenase-2 gene polymorphisms and efficacy of nitroglycerin]. AU - Zhang,He, AU - Chen,Yu-guo, AU - Xu,Feng, AU - Xue,Li, AU - Jiang,Chun-xiao, AU - Zhang,Yun, PY - 2007/10/31/pubmed PY - 2008/7/12/medline PY - 2007/10/31/entrez SP - 629 EP - 32 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 46 IS - 8 N2 - OBJECTIVE: To investigate the association among aldehyde dehydrogenase-2 (ALDH2) gene polymorphisms, alcohol flushing and efficacy of nitroglycerin (GTN) in patients with coronary heart disease. METHODS: One hundred and forty two patients with coronary heart disease, who were confirmed by coronary angiography and consistent with the criteria of selection were enrolled in this study. The patients were divided into two groups according to flushing or not after drinking wine: non-flushing group (n = 88) and flushing group (n = 54). The genotypes of ALDH2 were determined with polymerase chain reaction and direct sequencing. The efficacy of nitroglycerin on angina pectoris attacks for all the patients were obtained by observation and inquiry. Basal clinical data and nitroglycerin efficacy between the two groups were compared. RESULTS: The rate of efficacious response to GTN and ALDH2*1 genotype in non-flushing group were significantly higher than those in the flushing group (89.8% vs 37.0%, P < 0.01; 93.2% vs 44.4%, P < 0.01). The number of patients with angina pectoris attacks ameliorated by GTN in 5 minutes in the non-flushing group were remarkably higher than that in the flushing group (67.1% vs 20.4%, P < 0.01). The rate of efficacious response to GTN was significantly higher in the patients with ALDH2*1 genotype than the patients with ALDH2*2 genotype (81.1% vs 36.1%, P < 0.01) and the efficacious response to GTN in 5 minutes was higher in the patients with ALDH2*1 genotype than those with ALDH2*2 genotype (57.5% vs 11.1%, P < 0.01). CONCLUSIONS: There is relationship among ALDH2 gene polymorphisms, alcohol flushing and efficacy of nitroglycerin. The rate of efficacious response to GTN is significantly higher in non-flushing patients; this may be explained by the effect of gene polymorphisms. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/17967228/[The_relationship_between_aldehyde_dehydrogenase_2_gene_polymorphisms_and_efficacy_of_nitroglycerin]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0578-1426&amp;year=2007&amp;vol=46&amp;issue=8&amp;fpage=629 DB - PRIME DP - Unbound Medicine ER -