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Dopamine system genes associated with parenting in the context of daily hassles.
Genes Brain Behav. 2008 Jun; 7(4):403-10.GB

Abstract

The current study examined the molecular genetic foundations of sensitive parenting in humans and is the first to test the interaction between genes and environment in modulating parental sensitive responses to children. In a community sample of 176 Caucasian, middle class mothers with their 23-month-old toddlers at risk for externalizing behavior problems, the association between daily hassles and sensitive parenting was investigated. We tested whether two dopamine-related genes, dopamine D4 receptor (DRD4) and catechol-O-methyltransferase (COMT) gene polymorphisms, modulate parents' vulnerability to the negative influence of daily hassles on sensitive parenting behavior to their offspring. Sensitive parenting was observed in structured settings, and parents reported on their daily hassles through a standard questionnaire. In parents with the combination of genes leading to the least efficient dopaminergic system functioning (COMT val/val or val/met, DRD4-7Repeat), more daily hassles were associated with less sensitive parenting, and lower levels of daily hassles were associated with more sensitive parenting d = 1.12. The other combinations of COMT and DRD4 polymorphisms did not show significant associations between daily hassles and maternal sensitivity, suggesting differential susceptibility to hassles depending on parents' dopaminergic system genes. It is concluded that the study of (multiple) gene-environment interactions (in the current case: gene by gene by environment interaction, G x G x E) may explain why some parents are more and others less impacted by daily stresses in responding sensitively to their offspring's signals.

Authors+Show Affiliations

Centre for Child and Family Studies, Leiden University, The Netherlands. vanijzen@fsw.leidenuniv.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17973921

Citation

van IJzendoorn, M H., et al. "Dopamine System Genes Associated With Parenting in the Context of Daily Hassles." Genes, Brain, and Behavior, vol. 7, no. 4, 2008, pp. 403-10.
van IJzendoorn MH, Bakermans-Kranenburg MJ, Mesman J. Dopamine system genes associated with parenting in the context of daily hassles. Genes Brain Behav. 2008;7(4):403-10.
van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., & Mesman, J. (2008). Dopamine system genes associated with parenting in the context of daily hassles. Genes, Brain, and Behavior, 7(4), 403-10.
van IJzendoorn MH, Bakermans-Kranenburg MJ, Mesman J. Dopamine System Genes Associated With Parenting in the Context of Daily Hassles. Genes Brain Behav. 2008;7(4):403-10. PubMed PMID: 17973921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine system genes associated with parenting in the context of daily hassles. AU - van IJzendoorn,M H, AU - Bakermans-Kranenburg,M J, AU - Mesman,J, Y1 - 2007/10/31/ PY - 2007/11/2/pubmed PY - 2008/6/26/medline PY - 2007/11/2/entrez SP - 403 EP - 10 JF - Genes, brain, and behavior JO - Genes Brain Behav VL - 7 IS - 4 N2 - The current study examined the molecular genetic foundations of sensitive parenting in humans and is the first to test the interaction between genes and environment in modulating parental sensitive responses to children. In a community sample of 176 Caucasian, middle class mothers with their 23-month-old toddlers at risk for externalizing behavior problems, the association between daily hassles and sensitive parenting was investigated. We tested whether two dopamine-related genes, dopamine D4 receptor (DRD4) and catechol-O-methyltransferase (COMT) gene polymorphisms, modulate parents' vulnerability to the negative influence of daily hassles on sensitive parenting behavior to their offspring. Sensitive parenting was observed in structured settings, and parents reported on their daily hassles through a standard questionnaire. In parents with the combination of genes leading to the least efficient dopaminergic system functioning (COMT val/val or val/met, DRD4-7Repeat), more daily hassles were associated with less sensitive parenting, and lower levels of daily hassles were associated with more sensitive parenting d = 1.12. The other combinations of COMT and DRD4 polymorphisms did not show significant associations between daily hassles and maternal sensitivity, suggesting differential susceptibility to hassles depending on parents' dopaminergic system genes. It is concluded that the study of (multiple) gene-environment interactions (in the current case: gene by gene by environment interaction, G x G x E) may explain why some parents are more and others less impacted by daily stresses in responding sensitively to their offspring's signals. SN - 1601-183X UR - https://www.unboundmedicine.com/medline/citation/17973921/Dopamine_system_genes_associated_with_parenting_in_the_context_of_daily_hassles_ L2 - https://doi.org/10.1111/j.1601-183X.2007.00362.x DB - PRIME DP - Unbound Medicine ER -