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Effect of subcutaneous apomorphine on tremor in idiopathic Parkinson's disease.
Biomed Pharmacother. 2008 Apr-May; 62(4):250-2.BP

Abstract

Among the cardinal symptoms of Parkinson's disease (PD) rest tremor is the least responsive to dopaminergic treatment, raising the assumption that it may not be directly related to the loss of dopaminergic neurons. Apomorphine is a potent short-acting dopamine agonist that rapidly ameliorates symptoms of PD. The aim of this study was to evaluate the extent to which apomorphine can suppress tremor in patients with idiopathic PD compared to other symptoms. The study group included 18 patients with Parkinson's disease. Increasing doses of 1mg, 2mg, and 4 mg of subcutaneous apomorphine were used. Treatment response was assessed with the motor section of the unified Parkinson's disease rating scale (UPDRS). Tremor, rigidity and bradykinesia were scored using specific items of the UPDRS. UPDRS motor score improved from 31.5+/-9 at baseline to 20.0+/-6.4 after treatment. The scores for tremor, bradykinesia and rigidity improved after administration of apomorphine. The improvement in each of these scores for each individual patient was not significantly different, i.e., the magnitude of improvement was similar for all symptoms. These results indicate that subcutaneous apomorphine appears to be as effective in the treatment of tremor in Parkinson's disease as compared to the other symptoms.

Authors+Show Affiliations

Department of Neurology, Rabin Medical Center, Petah Tiqva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17967525

Citation

Hellmann, Mark A., et al. "Effect of Subcutaneous Apomorphine On Tremor in Idiopathic Parkinson's Disease." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 62, no. 4, 2008, pp. 250-2.
Hellmann MA, Sabach T, Melamed E, et al. Effect of subcutaneous apomorphine on tremor in idiopathic Parkinson's disease. Biomed Pharmacother. 2008;62(4):250-2.
Hellmann, M. A., Sabach, T., Melamed, E., & Djaldetti, R. (2008). Effect of subcutaneous apomorphine on tremor in idiopathic Parkinson's disease. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 62(4), 250-2.
Hellmann MA, et al. Effect of Subcutaneous Apomorphine On Tremor in Idiopathic Parkinson's Disease. Biomed Pharmacother. 2008 Apr-May;62(4):250-2. PubMed PMID: 17967525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of subcutaneous apomorphine on tremor in idiopathic Parkinson's disease. AU - Hellmann,Mark A, AU - Sabach,Tilda, AU - Melamed,Eldad, AU - Djaldetti,Ruth, Y1 - 2007/10/05/ PY - 2007/09/05/received PY - 2007/09/11/accepted PY - 2007/10/31/pubmed PY - 2008/8/20/medline PY - 2007/10/31/entrez SP - 250 EP - 2 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 62 IS - 4 N2 - Among the cardinal symptoms of Parkinson's disease (PD) rest tremor is the least responsive to dopaminergic treatment, raising the assumption that it may not be directly related to the loss of dopaminergic neurons. Apomorphine is a potent short-acting dopamine agonist that rapidly ameliorates symptoms of PD. The aim of this study was to evaluate the extent to which apomorphine can suppress tremor in patients with idiopathic PD compared to other symptoms. The study group included 18 patients with Parkinson's disease. Increasing doses of 1mg, 2mg, and 4 mg of subcutaneous apomorphine were used. Treatment response was assessed with the motor section of the unified Parkinson's disease rating scale (UPDRS). Tremor, rigidity and bradykinesia were scored using specific items of the UPDRS. UPDRS motor score improved from 31.5+/-9 at baseline to 20.0+/-6.4 after treatment. The scores for tremor, bradykinesia and rigidity improved after administration of apomorphine. The improvement in each of these scores for each individual patient was not significantly different, i.e., the magnitude of improvement was similar for all symptoms. These results indicate that subcutaneous apomorphine appears to be as effective in the treatment of tremor in Parkinson's disease as compared to the other symptoms. SN - 0753-3322 UR - https://www.unboundmedicine.com/medline/citation/17967525/Effect_of_subcutaneous_apomorphine_on_tremor_in_idiopathic_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(07)00208-9 DB - PRIME DP - Unbound Medicine ER -