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Efficacy and safety of intraarticular hylan or hyaluronic acids for osteoarthritis of the knee: a randomized controlled trial.
Arthritis Rheum. 2007 Nov; 56(11):3610-9.AR

Abstract

OBJECTIVE

To compare the efficacy and safety of intraarticular hylan and 2 hyaluronic acids (HAs) in osteoarthritis (OA) of the knee.

METHODS

This was a multicenter, patient-blind, randomized controlled trial in 660 patients with symptomatic knee OA. Patients were randomly assigned to receive 1 cycle of 3 intraarticular injections per knee of 1 of 3 preparations: a high molecular weight cross-linked hylan, a non-cross-linked medium molecular weight HA of avian origin, or a non-cross-linked low molecular weight HA of bacterial origin. The primary outcome measure was the change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score at 6 months. Secondary outcome measures included local adverse events (effusions or flares) in injected knees. During months 7-12, patients were offered a second cycle of viscosupplementation.

RESULTS

Pain relief was similar in all 3 groups. The difference in changes between baseline and 6 months between hylan and the combined HAs was 0.1 on the WOMAC pain score (95% confidence interval [95% CI] -0.2, 0.3). No relevant differences were observed in any of the secondary efficacy outcomes, and stratified analyses provided no evidence for differences in effects across different patient groups. There was a trend toward more local adverse events in the hylan group than in the HA groups during the first cycle (difference 2.2% [95% CI -2.4, 6.7]), and this trend became more pronounced during the second cycle (difference 6.4% [95% CI 0.6, 12.2]).

CONCLUSION

We found no evidence for a difference in efficacy between hylan and HAs. In view of its higher costs and potential for more local adverse events, we see no rationale for the continued use of hylan in patients with knee OA.

Authors+Show Affiliations

University of Berne, Berne, Switzerland. juni@ispm.unibe.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17968921

Citation

Jüni, Peter, et al. "Efficacy and Safety of Intraarticular Hylan or Hyaluronic Acids for Osteoarthritis of the Knee: a Randomized Controlled Trial." Arthritis and Rheumatism, vol. 56, no. 11, 2007, pp. 3610-9.
Jüni P, Reichenbach S, Trelle S, et al. Efficacy and safety of intraarticular hylan or hyaluronic acids for osteoarthritis of the knee: a randomized controlled trial. Arthritis Rheum. 2007;56(11):3610-9.
Jüni, P., Reichenbach, S., Trelle, S., Tschannen, B., Wandel, S., Jordi, B., Züllig, M., Guetg, R., Häuselmann, H. J., Schwarz, H., Theiler, R., Ziswiler, H. R., Dieppe, P. A., Villiger, P. M., & Egger, M. (2007). Efficacy and safety of intraarticular hylan or hyaluronic acids for osteoarthritis of the knee: a randomized controlled trial. Arthritis and Rheumatism, 56(11), 3610-9.
Jüni P, et al. Efficacy and Safety of Intraarticular Hylan or Hyaluronic Acids for Osteoarthritis of the Knee: a Randomized Controlled Trial. Arthritis Rheum. 2007;56(11):3610-9. PubMed PMID: 17968921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of intraarticular hylan or hyaluronic acids for osteoarthritis of the knee: a randomized controlled trial. AU - Jüni,Peter, AU - Reichenbach,Stephan, AU - Trelle,Sven, AU - Tschannen,Beatrice, AU - Wandel,Simon, AU - Jordi,Beat, AU - Züllig,Maya, AU - Guetg,Reto, AU - Häuselmann,Hans Jörg, AU - Schwarz,Hans, AU - Theiler,Robert, AU - Ziswiler,Hans Rudolf, AU - Dieppe,Paul A, AU - Villiger,Peter M, AU - Egger,Matthias, AU - ,, PY - 2007/10/31/pubmed PY - 2007/12/20/medline PY - 2007/10/31/entrez SP - 3610 EP - 9 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 56 IS - 11 N2 - OBJECTIVE: To compare the efficacy and safety of intraarticular hylan and 2 hyaluronic acids (HAs) in osteoarthritis (OA) of the knee. METHODS: This was a multicenter, patient-blind, randomized controlled trial in 660 patients with symptomatic knee OA. Patients were randomly assigned to receive 1 cycle of 3 intraarticular injections per knee of 1 of 3 preparations: a high molecular weight cross-linked hylan, a non-cross-linked medium molecular weight HA of avian origin, or a non-cross-linked low molecular weight HA of bacterial origin. The primary outcome measure was the change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score at 6 months. Secondary outcome measures included local adverse events (effusions or flares) in injected knees. During months 7-12, patients were offered a second cycle of viscosupplementation. RESULTS: Pain relief was similar in all 3 groups. The difference in changes between baseline and 6 months between hylan and the combined HAs was 0.1 on the WOMAC pain score (95% confidence interval [95% CI] -0.2, 0.3). No relevant differences were observed in any of the secondary efficacy outcomes, and stratified analyses provided no evidence for differences in effects across different patient groups. There was a trend toward more local adverse events in the hylan group than in the HA groups during the first cycle (difference 2.2% [95% CI -2.4, 6.7]), and this trend became more pronounced during the second cycle (difference 6.4% [95% CI 0.6, 12.2]). CONCLUSION: We found no evidence for a difference in efficacy between hylan and HAs. In view of its higher costs and potential for more local adverse events, we see no rationale for the continued use of hylan in patients with knee OA. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/17968921/Efficacy_and_safety_of_intraarticular_hylan_or_hyaluronic_acids_for_osteoarthritis_of_the_knee:_a_randomized_controlled_trial_ L2 - https://doi.org/10.1002/art.23026 DB - PRIME DP - Unbound Medicine ER -