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Prospective study of serum vitamin D and cancer mortality in the United States.
J Natl Cancer Inst. 2007 Nov 07; 99(21):1594-602.JNCI

Abstract

BACKGROUND

Vitamin D has been hypothesized to reduce cancer mortality through its effects on incidence and/or survival. Epidemiologic studies of the association of 25-hydroxyvitamin D [25(OH)D] and the risk of cancer, however, have been largely limited to incident cancers at a few sites.

METHODS

A total of 16,818 participants in the Third National Health and Nutrition Examination Survey who were 17 years or older at enrollment were followed from 1988-1994 through 2000. Levels of serum 25(OH)D were measured at baseline by radioimmunoassay. Cox proportional hazards regression models were used to examine the relationship between serum 25(OH)D levels and total cancer mortality (in the entire population or according to race/ethnicity, sex, age, and retinol status) and mortality from specific cancers. Because serum was collected in the south in cooler months and the north in warmer months, we examined associations by collection season. All statistical tests were two-sided.

RESULTS

We identified 536 cancer deaths in 146,578 person-years. Total cancer mortality was unrelated to baseline vitamin D status in the entire population, men, women, non-Hispanic whites, non-Hispanic blacks, Mexican Americans, and in persons younger than 70 or 70 years or older. We found no interaction between vitamin D and season or vitamin D and serum retinol. Colorectal cancer mortality was inversely related to serum 25(OH)D level, with levels 80 nmol/L or higher associated with a 72% risk reduction (95% confidence interval = 32% to 89%) compared with lower than 50 nmol/L, P(trend) = .02.

CONCLUSIONS

Our results do not support an association between 25(OH)D and total cancer mortality, although there was an inverse relationship between 25(OH)D levels and colorectal cancer mortality.

Authors+Show Affiliations

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Executive Plaza South Rm 7036, 6120 Executive Blvd, Bethesda, MD 20892-7238, USA. mf101e@nih.govNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

17971526

Citation

Freedman, D Michal, et al. "Prospective Study of Serum Vitamin D and Cancer Mortality in the United States." Journal of the National Cancer Institute, vol. 99, no. 21, 2007, pp. 1594-602.
Freedman DM, Looker AC, Chang SC, et al. Prospective study of serum vitamin D and cancer mortality in the United States. J Natl Cancer Inst. 2007;99(21):1594-602.
Freedman, D. M., Looker, A. C., Chang, S. C., & Graubard, B. I. (2007). Prospective study of serum vitamin D and cancer mortality in the United States. Journal of the National Cancer Institute, 99(21), 1594-602.
Freedman DM, et al. Prospective Study of Serum Vitamin D and Cancer Mortality in the United States. J Natl Cancer Inst. 2007 Nov 7;99(21):1594-602. PubMed PMID: 17971526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of serum vitamin D and cancer mortality in the United States. AU - Freedman,D Michal, AU - Looker,Anne C, AU - Chang,Shih-Chen, AU - Graubard,Barry I, Y1 - 2007/10/30/ PY - 2007/11/1/pubmed PY - 2007/11/14/medline PY - 2007/11/1/entrez SP - 1594 EP - 602 JF - Journal of the National Cancer Institute JO - J Natl Cancer Inst VL - 99 IS - 21 N2 - BACKGROUND: Vitamin D has been hypothesized to reduce cancer mortality through its effects on incidence and/or survival. Epidemiologic studies of the association of 25-hydroxyvitamin D [25(OH)D] and the risk of cancer, however, have been largely limited to incident cancers at a few sites. METHODS: A total of 16,818 participants in the Third National Health and Nutrition Examination Survey who were 17 years or older at enrollment were followed from 1988-1994 through 2000. Levels of serum 25(OH)D were measured at baseline by radioimmunoassay. Cox proportional hazards regression models were used to examine the relationship between serum 25(OH)D levels and total cancer mortality (in the entire population or according to race/ethnicity, sex, age, and retinol status) and mortality from specific cancers. Because serum was collected in the south in cooler months and the north in warmer months, we examined associations by collection season. All statistical tests were two-sided. RESULTS: We identified 536 cancer deaths in 146,578 person-years. Total cancer mortality was unrelated to baseline vitamin D status in the entire population, men, women, non-Hispanic whites, non-Hispanic blacks, Mexican Americans, and in persons younger than 70 or 70 years or older. We found no interaction between vitamin D and season or vitamin D and serum retinol. Colorectal cancer mortality was inversely related to serum 25(OH)D level, with levels 80 nmol/L or higher associated with a 72% risk reduction (95% confidence interval = 32% to 89%) compared with lower than 50 nmol/L, P(trend) = .02. CONCLUSIONS: Our results do not support an association between 25(OH)D and total cancer mortality, although there was an inverse relationship between 25(OH)D levels and colorectal cancer mortality. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/17971526/Prospective_study_of_serum_vitamin_D_and_cancer_mortality_in_the_United_States_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djm204 DB - PRIME DP - Unbound Medicine ER -