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Use of tryptophan in combination with other antidepressant treatments: a review.
J Psychiatry Neurosci 1991; 16(5):241-6JP

Abstract

In four studies, all carried out more than 20 years ago, the combination of tryptophan plus a monoamine oxidase inhibitor was significantly better than tryptophan plus placebo in the treatment of depression. However, there is no evidence that tryptophan has any clinically significant effect on other treatments such as tricyclic antidepressants and ECT. Side effects of the combination of tryptophan and a monoamine oxidase inhibitors have limited the use of this combination. The risk of the serotonin syndrome is small, but it can occur. However, rapid cessation of tryptophan seems to avoid any long lasting adverse effects of the serotonin syndrome. In situations where enhancement of the therapeutic effect of monamine oxidase inhibitors outweighs the risk of adverse effects, the combination of tryptophan and a monoamine oxidase inhibitor is clinically useful. As the studies to date have looked at regular depressed patients, what is needed now is studies of this combination in therapy resistant depression.

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    • Authors+Show Affiliations

    Young SN
    Department of Psychiatry, McGill University, School of Dietetics and Human Nutrition, McGill University, Montréal, Canada.

    MeSH

    Antidepressive AgentsDepressive DisorderHumansTryptophan

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    1797098

    Citation

    Young, S N.. "Use of Tryptophan in Combination With Other Antidepressant Treatments: a Review." Journal of Psychiatry & Neuroscience : JPN, vol. 16, no. 5, 1991, pp. 241-6.
    Young SN. Use of tryptophan in combination with other antidepressant treatments: a review. J Psychiatry Neurosci. 1991;16(5):241-6.
    Young, S. N. (1991). Use of tryptophan in combination with other antidepressant treatments: a review. Journal of Psychiatry & Neuroscience : JPN, 16(5), pp. 241-6.
    Young SN. Use of Tryptophan in Combination With Other Antidepressant Treatments: a Review. J Psychiatry Neurosci. 1991;16(5):241-6. PubMed PMID: 1797098.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Use of tryptophan in combination with other antidepressant treatments: a review. A1 - Young,S N, PY - 1991/12/1/pubmed PY - 1991/12/1/medline PY - 1991/12/1/entrez SP - 241 EP - 6 JF - Journal of psychiatry & neuroscience : JPN JO - J Psychiatry Neurosci VL - 16 IS - 5 N2 - In four studies, all carried out more than 20 years ago, the combination of tryptophan plus a monoamine oxidase inhibitor was significantly better than tryptophan plus placebo in the treatment of depression. However, there is no evidence that tryptophan has any clinically significant effect on other treatments such as tricyclic antidepressants and ECT. Side effects of the combination of tryptophan and a monoamine oxidase inhibitors have limited the use of this combination. The risk of the serotonin syndrome is small, but it can occur. However, rapid cessation of tryptophan seems to avoid any long lasting adverse effects of the serotonin syndrome. In situations where enhancement of the therapeutic effect of monamine oxidase inhibitors outweighs the risk of adverse effects, the combination of tryptophan and a monoamine oxidase inhibitor is clinically useful. As the studies to date have looked at regular depressed patients, what is needed now is studies of this combination in therapy resistant depression. SN - 1180-4882 UR - https://www.unboundmedicine.com/medline/citation/1797098/Use_of_tryptophan_in_combination_with_other_antidepressant_treatments:_a_review_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1797098/ DB - PRIME DP - Unbound Medicine ER -