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Inverse correlation between activated protein C generation and carotid atherosclerosis in Type 2 diabetic patients.
Diabet Med. 2007 Dec; 24(12):1322-8.DM

Abstract

AIMS

Activated protein C (APC) is a key regulator of the clotting system and immune responses. We studied the relationship between the degree of atherosclerosis as measured by the intima-media thickness (IMT) of carotid artery and APC generation in Type 2 diabetic patients.

METHODS

Eighty-seven Type 2 diabetic patients and 35 control subjects participated. APC generation was assessed by the plasma APC-protein C inhibitor complex (APC-PCI) levels and the mean IMT of carotid artery was measured by ultrasonography. The plasma levels of the thrombin-anti-thromobin complex (TAT) and platelet-derived growth factor (PDGF) were measured by enzyme-linked immunoassays.

RESULTS

Plasma TAT levels were significantly higher in diabetic patients [2.03 (1.12, 2.56) ng/ml, median (25th, 75th percentile)] compared with control subjects [0.85 (0.55, 2.08) ng/ml, P < 0.01]. Plasma APC-PCI levels were significantly lower in diabetic patients [0.93 (0.74, 1.22) ng/ml], than in control subjects [1.66 (1.25, 2.36) ng/ml, P < 0.001]. The mean IMT was significantly increased in diabetic patients (0.881 +/- 0.242 mm; mean +/- sd) compared with control subjects (0.669 +/- 0.140 mm; P < 0.01). Univariate analysis showed a significant and inverse correlation between plasma APC-PCI levels and mean IMT (r = -0.32, P < 0.005), and multivariate regression analysis confirmed the independent correlation (P < 0.05). Moreover, plasma APC-PCI levels significantly and inversely correlated with plasma PDGF levels in diabetic patients (r = -0.30, P < 0.01).

CONCLUSIONS

These results suggest that decreased APC generation is associated with vascular atherosclerotic changes in Type 2 diabetic patients.

Authors+Show Affiliations

Department of Diabetes and Endocrinology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17971179

Citation

Matsumoto, K, et al. "Inverse Correlation Between Activated Protein C Generation and Carotid Atherosclerosis in Type 2 Diabetic Patients." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 24, no. 12, 2007, pp. 1322-8.
Matsumoto K, Yano Y, Gabazza EC, et al. Inverse correlation between activated protein C generation and carotid atherosclerosis in Type 2 diabetic patients. Diabet Med. 2007;24(12):1322-8.
Matsumoto, K., Yano, Y., Gabazza, E. C., Araki, R., Bruno, N. E., Suematsu, M., Akatsuka, H., Katsuki, A., Taguchi, O., Adachi, Y., & Sumida, Y. (2007). Inverse correlation between activated protein C generation and carotid atherosclerosis in Type 2 diabetic patients. Diabetic Medicine : a Journal of the British Diabetic Association, 24(12), 1322-8.
Matsumoto K, et al. Inverse Correlation Between Activated Protein C Generation and Carotid Atherosclerosis in Type 2 Diabetic Patients. Diabet Med. 2007;24(12):1322-8. PubMed PMID: 17971179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inverse correlation between activated protein C generation and carotid atherosclerosis in Type 2 diabetic patients. AU - Matsumoto,K, AU - Yano,Y, AU - Gabazza,E C, AU - Araki,R, AU - Bruno,N E, AU - Suematsu,M, AU - Akatsuka,H, AU - Katsuki,A, AU - Taguchi,O, AU - Adachi,Y, AU - Sumida,Y, Y1 - 2007/10/29/ PY - 2007/11/1/pubmed PY - 2008/4/17/medline PY - 2007/11/1/entrez SP - 1322 EP - 8 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 24 IS - 12 N2 - AIMS: Activated protein C (APC) is a key regulator of the clotting system and immune responses. We studied the relationship between the degree of atherosclerosis as measured by the intima-media thickness (IMT) of carotid artery and APC generation in Type 2 diabetic patients. METHODS: Eighty-seven Type 2 diabetic patients and 35 control subjects participated. APC generation was assessed by the plasma APC-protein C inhibitor complex (APC-PCI) levels and the mean IMT of carotid artery was measured by ultrasonography. The plasma levels of the thrombin-anti-thromobin complex (TAT) and platelet-derived growth factor (PDGF) were measured by enzyme-linked immunoassays. RESULTS: Plasma TAT levels were significantly higher in diabetic patients [2.03 (1.12, 2.56) ng/ml, median (25th, 75th percentile)] compared with control subjects [0.85 (0.55, 2.08) ng/ml, P < 0.01]. Plasma APC-PCI levels were significantly lower in diabetic patients [0.93 (0.74, 1.22) ng/ml], than in control subjects [1.66 (1.25, 2.36) ng/ml, P < 0.001]. The mean IMT was significantly increased in diabetic patients (0.881 +/- 0.242 mm; mean +/- sd) compared with control subjects (0.669 +/- 0.140 mm; P < 0.01). Univariate analysis showed a significant and inverse correlation between plasma APC-PCI levels and mean IMT (r = -0.32, P < 0.005), and multivariate regression analysis confirmed the independent correlation (P < 0.05). Moreover, plasma APC-PCI levels significantly and inversely correlated with plasma PDGF levels in diabetic patients (r = -0.30, P < 0.01). CONCLUSIONS: These results suggest that decreased APC generation is associated with vascular atherosclerotic changes in Type 2 diabetic patients. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/17971179/Inverse_correlation_between_activated_protein_C_generation_and_carotid_atherosclerosis_in_Type_2_diabetic_patients_ L2 - https://doi.org/10.1111/j.1464-5491.2007.02289.x DB - PRIME DP - Unbound Medicine ER -