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Cytotoxic activity of essential oils from labiatae and lauraceae families against in vitro human tumor models.
Anticancer Res. 2007 Sep-Oct; 27(5A):3293-9.AR

Abstract

BACKGROUND

The aim of this work was to study the cytotoxicity of essential oils and their identified constituents from Sideritis perfoliata, Satureia thymbra, Salvia officinalis, Laurus nobilis and Pistacia palestina.

MATERIALS AND METHODS

Essential oils were obtained by hydrodistillation and were analysed by gas chromatography (GC) and GC/mass spectrometry (MS). The cytotoxic activity was evaluated in amelanotic melanoma C32, renal cell adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP, and MCF-7 breast cancer cell lines by the sulforhodamine B (SRB) assay.

RESULTS

L. nobilis fruit oil exerted the highest activity with IC50 values on C32 and ACHN of 75.45 and 78.24 microg/ml, respectively. The activity of S. perfoliata oil on both cell lines (IC50 of 100.90 mg/ml for C32 and 98.58 microg/ml for ACHN, respectively) was also interesting. Among the tested constituents the highest activity was found when a-humulene was applied to LNCaP cells (IC50 of 11.24 microg/ml).

CONCLUSION

This study suggests for the first time the ability of S. perfoliata, S. thymbra, S. officinalis, L. nobilis and P. palestina essential oils and some identified terpenes to inhibit human tumor cell growth.

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Authors+Show Affiliations

Loizzo MR
Faculty of Pharmacy, Nutrition and Health Sciences, Department of Pharmaceutical Sciences, University of Calabria, 1-87036 Rende (CS), Italy. mr.loizzo@unical.it
Tundis R
No affiliation info available
Menichini F
No affiliation info available
Saab AM
No affiliation info available
Statti GA
No affiliation info available
Menichini F
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicCell Line, TumorDrug Screening Assays, AntitumorGas Chromatography-Mass SpectrometryHumansLamiaceaeLauraceaeOils, VolatilePlant Extracts

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17970073

Citation

Loizzo, Monica Rosa, et al. "Cytotoxic Activity of Essential Oils From Labiatae and Lauraceae Families Against in Vitro Human Tumor Models." Anticancer Research, vol. 27, no. 5A, 2007, pp. 3293-9.
Loizzo MR, Tundis R, Menichini F, et al. Cytotoxic activity of essential oils from labiatae and lauraceae families against in vitro human tumor models. Anticancer Res. 2007;27(5A):3293-9.
Loizzo, M. R., Tundis, R., Menichini, F., Saab, A. M., Statti, G. A., & Menichini, F. (2007). Cytotoxic activity of essential oils from labiatae and lauraceae families against in vitro human tumor models. Anticancer Research, 27(5A), 3293-9.
Loizzo MR, et al. Cytotoxic Activity of Essential Oils From Labiatae and Lauraceae Families Against in Vitro Human Tumor Models. Anticancer Res. 2007 Sep-Oct;27(5A):3293-9. PubMed PMID: 17970073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic activity of essential oils from labiatae and lauraceae families against in vitro human tumor models. AU - Loizzo,Monica Rosa, AU - Tundis,Rosa, AU - Menichini,Federica, AU - Saab,Antoine Mikael, AU - Statti,Giancarlo Antonio, AU - Menichini,Francesco, PY - 2007/11/1/pubmed PY - 2007/12/6/medline PY - 2007/11/1/entrez SP - 3293 EP - 9 JF - Anticancer research JO - Anticancer Res VL - 27 IS - 5A N2 - BACKGROUND: The aim of this work was to study the cytotoxicity of essential oils and their identified constituents from Sideritis perfoliata, Satureia thymbra, Salvia officinalis, Laurus nobilis and Pistacia palestina. MATERIALS AND METHODS: Essential oils were obtained by hydrodistillation and were analysed by gas chromatography (GC) and GC/mass spectrometry (MS). The cytotoxic activity was evaluated in amelanotic melanoma C32, renal cell adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP, and MCF-7 breast cancer cell lines by the sulforhodamine B (SRB) assay. RESULTS: L. nobilis fruit oil exerted the highest activity with IC50 values on C32 and ACHN of 75.45 and 78.24 microg/ml, respectively. The activity of S. perfoliata oil on both cell lines (IC50 of 100.90 mg/ml for C32 and 98.58 microg/ml for ACHN, respectively) was also interesting. Among the tested constituents the highest activity was found when a-humulene was applied to LNCaP cells (IC50 of 11.24 microg/ml). CONCLUSION: This study suggests for the first time the ability of S. perfoliata, S. thymbra, S. officinalis, L. nobilis and P. palestina essential oils and some identified terpenes to inhibit human tumor cell growth. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/17970073/Cytotoxic_activity_of_essential_oils_from_labiatae_and_lauraceae_families_against_in_vitro_human_tumor_models_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=17970073 DB - PRIME DP - Unbound Medicine ER -