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Prolonged intrauterine contraception: a seven-year randomized study of the levonorgestrel 20 mcg/day (LNg 20) and the Copper T380 Ag IUDS.
Contraception. 1991 Nov; 44(5):473-80.C

Abstract

A levonorgestrel-releasing IUD and the Copper T 380Ag IUD were in randomized comparison for seven years in five clinics. In two other clinics the randomized study was truncated at five years, but use of the Copper T continued. No pregnancies occurred to users of either device in years 6 and 7. Cumulative pregnancy rates were 1.1 per 100 at seven years for the steroid-releasing and 1.4 per 100 for the copper-releasing IUDs. Cumulative rates of PID did not differ between devices. Infection rates appeared to be lowest during the sixth and seventh years of the study. Termination attributable to amenorrhea was the principal contributor to differences in cumulative continuation rates between devices. At the five clinics that carried the comparative study to seven years, cumulative continuation rates were 24.9 per 100 for LNg20 IUD users and 29.4 per 100 for TCu 380Ag users. Women who used either method for periods of five to seven years experienced, on average, marked to mild increases in hemoglobin as compared with levels at admission. The Copper T380 family and the LNg20 IUDs represent the most effective reversible contraceptive methods yet studied in long-term randomized trials.

Authors+Show Affiliations

Center for Biomedical Research, Population Council, New York, NY 10021.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

1797462

Citation

Sivin, I, et al. "Prolonged Intrauterine Contraception: a Seven-year Randomized Study of the Levonorgestrel 20 Mcg/day (LNg 20) and the Copper T380 Ag IUDS." Contraception, vol. 44, no. 5, 1991, pp. 473-80.
Sivin I, Stern J, Coutinho E, et al. Prolonged intrauterine contraception: a seven-year randomized study of the levonorgestrel 20 mcg/day (LNg 20) and the Copper T380 Ag IUDS. Contraception. 1991;44(5):473-80.
Sivin, I., Stern, J., Coutinho, E., Mattos, C. E., el Mahgoub, S., Diaz, S., Pavez, M., Alvarez, F., Brache, V., & Thevenin, F. (1991). Prolonged intrauterine contraception: a seven-year randomized study of the levonorgestrel 20 mcg/day (LNg 20) and the Copper T380 Ag IUDS. Contraception, 44(5), 473-80.
Sivin I, et al. Prolonged Intrauterine Contraception: a Seven-year Randomized Study of the Levonorgestrel 20 Mcg/day (LNg 20) and the Copper T380 Ag IUDS. Contraception. 1991;44(5):473-80. PubMed PMID: 1797462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolonged intrauterine contraception: a seven-year randomized study of the levonorgestrel 20 mcg/day (LNg 20) and the Copper T380 Ag IUDS. A1 - Sivin,I, AU - Stern,J, AU - Coutinho,E, AU - Mattos,C E, AU - el Mahgoub,S, AU - Diaz,S, AU - Pavez,M, AU - Alvarez,F, AU - Brache,V, AU - Thevenin,F, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez KW - Adnexitis KW - Biology KW - Comparative Studies KW - Contraception KW - Contraception Continuation KW - Contraception Termination--statistics KW - Contraceptive Effectiveness KW - Contraceptive Methods KW - Contraceptive Usage KW - Demographic Factors KW - Diseases KW - Family Planning KW - Fertility KW - Fertility Measurements KW - Hemic System KW - Hemoglobin Level--statistics KW - Incidence KW - Infections KW - Iud KW - Iud, Copper Releasing KW - Iud, Hormone Releasing KW - Measurement KW - Method Acceptability KW - Pelvic Inflammatory Disease KW - Physiology KW - Population KW - Population Dynamics KW - Pregnancy Rate--statistics KW - Reproductive Tract Infections KW - Research Methodology KW - Studies SP - 473 EP - 80 JF - Contraception JO - Contraception VL - 44 IS - 5 N2 - A levonorgestrel-releasing IUD and the Copper T 380Ag IUD were in randomized comparison for seven years in five clinics. In two other clinics the randomized study was truncated at five years, but use of the Copper T continued. No pregnancies occurred to users of either device in years 6 and 7. Cumulative pregnancy rates were 1.1 per 100 at seven years for the steroid-releasing and 1.4 per 100 for the copper-releasing IUDs. Cumulative rates of PID did not differ between devices. Infection rates appeared to be lowest during the sixth and seventh years of the study. Termination attributable to amenorrhea was the principal contributor to differences in cumulative continuation rates between devices. At the five clinics that carried the comparative study to seven years, cumulative continuation rates were 24.9 per 100 for LNg20 IUD users and 29.4 per 100 for TCu 380Ag users. Women who used either method for periods of five to seven years experienced, on average, marked to mild increases in hemoglobin as compared with levels at admission. The Copper T380 family and the LNg20 IUDs represent the most effective reversible contraceptive methods yet studied in long-term randomized trials. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/1797462/Prolonged_intrauterine_contraception:_a_seven_year_randomized_study_of_the_levonorgestrel_20_mcg/day__LNg_20__and_the_Copper_T380_Ag_IUDS_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(91)90149-A DB - PRIME DP - Unbound Medicine ER -