Tags

Type your tag names separated by a space and hit enter

The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea.
Aliment Pharmacol Ther 2008; 27(2):173-85AP

Abstract

BACKGROUND

Prospective nationwide multicentre studies that have evaluated endoscopic findings and reflux symptoms using a well-designed questionnaire are very rare.

AIM

To compare the prevalence rates of and risk factors for erosive oesophagitis and non-erosive reflux disease (NERD) in the Korean population.

METHODS

A gastroscopic examination was performed on 25 536 subjects who visited 40 Healthcare Centers for a health check-up. A gastro-oesophageal reflux questionnaire and multivariate analysis were used to determine the risk factors for erosive oesophagitis and NERD.

RESULTS

2019 (8%) and 996 subjects (4%) had erosive oesophagitis and non-erosive reflux disease, respectively; only 58% of subjects with erosive oesophagitis had reflux symptoms. Multivariate analysis showed that the risk factors for erosive oesophagitis and NERD differed, i.e. those of erosive oesophagitis were male, a Helicobacter pylori eradication history, alcohol, body mass index > or =25 and hiatal hernia. In contrast, the risk factors for NERD were female, age <40 and > or =60 vs. 40-59 years, body mass index <23 and a monthly income <$1000, glucose > or =126 mg/dL, smoking, a stooping posture at work and antibiotic usage.

CONCLUSIONS

The prevalence rates of erosive oesophagitis and NERD were 8% and 4%, respectively, in Korean health check-up subjects. The risk factors for erosive oesophagitis and NERD were found to differ, which indicates that their underlying pathogeneses are distinct.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

17973646

Citation

Kim, N, et al. "The Prevalence of and Risk Factors for Erosive Oesophagitis and Non-erosive Reflux Disease: a Nationwide Multicentre Prospective Study in Korea." Alimentary Pharmacology & Therapeutics, vol. 27, no. 2, 2008, pp. 173-85.
Kim N, Lee SW, Cho SI, et al. The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea. Aliment Pharmacol Ther. 2008;27(2):173-85.
Kim, N., Lee, S. W., Cho, S. I., Park, C. G., Yang, C. H., Kim, H. S., ... Chung, I. S. (2008). The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea. Alimentary Pharmacology & Therapeutics, 27(2), pp. 173-85.
Kim N, et al. The Prevalence of and Risk Factors for Erosive Oesophagitis and Non-erosive Reflux Disease: a Nationwide Multicentre Prospective Study in Korea. Aliment Pharmacol Ther. 2008 Jan 15;27(2):173-85. PubMed PMID: 17973646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea. AU - Kim,N, AU - Lee,S W, AU - Cho,S I, AU - Park,C G, AU - Yang,C H, AU - Kim,H S, AU - Rew,J S, AU - Moon,J S, AU - Kim,S, AU - Park,S H, AU - Jung,H C, AU - Chung,I S, AU - ,, Y1 - 2007/10/25/ PY - 2007/11/2/pubmed PY - 2008/5/1/medline PY - 2007/11/2/entrez SP - 173 EP - 85 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 27 IS - 2 N2 - BACKGROUND: Prospective nationwide multicentre studies that have evaluated endoscopic findings and reflux symptoms using a well-designed questionnaire are very rare. AIM: To compare the prevalence rates of and risk factors for erosive oesophagitis and non-erosive reflux disease (NERD) in the Korean population. METHODS: A gastroscopic examination was performed on 25 536 subjects who visited 40 Healthcare Centers for a health check-up. A gastro-oesophageal reflux questionnaire and multivariate analysis were used to determine the risk factors for erosive oesophagitis and NERD. RESULTS: 2019 (8%) and 996 subjects (4%) had erosive oesophagitis and non-erosive reflux disease, respectively; only 58% of subjects with erosive oesophagitis had reflux symptoms. Multivariate analysis showed that the risk factors for erosive oesophagitis and NERD differed, i.e. those of erosive oesophagitis were male, a Helicobacter pylori eradication history, alcohol, body mass index > or =25 and hiatal hernia. In contrast, the risk factors for NERD were female, age <40 and > or =60 vs. 40-59 years, body mass index <23 and a monthly income <$1000, glucose > or =126 mg/dL, smoking, a stooping posture at work and antibiotic usage. CONCLUSIONS: The prevalence rates of erosive oesophagitis and NERD were 8% and 4%, respectively, in Korean health check-up subjects. The risk factors for erosive oesophagitis and NERD were found to differ, which indicates that their underlying pathogeneses are distinct. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/17973646/The_prevalence_of_and_risk_factors_for_erosive_oesophagitis_and_non_erosive_reflux_disease:_a_nationwide_multicentre_prospective_study_in_Korea_ L2 - https://doi.org/10.1111/j.1365-2036.2007.03561.x DB - PRIME DP - Unbound Medicine ER -