Citation
Kam, Michael K M., et al. "Prospective Randomized Study of Intensity-modulated Radiotherapy On Salivary Gland Function in Early-stage Nasopharyngeal Carcinoma Patients." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 25, no. 31, 2007, pp. 4873-9.
Kam MK, Leung SF, Zee B, et al. Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. J Clin Oncol. 2007;25(31):4873-9.
Kam, M. K., Leung, S. F., Zee, B., Chau, R. M., Suen, J. J., Mo, F., Lai, M., Ho, R., Cheung, K. Y., Yu, B. K., Chiu, S. K., Choi, P. H., Teo, P. M., Kwan, W. H., & Chan, A. T. (2007). Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 25(31), 4873-9.
Kam MK, et al. Prospective Randomized Study of Intensity-modulated Radiotherapy On Salivary Gland Function in Early-stage Nasopharyngeal Carcinoma Patients. J Clin Oncol. 2007 Nov 1;25(31):4873-9. PubMed PMID: 17971582.
TY - JOUR
T1 - Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients.
AU - Kam,Michael K M,
AU - Leung,Sing-Fai,
AU - Zee,Benny,
AU - Chau,Ricky M C,
AU - Suen,Joyce J S,
AU - Mo,Frankie,
AU - Lai,Maria,
AU - Ho,Rosalie,
AU - Cheung,Kin-yin,
AU - Yu,Brian K H,
AU - Chiu,Samuel K W,
AU - Choi,Peter H K,
AU - Teo,Peter M L,
AU - Kwan,Wing-hong,
AU - Chan,Anthony T C,
PY - 2007/11/1/pubmed
PY - 2007/12/6/medline
PY - 2007/11/1/entrez
SP - 4873
EP - 9
JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
JO - J Clin Oncol
VL - 25
IS - 31
N2 - PURPOSE: This randomized trial compared the rates of delayed xerostomia between two-dimensional radiation therapy (2DRT) and intensity-modulated radiation therapy (IMRT) in the treatment of early-stage nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS: Between November 2001 and December 2003, 60 patients with T1-2bN0-1M0 NPC were randomly assigned to receive either IMRT or 2DRT. Primary end point was incidence of observer-rated severe xerostomia at 1 year after treatment based on Radiotherapy Oncology Group /European Organisation for the Research and Treatment of Cancer late radiation morbidity scoring criteria. Parallel assessment with patient-reported outcome, stimulated parotid flow rate (SPFR), and stimulated whole saliva flow rate (SWSFR) were also made. RESULTS: At 1 year after treatment, patients in IMRT arm had lower incidence of observer-rated severe xerostomia than patients in the 2DRT arm (39.3% v 82.1%; P = .001), parallel with a higher fractional SPFR (0.90 v 0.05; P < .0001), and higher fractional SWSFR (0.41 v 0.20; P = .001). As for patient's subjective feeling, although a trend of improvement in patient-reported outcome was observed after IMRT, recovery was incomplete and there was no significant difference in patient-reported outcome between the two arms. CONCLUSION: IMRT is superior to 2DRT in preserving parotid function and results in less severe delayed xerostomia in the treatment of early-stage NPC. Incomplete improvement in patient's subjective xerostomia with parotid-sparing IMRT reflects the need to enhance protection of other salivary glands.
SN - 1527-7755
UR - https://www.unboundmedicine.com/medline/citation/17971582/Prospective_randomized_study_of_intensity_modulated_radiotherapy_on_salivary_gland_function_in_early_stage_nasopharyngeal_carcinoma_patients_
L2 - https://ascopubs.org/doi/10.1200/JCO.2007.11.5501?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed
DB - PRIME
DP - Unbound Medicine
ER -
