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Ankle-to-brachial index and dementia: the Honolulu-Asia Aging Study.
Circulation 2007; 116(20):2269-74Circ

Abstract

BACKGROUND

Measurement of the ankle-to-brachial index (ABI) is a noninvasive test to assess peripheral arterial disease. A low ABI is a strong correlate of cardiovascular disease and subsequent mortality. Evidence indicates the existence of vascular components in the pathogenesis of dementia. Here, we examine the association of ABI with dementia and subtypes.

METHODS AND RESULTS

Data are from the Honolulu-Asia Aging Study (HAAS), a prospective community-based study of 3734 Japanese American men 71 to 93 years of age at baseline in 1991 to 1993. The analysis included 2588 men who were free of dementia at the first assessment, had an ABI measure, and were examined up to 2 more times for dementia between 1994 and 1999. The sample included 240 incident cases of dementia (144 of Alzheimer's disease, 46 of vascular dementia, and 50 of dementia of other causes). Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated from Cox proportional-hazards models with age as the time scale after adjustment for education, year of birth, high blood pressure, body mass index, diabetes mellitus, cholesterol concentration, smoking status, alcohol consumption, and apolipoprotein E epsilon4 allele. A low ABI was associated with an increased risk of dementia and vascular dementia (HR, 1.66; 95% CI, 1.16 to 2.37; and HR, 2.25; 95% CI, 1.07 to 4.73, respectively). ABI was weakly associated with Alzheimer's disease (HR, 1.57; 95% CI, 0.98 to 2.53), particularly in the apolipoprotein E epsilon4 carriers (HR, 1.43; 95% CI, 1.02 to 1.96).

CONCLUSIONS

These results suggest that ABI, a measure of atherosclerosis, is associated with the incidence of total dementia, vascular dementia, and Alzheimer's disease in carriers of the apolipoprotein E epsilon4 allele.

Authors+Show Affiliations

Laval University Geriatrics Research Unit, Centre de recherche du CHA, and Faculty of Pharmacy, Laval University, Quebec City, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

17967779

Citation

Laurin, Danielle, et al. "Ankle-to-brachial Index and Dementia: the Honolulu-Asia Aging Study." Circulation, vol. 116, no. 20, 2007, pp. 2269-74.
Laurin D, Masaki KH, White LR, et al. Ankle-to-brachial index and dementia: the Honolulu-Asia Aging Study. Circulation. 2007;116(20):2269-74.
Laurin, D., Masaki, K. H., White, L. R., & Launer, L. J. (2007). Ankle-to-brachial index and dementia: the Honolulu-Asia Aging Study. Circulation, 116(20), pp. 2269-74.
Laurin D, et al. Ankle-to-brachial Index and Dementia: the Honolulu-Asia Aging Study. Circulation. 2007 Nov 13;116(20):2269-74. PubMed PMID: 17967779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ankle-to-brachial index and dementia: the Honolulu-Asia Aging Study. AU - Laurin,Danielle, AU - Masaki,Kamal H, AU - White,Lon R, AU - Launer,Lenore J, Y1 - 2007/10/22/ PY - 2007/10/31/pubmed PY - 2007/12/19/medline PY - 2007/10/31/entrez SP - 2269 EP - 74 JF - Circulation JO - Circulation VL - 116 IS - 20 N2 - BACKGROUND: Measurement of the ankle-to-brachial index (ABI) is a noninvasive test to assess peripheral arterial disease. A low ABI is a strong correlate of cardiovascular disease and subsequent mortality. Evidence indicates the existence of vascular components in the pathogenesis of dementia. Here, we examine the association of ABI with dementia and subtypes. METHODS AND RESULTS: Data are from the Honolulu-Asia Aging Study (HAAS), a prospective community-based study of 3734 Japanese American men 71 to 93 years of age at baseline in 1991 to 1993. The analysis included 2588 men who were free of dementia at the first assessment, had an ABI measure, and were examined up to 2 more times for dementia between 1994 and 1999. The sample included 240 incident cases of dementia (144 of Alzheimer's disease, 46 of vascular dementia, and 50 of dementia of other causes). Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated from Cox proportional-hazards models with age as the time scale after adjustment for education, year of birth, high blood pressure, body mass index, diabetes mellitus, cholesterol concentration, smoking status, alcohol consumption, and apolipoprotein E epsilon4 allele. A low ABI was associated with an increased risk of dementia and vascular dementia (HR, 1.66; 95% CI, 1.16 to 2.37; and HR, 2.25; 95% CI, 1.07 to 4.73, respectively). ABI was weakly associated with Alzheimer's disease (HR, 1.57; 95% CI, 0.98 to 2.53), particularly in the apolipoprotein E epsilon4 carriers (HR, 1.43; 95% CI, 1.02 to 1.96). CONCLUSIONS: These results suggest that ABI, a measure of atherosclerosis, is associated with the incidence of total dementia, vascular dementia, and Alzheimer's disease in carriers of the apolipoprotein E epsilon4 allele. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/17967779/Ankle_to_brachial_index_and_dementia:_the_Honolulu_Asia_Aging_Study_ L2 - http://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.106.686477?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -