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[Study on RP-HPLC fingerprint of xinshao injection].
Zhongguo Zhong Yao Za Zhi. 2007 Aug; 32(15):1515-7.ZZ

Abstract

OBJECTIVE

To establish the fingerprint detecting standard of xinshao Injection by reversed phase high performance liquid chromatography.

METHOD

The chromatographic conditions were as follows: an Diamonsil C18 column was used, the mobile phase was composed of 80% acetontrile and 0.1% phosphoric acid with gradient elution, the flow rate 1.0 mL min(-1), column temperature was 40 degrees and the UV absorbance detection was set at 230 nm.

RESULT

A standard HPLC fingerprint procedure was developed for xinshao Injection, with 8 common peaks. Under the same selected chromatographic conditions, the HPLC fingerprints of raw drugs and their intermediate, finished products were obtained with good separation and correlation (no less than 0.97) according to the technical requirements of fingerprint on Injection of Chinese traditional medicine.

CONCLUSION

This method was accurate, repeatable and can be used as the important parameters of the quality control for xinshao injection.

Authors+Show Affiliations

Su H
School of Pharmacy, Guiyang Medical College, Guiyang 550004, China.
Wang AM
No affiliation info available
Wang YL
No affiliation info available
Lan YY
No affiliation info available
He X
No affiliation info available
Li YJ
No affiliation info available

MeSH

Chromatography, High Pressure LiquidDrug CombinationsDrugs, Chinese HerbalErigeronInjectionsPaeoniaPlants, MedicinalQuality ControlReproducibility of Results

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17972576

Citation

Su, Hong, et al. "[Study On RP-HPLC Fingerprint of Xinshao Injection]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 32, no. 15, 2007, pp. 1515-7.
Su H, Wang AM, Wang YL, et al. [Study on RP-HPLC fingerprint of xinshao injection]. Zhongguo Zhong Yao Za Zhi. 2007;32(15):1515-7.
Su, H., Wang, A. M., Wang, Y. L., Lan, Y. Y., He, X., & Li, Y. J. (2007). [Study on RP-HPLC fingerprint of xinshao injection]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 32(15), 1515-7.
Su H, et al. [Study On RP-HPLC Fingerprint of Xinshao Injection]. Zhongguo Zhong Yao Za Zhi. 2007;32(15):1515-7. PubMed PMID: 17972576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on RP-HPLC fingerprint of xinshao injection]. AU - Su,Hong, AU - Wang,Ai-min, AU - Wang,Yong-lin, AU - Lan,Yan-yu, AU - He,Xun, AU - Li,Yong-jun, PY - 2007/11/2/pubmed PY - 2008/1/10/medline PY - 2007/11/2/entrez SP - 1515 EP - 7 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 32 IS - 15 N2 - OBJECTIVE: To establish the fingerprint detecting standard of xinshao Injection by reversed phase high performance liquid chromatography. METHOD: The chromatographic conditions were as follows: an Diamonsil C18 column was used, the mobile phase was composed of 80% acetontrile and 0.1% phosphoric acid with gradient elution, the flow rate 1.0 mL min(-1), column temperature was 40 degrees and the UV absorbance detection was set at 230 nm. RESULT: A standard HPLC fingerprint procedure was developed for xinshao Injection, with 8 common peaks. Under the same selected chromatographic conditions, the HPLC fingerprints of raw drugs and their intermediate, finished products were obtained with good separation and correlation (no less than 0.97) according to the technical requirements of fingerprint on Injection of Chinese traditional medicine. CONCLUSION: This method was accurate, repeatable and can be used as the important parameters of the quality control for xinshao injection. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/17972576/[Study_on_RP_HPLC_fingerprint_of_xinshao_injection]_ DB - PRIME DP - Unbound Medicine ER -