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Inhibitory effect of inhalation of a thromboxane synthetase inhibitor on bronchoconstriction induced by aerosolized leukotriene C4 and thromboxane A2 analogue in anesthetized guinea pigs.
Allergy. 1991 Oct; 46(7):534-9.A

Abstract

Effect of aerosol administration of a thromboxane synthetase inhibitor (OKY-046) on bronchoconstriction induced by aerosol leukotriene C4, histamine and a thromboxane A2 analogue (STA2) was studied in anesthetized, artificially ventilated guinea pigs in order to evaluate the effectiveness of inhalation of OKY-046 on an unfavorable mechanism of secondary release of thromboxane A2. 0.01-1.0 micrograms/ml leukotriene C4, 25-400 micrograms/ml histamine and 0.033-1.0 micrograms/ml STA2 inhaled from an ultrasonic nebulizer developed for small animals caused a dose-dependent increase of pressure at the airway opening (Pao), which is considered to be an index representing bronchial response. Pretreatment of the animals with aerosol OKY-046 (0.035 and 0.35 mg/animal) significantly reduced the airway responses produced by inhalation of leukotriene C4 and STA2, in a dose-dependent manner, while the pretreatment did not affect the histamine dose-response curve. These findings suggest that aerosol leukotriene C4 and STA2 activate thromboxane synthesis in the airway, and inhalation of OKY-046 may be useful for preventing the secondary release of thromboxane A2, which is an unfavorable mechanism in asthma.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Fujimura M
    Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan.
    Ogawa H
    No affiliation info available
    Saito M
    No affiliation info available
    Sakamoto S
    No affiliation info available
    Miyake Y
    No affiliation info available
    Matsuda T
    No affiliation info available

    MeSH

    Administration, InhalationAnimalsBronchoconstrictionDose-Response Relationship, DrugGuinea PigsInjections, IntraperitonealMaleMethacrylatesSRS-AThromboxane A2Thromboxane-A Synthase

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    1796779

    Citation

    Fujimura, M, et al. "Inhibitory Effect of Inhalation of a Thromboxane Synthetase Inhibitor On Bronchoconstriction Induced By Aerosolized Leukotriene C4 and Thromboxane A2 Analogue in Anesthetized Guinea Pigs." Allergy, vol. 46, no. 7, 1991, pp. 534-9.
    Fujimura M, Ogawa H, Saito M, et al. Inhibitory effect of inhalation of a thromboxane synthetase inhibitor on bronchoconstriction induced by aerosolized leukotriene C4 and thromboxane A2 analogue in anesthetized guinea pigs. Allergy. 1991;46(7):534-9.
    Fujimura, M., Ogawa, H., Saito, M., Sakamoto, S., Miyake, Y., & Matsuda, T. (1991). Inhibitory effect of inhalation of a thromboxane synthetase inhibitor on bronchoconstriction induced by aerosolized leukotriene C4 and thromboxane A2 analogue in anesthetized guinea pigs. Allergy, 46(7), 534-9.
    Fujimura M, et al. Inhibitory Effect of Inhalation of a Thromboxane Synthetase Inhibitor On Bronchoconstriction Induced By Aerosolized Leukotriene C4 and Thromboxane A2 Analogue in Anesthetized Guinea Pigs. Allergy. 1991;46(7):534-9. PubMed PMID: 1796779.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Inhibitory effect of inhalation of a thromboxane synthetase inhibitor on bronchoconstriction induced by aerosolized leukotriene C4 and thromboxane A2 analogue in anesthetized guinea pigs. AU - Fujimura,M, AU - Ogawa,H, AU - Saito,M, AU - Sakamoto,S, AU - Miyake,Y, AU - Matsuda,T, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 534 EP - 9 JF - Allergy JO - Allergy VL - 46 IS - 7 N2 - Effect of aerosol administration of a thromboxane synthetase inhibitor (OKY-046) on bronchoconstriction induced by aerosol leukotriene C4, histamine and a thromboxane A2 analogue (STA2) was studied in anesthetized, artificially ventilated guinea pigs in order to evaluate the effectiveness of inhalation of OKY-046 on an unfavorable mechanism of secondary release of thromboxane A2. 0.01-1.0 micrograms/ml leukotriene C4, 25-400 micrograms/ml histamine and 0.033-1.0 micrograms/ml STA2 inhaled from an ultrasonic nebulizer developed for small animals caused a dose-dependent increase of pressure at the airway opening (Pao), which is considered to be an index representing bronchial response. Pretreatment of the animals with aerosol OKY-046 (0.035 and 0.35 mg/animal) significantly reduced the airway responses produced by inhalation of leukotriene C4 and STA2, in a dose-dependent manner, while the pretreatment did not affect the histamine dose-response curve. These findings suggest that aerosol leukotriene C4 and STA2 activate thromboxane synthesis in the airway, and inhalation of OKY-046 may be useful for preventing the secondary release of thromboxane A2, which is an unfavorable mechanism in asthma. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/1796779/Inhibitory_effect_of_inhalation_of_a_thromboxane_synthetase_inhibitor_on_bronchoconstriction_induced_by_aerosolized_leukotriene_C4_and_thromboxane_A2_analogue_in_anesthetized_guinea_pigs_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=1991&volume=46&issue=7&spage=534 DB - PRIME DP - Unbound Medicine ER -

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