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Inhibitory effect of inhalation of a thromboxane synthetase inhibitor on bronchoconstriction induced by aerosolized leukotriene C4 and thromboxane A2 analogue in anesthetized guinea pigs.
Allergy. 1991 Oct; 46(7):534-9.A

Abstract

Effect of aerosol administration of a thromboxane synthetase inhibitor (OKY-046) on bronchoconstriction induced by aerosol leukotriene C4, histamine and a thromboxane A2 analogue (STA2) was studied in anesthetized, artificially ventilated guinea pigs in order to evaluate the effectiveness of inhalation of OKY-046 on an unfavorable mechanism of secondary release of thromboxane A2. 0.01-1.0 micrograms/ml leukotriene C4, 25-400 micrograms/ml histamine and 0.033-1.0 micrograms/ml STA2 inhaled from an ultrasonic nebulizer developed for small animals caused a dose-dependent increase of pressure at the airway opening (Pao), which is considered to be an index representing bronchial response. Pretreatment of the animals with aerosol OKY-046 (0.035 and 0.35 mg/animal) significantly reduced the airway responses produced by inhalation of leukotriene C4 and STA2, in a dose-dependent manner, while the pretreatment did not affect the histamine dose-response curve. These findings suggest that aerosol leukotriene C4 and STA2 activate thromboxane synthesis in the airway, and inhalation of OKY-046 may be useful for preventing the secondary release of thromboxane A2, which is an unfavorable mechanism in asthma.

Authors+Show Affiliations

Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1796779

Citation

Fujimura, M, et al. "Inhibitory Effect of Inhalation of a Thromboxane Synthetase Inhibitor On Bronchoconstriction Induced By Aerosolized Leukotriene C4 and Thromboxane A2 Analogue in Anesthetized Guinea Pigs." Allergy, vol. 46, no. 7, 1991, pp. 534-9.
Fujimura M, Ogawa H, Saito M, et al. Inhibitory effect of inhalation of a thromboxane synthetase inhibitor on bronchoconstriction induced by aerosolized leukotriene C4 and thromboxane A2 analogue in anesthetized guinea pigs. Allergy. 1991;46(7):534-9.
Fujimura, M., Ogawa, H., Saito, M., Sakamoto, S., Miyake, Y., & Matsuda, T. (1991). Inhibitory effect of inhalation of a thromboxane synthetase inhibitor on bronchoconstriction induced by aerosolized leukotriene C4 and thromboxane A2 analogue in anesthetized guinea pigs. Allergy, 46(7), 534-9.
Fujimura M, et al. Inhibitory Effect of Inhalation of a Thromboxane Synthetase Inhibitor On Bronchoconstriction Induced By Aerosolized Leukotriene C4 and Thromboxane A2 Analogue in Anesthetized Guinea Pigs. Allergy. 1991;46(7):534-9. PubMed PMID: 1796779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of inhalation of a thromboxane synthetase inhibitor on bronchoconstriction induced by aerosolized leukotriene C4 and thromboxane A2 analogue in anesthetized guinea pigs. AU - Fujimura,M, AU - Ogawa,H, AU - Saito,M, AU - Sakamoto,S, AU - Miyake,Y, AU - Matsuda,T, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 534 EP - 9 JF - Allergy JO - Allergy VL - 46 IS - 7 N2 - Effect of aerosol administration of a thromboxane synthetase inhibitor (OKY-046) on bronchoconstriction induced by aerosol leukotriene C4, histamine and a thromboxane A2 analogue (STA2) was studied in anesthetized, artificially ventilated guinea pigs in order to evaluate the effectiveness of inhalation of OKY-046 on an unfavorable mechanism of secondary release of thromboxane A2. 0.01-1.0 micrograms/ml leukotriene C4, 25-400 micrograms/ml histamine and 0.033-1.0 micrograms/ml STA2 inhaled from an ultrasonic nebulizer developed for small animals caused a dose-dependent increase of pressure at the airway opening (Pao), which is considered to be an index representing bronchial response. Pretreatment of the animals with aerosol OKY-046 (0.035 and 0.35 mg/animal) significantly reduced the airway responses produced by inhalation of leukotriene C4 and STA2, in a dose-dependent manner, while the pretreatment did not affect the histamine dose-response curve. These findings suggest that aerosol leukotriene C4 and STA2 activate thromboxane synthesis in the airway, and inhalation of OKY-046 may be useful for preventing the secondary release of thromboxane A2, which is an unfavorable mechanism in asthma. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/1796779/Inhibitory_effect_of_inhalation_of_a_thromboxane_synthetase_inhibitor_on_bronchoconstriction_induced_by_aerosolized_leukotriene_C4_and_thromboxane_A2_analogue_in_anesthetized_guinea_pigs_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=1991&volume=46&issue=7&spage=534 DB - PRIME DP - Unbound Medicine ER -