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Cytotoxic sesquiterpene lactones from Pseudoelephantopus spicatus.
J Nat Prod. 2007 Nov; 70(11):1761-5.JN

Abstract

Five new sesquiterpene lactones, spicatolides D-H (1-5), along with four known compounds, pitocarphin D (6), 8 alpha-acetoxy-10 alpha-hydroxy-13-O-methylhirsutinolide (7), spicatolide A (8), and 13-O-methylvernojalcanolide 8-O-acetate (9), were isolated from an ethyl acetate extract of the aerial parts of Pseudoelephantopus spicatus. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. All of the compounds isolated were evaluated for their cytotoxic effects against five human cancer cell lines. Compounds 1, 3, and 4 showed cytotoxicity (IC50 < 5 micro g/mL) against the Hep3B and MCF-7 cancer cell lines.

Authors+Show Affiliations

Yang YL
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
Chang SM
No affiliation info available
Wu CC
No affiliation info available
Hsieh PW
No affiliation info available
Chen SL
No affiliation info available
Chang FR
No affiliation info available
Hung WC
No affiliation info available
Issa HH
No affiliation info available
Wu YC
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicAsteraceaeDrug Screening Assays, AntitumorHumansLactonesMolecular ConformationMolecular StructurePlants, MedicinalSesquiterpenesTaiwan

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17970595

Citation

Yang, Yu-Liang, et al. "Cytotoxic Sesquiterpene Lactones From Pseudoelephantopus Spicatus." Journal of Natural Products, vol. 70, no. 11, 2007, pp. 1761-5.
Yang YL, Chang SM, Wu CC, et al. Cytotoxic sesquiterpene lactones from Pseudoelephantopus spicatus. J Nat Prod. 2007;70(11):1761-5.
Yang, Y. L., Chang, S. M., Wu, C. C., Hsieh, P. W., Chen, S. L., Chang, F. R., Hung, W. C., Issa, H. H., & Wu, Y. C. (2007). Cytotoxic sesquiterpene lactones from Pseudoelephantopus spicatus. Journal of Natural Products, 70(11), 1761-5.
Yang YL, et al. Cytotoxic Sesquiterpene Lactones From Pseudoelephantopus Spicatus. J Nat Prod. 2007;70(11):1761-5. PubMed PMID: 17970595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic sesquiterpene lactones from Pseudoelephantopus spicatus. AU - Yang,Yu-Liang, AU - Chang,Sue-Ming, AU - Wu,Ching-Chung, AU - Hsieh,Pei-Wen, AU - Chen,Shu-Li, AU - Chang,Fang-Rong, AU - Hung,Wen-Chun, AU - Issa,Hamad H, AU - Wu,Yang-Chang, Y1 - 2007/10/31/ PY - 2007/11/1/pubmed PY - 2008/1/8/medline PY - 2007/11/1/entrez SP - 1761 EP - 5 JF - Journal of natural products JO - J Nat Prod VL - 70 IS - 11 N2 - Five new sesquiterpene lactones, spicatolides D-H (1-5), along with four known compounds, pitocarphin D (6), 8 alpha-acetoxy-10 alpha-hydroxy-13-O-methylhirsutinolide (7), spicatolide A (8), and 13-O-methylvernojalcanolide 8-O-acetate (9), were isolated from an ethyl acetate extract of the aerial parts of Pseudoelephantopus spicatus. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. All of the compounds isolated were evaluated for their cytotoxic effects against five human cancer cell lines. Compounds 1, 3, and 4 showed cytotoxicity (IC50 < 5 micro g/mL) against the Hep3B and MCF-7 cancer cell lines. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/17970595/Cytotoxic_sesquiterpene_lactones_from_Pseudoelephantopus_spicatus_ DB - PRIME DP - Unbound Medicine ER -