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Review article: the role of butyrate on colonic function.
Aliment Pharmacol Ther. 2008 Jan 15; 27(2):104-19.AP

Abstract

BACKGROUND

Butyrate, a short-chain fatty acid, is a main end-product of intestinal microbial fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis.

AIM

To provide an overview on the present knowledge of the bioactivity of butyrate, emphasizing effects and possible mechanisms of action in relation to human colonic function.

METHODS

A PubMed search was performed to select relevant publications using the search terms: 'butyrate, short-chain fatty acid, fibre, colon, inflammation, carcinogenesis, barrier, oxidative stress, permeability and satiety'.

RESULTS

Butyrate exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. In addition, butyrate may promote satiety. Two important mechanisms include the inhibition of nuclear factor kappa B activation and histone deacetylation. However, the observed effects of butyrate largely depend on concentrations and models used and human data are still limited.

CONCLUSION

Although most studies point towards beneficial effects of butyrate, more human in vivo studies are needed to contribute to our current understanding of butyrate-mediated effects on colonic function in health and disease.

Authors+Show Affiliations

TI Food and Nutrition, Wageningen, The Netherlands. h.hamer@intmed.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17973645

Citation

Hamer, H M., et al. "Review Article: the Role of Butyrate On Colonic Function." Alimentary Pharmacology & Therapeutics, vol. 27, no. 2, 2008, pp. 104-19.
Hamer HM, Jonkers D, Venema K, et al. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther. 2008;27(2):104-19.
Hamer, H. M., Jonkers, D., Venema, K., Vanhoutvin, S., Troost, F. J., & Brummer, R. J. (2008). Review article: the role of butyrate on colonic function. Alimentary Pharmacology & Therapeutics, 27(2), 104-19.
Hamer HM, et al. Review Article: the Role of Butyrate On Colonic Function. Aliment Pharmacol Ther. 2008 Jan 15;27(2):104-19. PubMed PMID: 17973645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review article: the role of butyrate on colonic function. AU - Hamer,H M, AU - Jonkers,D, AU - Venema,K, AU - Vanhoutvin,S, AU - Troost,F J, AU - Brummer,R-J, Y1 - 2007/10/25/ PY - 2007/11/2/pubmed PY - 2008/5/1/medline PY - 2007/11/2/entrez SP - 104 EP - 19 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 27 IS - 2 N2 - BACKGROUND: Butyrate, a short-chain fatty acid, is a main end-product of intestinal microbial fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis. AIM: To provide an overview on the present knowledge of the bioactivity of butyrate, emphasizing effects and possible mechanisms of action in relation to human colonic function. METHODS: A PubMed search was performed to select relevant publications using the search terms: 'butyrate, short-chain fatty acid, fibre, colon, inflammation, carcinogenesis, barrier, oxidative stress, permeability and satiety'. RESULTS: Butyrate exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. In addition, butyrate may promote satiety. Two important mechanisms include the inhibition of nuclear factor kappa B activation and histone deacetylation. However, the observed effects of butyrate largely depend on concentrations and models used and human data are still limited. CONCLUSION: Although most studies point towards beneficial effects of butyrate, more human in vivo studies are needed to contribute to our current understanding of butyrate-mediated effects on colonic function in health and disease. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/17973645/Review_article:_the_role_of_butyrate_on_colonic_function_ L2 - https://doi.org/10.1111/j.1365-2036.2007.03562.x DB - PRIME DP - Unbound Medicine ER -