Tags

Type your tag names separated by a space and hit enter

Sensitivity and specificity of a new indicator test (Neuropad) for the diagnosis of peripheral neuropathy in type 2 diabetes patients: a comparison with clinical examination and nerve conduction study.
J Diabetes Complications. 2007 Nov-Dec; 21(6):353-8.JD

Abstract

OBJECTIVE

The objective of this study was to evaluate the sensitivity and specificity of a new indicator test (Neuropad) for the diagnosis of peripheral neuropathy in type 2 diabetes patients as compared with clinical examination and nerve conduction study (NCS).

PATIENTS AND METHODS

This study included 120 type 2 diabetes patients (58 men) with a mean age of 67.3 +/- 5.9 years and a mean diabetes duration of 13.1 +/- 3.2 years. Diabetic neuropathy was diagnosed through the Neuropathy Disability Score. An NCS was performed on radial, ulnar, sural, and common and deep peroneal nerves. Patients were also examined with the new indicator test. The "time to complete color change of the test" from blue to pink was recorded. The test was considered abnormal in patients who exhibited a time to complete color change of the test exceeding 600 s in at least one foot.

RESULTS

Neuropathy was diagnosed by clinical examination in 83 (69.2%) patients. The sensitivity of the indicator test for clinical neuropathy was 95.2%, and its specificity was 67.6%. The sensitivity of NCS for clinical neuropathy was 94%, and its specificity was 62.1%. The sensitivity of the indicator test for abnormal NCS was 97.8%, and its specificity was 96.4%.

CONCLUSIONS

The new indicator test has a very high sensitivity not only for the diagnosis of clinical neuropathy but also for the diagnosis of neurophysiological neuropathy. Specificity is moderately high for the diagnosis of clinical neuropathy, while it is particularly high for the diagnosis of neurophysiological neuropathy. The indicator test has a validity comparable to that of NCS for the diagnosis of diabetic neuropathy. Finally, the time to complete color change of the test is associated with the severity of nerve conduction impairment.

Authors+Show Affiliations

Second Department of Internal Medicine, Democritus University of Thrace, Greece. papanasnikos@yahoo.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17967706

Citation

Papanas, Nikolaos, et al. "Sensitivity and Specificity of a New Indicator Test (Neuropad) for the Diagnosis of Peripheral Neuropathy in Type 2 Diabetes Patients: a Comparison With Clinical Examination and Nerve Conduction Study." Journal of Diabetes and Its Complications, vol. 21, no. 6, 2007, pp. 353-8.
Papanas N, Giassakis G, Papatheodorou K, et al. Sensitivity and specificity of a new indicator test (Neuropad) for the diagnosis of peripheral neuropathy in type 2 diabetes patients: a comparison with clinical examination and nerve conduction study. J Diabetes Complications. 2007;21(6):353-8.
Papanas, N., Giassakis, G., Papatheodorou, K., Papazoglou, D., Monastiriotis, C., Christakidis, D., Piperidou, H., & Maltezos, E. (2007). Sensitivity and specificity of a new indicator test (Neuropad) for the diagnosis of peripheral neuropathy in type 2 diabetes patients: a comparison with clinical examination and nerve conduction study. Journal of Diabetes and Its Complications, 21(6), 353-8.
Papanas N, et al. Sensitivity and Specificity of a New Indicator Test (Neuropad) for the Diagnosis of Peripheral Neuropathy in Type 2 Diabetes Patients: a Comparison With Clinical Examination and Nerve Conduction Study. J Diabetes Complications. 2007 Nov-Dec;21(6):353-8. PubMed PMID: 17967706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitivity and specificity of a new indicator test (Neuropad) for the diagnosis of peripheral neuropathy in type 2 diabetes patients: a comparison with clinical examination and nerve conduction study. AU - Papanas,Nikolaos, AU - Giassakis,Georgios, AU - Papatheodorou,Konstantinos, AU - Papazoglou,Dimitrios, AU - Monastiriotis,Christodoulos, AU - Christakidis,Dimitrios, AU - Piperidou,Haritomeni, AU - Maltezos,Efstratios, PY - 2006/03/23/received PY - 2006/08/02/revised PY - 2006/08/21/accepted PY - 2007/10/31/pubmed PY - 2007/12/22/medline PY - 2007/10/31/entrez SP - 353 EP - 8 JF - Journal of diabetes and its complications JO - J Diabetes Complications VL - 21 IS - 6 N2 - OBJECTIVE: The objective of this study was to evaluate the sensitivity and specificity of a new indicator test (Neuropad) for the diagnosis of peripheral neuropathy in type 2 diabetes patients as compared with clinical examination and nerve conduction study (NCS). PATIENTS AND METHODS: This study included 120 type 2 diabetes patients (58 men) with a mean age of 67.3 +/- 5.9 years and a mean diabetes duration of 13.1 +/- 3.2 years. Diabetic neuropathy was diagnosed through the Neuropathy Disability Score. An NCS was performed on radial, ulnar, sural, and common and deep peroneal nerves. Patients were also examined with the new indicator test. The "time to complete color change of the test" from blue to pink was recorded. The test was considered abnormal in patients who exhibited a time to complete color change of the test exceeding 600 s in at least one foot. RESULTS: Neuropathy was diagnosed by clinical examination in 83 (69.2%) patients. The sensitivity of the indicator test for clinical neuropathy was 95.2%, and its specificity was 67.6%. The sensitivity of NCS for clinical neuropathy was 94%, and its specificity was 62.1%. The sensitivity of the indicator test for abnormal NCS was 97.8%, and its specificity was 96.4%. CONCLUSIONS: The new indicator test has a very high sensitivity not only for the diagnosis of clinical neuropathy but also for the diagnosis of neurophysiological neuropathy. Specificity is moderately high for the diagnosis of clinical neuropathy, while it is particularly high for the diagnosis of neurophysiological neuropathy. The indicator test has a validity comparable to that of NCS for the diagnosis of diabetic neuropathy. Finally, the time to complete color change of the test is associated with the severity of nerve conduction impairment. SN - 1056-8727 UR - https://www.unboundmedicine.com/medline/citation/17967706/Sensitivity_and_specificity_of_a_new_indicator_test__Neuropad__for_the_diagnosis_of_peripheral_neuropathy_in_type_2_diabetes_patients:_a_comparison_with_clinical_examination_and_nerve_conduction_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(06)00091-2 DB - PRIME DP - Unbound Medicine ER -