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[Effects of kaixinsan on behavior and expression of p-CREB in hippocampus of chronic stress rats].
Zhongguo Zhong Yao Za Zhi. 2007 Aug; 32(15):1555-8.ZZ

Abstract

OBJECTIVE

To study the effects of kaixinsan on behavior and expression of p-CREB in hippocampus of the chronic stress rats.

METHOD

The male Wistar rats which gained the similar scores by Open-field test were selected, then the depression model rat was produced by separation and chronic unpredictable mild stress. Open-field test was performed to detect the behavior of rats and immunohistochemistry was used to observe the changes of p-CREB expression in hippocampus.

RESULT

On the 22nd day, the body weight and sacchar-intake of the depression model rats were all lower than those of the normal rats and the body weight and sacchar-intake of the rats treated by drugs were higher compared with model rats (P < 0.01). The depressive behavior in kaixinsan 4 g x kg(-1) group was significantly improved compared with the model group, the crossing scores and rearing scores were all increased (P < 0.01) and the expression of p-CREB in CA1, CA3 and DG in hippocampus was higher than that in the model group (P < 0.05 and P < 0.01).

CONCLUSION

Kaixinsan might improve depressive behavior by increasing expression of p-CREB in CA1, CA3 and DG in hippocampus of the chronic stress rats.

Authors+Show Affiliations

Dept. of Clinical Pharmacology, General Hospital of PLA, Beijing 100853, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17972588

Citation

Wang, Jin-liang, et al. "[Effects of Kaixinsan On Behavior and Expression of p-CREB in Hippocampus of Chronic Stress Rats]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 32, no. 15, 2007, pp. 1555-8.
Wang JL, Liu P, Tu HH, et al. [Effects of kaixinsan on behavior and expression of p-CREB in hippocampus of chronic stress rats]. Zhongguo Zhong Yao Za Zhi. 2007;32(15):1555-8.
Wang, J. L., Liu, P., Tu, H. H., Wang, Z. X., & Chen, G. Y. (2007). [Effects of kaixinsan on behavior and expression of p-CREB in hippocampus of chronic stress rats]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 32(15), 1555-8.
Wang JL, et al. [Effects of Kaixinsan On Behavior and Expression of p-CREB in Hippocampus of Chronic Stress Rats]. Zhongguo Zhong Yao Za Zhi. 2007;32(15):1555-8. PubMed PMID: 17972588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of kaixinsan on behavior and expression of p-CREB in hippocampus of chronic stress rats]. AU - Wang,Jin-liang, AU - Liu,Ping, AU - Tu,Hai-hua, AU - Wang,Zhong-xiao, AU - Chen,Gui-yun, PY - 2007/11/2/pubmed PY - 2008/1/10/medline PY - 2007/11/2/entrez SP - 1555 EP - 8 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 32 IS - 15 N2 - OBJECTIVE: To study the effects of kaixinsan on behavior and expression of p-CREB in hippocampus of the chronic stress rats. METHOD: The male Wistar rats which gained the similar scores by Open-field test were selected, then the depression model rat was produced by separation and chronic unpredictable mild stress. Open-field test was performed to detect the behavior of rats and immunohistochemistry was used to observe the changes of p-CREB expression in hippocampus. RESULT: On the 22nd day, the body weight and sacchar-intake of the depression model rats were all lower than those of the normal rats and the body weight and sacchar-intake of the rats treated by drugs were higher compared with model rats (P < 0.01). The depressive behavior in kaixinsan 4 g x kg(-1) group was significantly improved compared with the model group, the crossing scores and rearing scores were all increased (P < 0.01) and the expression of p-CREB in CA1, CA3 and DG in hippocampus was higher than that in the model group (P < 0.05 and P < 0.01). CONCLUSION: Kaixinsan might improve depressive behavior by increasing expression of p-CREB in CA1, CA3 and DG in hippocampus of the chronic stress rats. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/17972588/[Effects_of_kaixinsan_on_behavior_and_expression_of_p_CREB_in_hippocampus_of_chronic_stress_rats]_ L2 - https://medlineplus.gov/depression.html DB - PRIME DP - Unbound Medicine ER -