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Antioxidant and antimutagenic effects of the crude foliar extract and the alkaloid brachycerine of Psychotria brachyceras.
Environ Mol Mutagen. 2007 Dec; 48(9):728-34.EM

Abstract

The monoterpene indole alkaloid brachycerine from Psychotria brachyceras has been shown to be induced by UV and to have in vitro antioxidant activity, indicating a possible protective role against the secondary effects of this radiation. In this work, we have studied the antioxidant properties of brachycerine and a crude foliar extract from P. brachyceras by using Saccharomyces cerevisiae strains proficient and deficient in antioxidant defenses. The mutagenic and antimutagenic potential of these substances were assayed in S.cerevisiae N123 strain in the presence and absence of H2O2. In addition, we tested the antioxidant capacity of brachycerine and a crude foliar extract from P. brachyceras on hydroxyl radicals (OH) using the hypoxanthine/xanthine oxidase assay. The results show that brachycerine and the crude foliar extract of P. brachyceras have antioxidant and antimutagenic effects in yeast and probably this action is mainly due to the scavenging of OH radicals.

Authors+Show Affiliations

do Nascimento NC
Departamento de Botânica/Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Fragoso V
No affiliation info available
Moura DJ
No affiliation info available
e Silva AC
No affiliation info available
Fett-Neto AG
No affiliation info available
Saffi J
No affiliation info available

MeSH

Antimutagenic AgentsAntioxidantsCatalaseIndolesMonoterpenesPsychotriaSaccharomyces cerevisiaeSuperoxide Dismutase

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17973310

Citation

do Nascimento, Naíla Cannes, et al. "Antioxidant and Antimutagenic Effects of the Crude Foliar Extract and the Alkaloid Brachycerine of Psychotria Brachyceras." Environmental and Molecular Mutagenesis, vol. 48, no. 9, 2007, pp. 728-34.
do Nascimento NC, Fragoso V, Moura DJ, et al. Antioxidant and antimutagenic effects of the crude foliar extract and the alkaloid brachycerine of Psychotria brachyceras. Environ Mol Mutagen. 2007;48(9):728-34.
do Nascimento, N. C., Fragoso, V., Moura, D. J., e Silva, A. C., Fett-Neto, A. G., & Saffi, J. (2007). Antioxidant and antimutagenic effects of the crude foliar extract and the alkaloid brachycerine of Psychotria brachyceras. Environmental and Molecular Mutagenesis, 48(9), 728-34.
do Nascimento NC, et al. Antioxidant and Antimutagenic Effects of the Crude Foliar Extract and the Alkaloid Brachycerine of Psychotria Brachyceras. Environ Mol Mutagen. 2007;48(9):728-34. PubMed PMID: 17973310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and antimutagenic effects of the crude foliar extract and the alkaloid brachycerine of Psychotria brachyceras. AU - do Nascimento,Naíla Cannes, AU - Fragoso,Variluska, AU - Moura,Dinara Jaqueline, AU - e Silva,Ana Catarina Romano, AU - Fett-Neto,Arthur Germano, AU - Saffi,Jenifer, PY - 2007/11/2/pubmed PY - 2008/4/30/medline PY - 2007/11/2/entrez SP - 728 EP - 34 JF - Environmental and molecular mutagenesis JO - Environ Mol Mutagen VL - 48 IS - 9 N2 - The monoterpene indole alkaloid brachycerine from Psychotria brachyceras has been shown to be induced by UV and to have in vitro antioxidant activity, indicating a possible protective role against the secondary effects of this radiation. In this work, we have studied the antioxidant properties of brachycerine and a crude foliar extract from P. brachyceras by using Saccharomyces cerevisiae strains proficient and deficient in antioxidant defenses. The mutagenic and antimutagenic potential of these substances were assayed in S.cerevisiae N123 strain in the presence and absence of H2O2. In addition, we tested the antioxidant capacity of brachycerine and a crude foliar extract from P. brachyceras on hydroxyl radicals (OH) using the hypoxanthine/xanthine oxidase assay. The results show that brachycerine and the crude foliar extract of P. brachyceras have antioxidant and antimutagenic effects in yeast and probably this action is mainly due to the scavenging of OH radicals. SN - 0893-6692 UR - https://www.unboundmedicine.com/medline/citation/17973310/Antioxidant_and_antimutagenic_effects_of_the_crude_foliar_extract_and_the_alkaloid_brachycerine_of_Psychotria_brachyceras_ DB - PRIME DP - Unbound Medicine ER -